Sclerosing effect of OC-108, a novel agent for hemorrhoids, is associated with granulomatous inflammation induced by aluminum

Journal of Pharmacological Sciences

Volumn 99, Issue 4, 2005, Pages 353-363

  Ono, Takashi ^a   Goto, Kazuko ^a   Takagi, Shiro ^a   Iwasaki, Shigeo ^a   Komatsu, Hirotsugu ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Aluminum; Fibrosis; Granuloma; OC 108; Tannic acid

Indexed keywords

ALUMINUM POTASSIUM SULFATE; OC 108; SCLEROSING AGENT; TANNIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; CELL INFILTRATION; DRUG EFFECT; DRUG MECHANISM; FIBROSIS; GRANULOMA; GRANULOMATOUS INFLAMMATION; HEMORRHOID; INFLAMMATION; INJECTION; INJECTION SITE; LEUKOCYTE; MALE; MOUSE; NECROSIS; NONHUMAN; RAT; SCLEROTHERAPY;

EID: 29144442360     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.FPJ05026X     Document Type: Article

References (15)

1. Goligher J. Haemorrhoids or piles. In: Surgery of the anus, rectum and colon. 5th ed. London: Bailliere Tindall; 1984. p. 98-149.
2. Santos G, Novell JR, Khoury G, Winslet MC, Lewis AA. Long-term results of large-dose, single-session phenol injection sclerotherapy for hemorrhoids. Dis Colon Rectum. 1993;36:958-961.
3. Shi Z, Zhou J, He X. On treatment of third degree internal hemorrhoids with "Xiaozhiling" injection. J Trad Chin Med. 1981;1:115-120.
4. Shi Z. Xiaozhiling four-step injection in treating hemorrhoids of stages III and IV - a sclerotherapeutic approach of thrombosing branches of artery rectalis superior. Chin J Trad W Med. 1997;3:246-249.
5. Takamura H, Takano M, Ohba H, Fukano M, Iwadare J, Koganezawa S, et al. Investigation of efficacy, safety and pharmacokinetics with OC-108, a novel agent for sclerosing therapy of internal hemorrhoids - early phase II study. Jpn Pharmacol Ther. 2004;32:355-365. (text in Japanese with English abstract)
6. Takano M, Iwadare J, Ohba H, Takamura H, Masuda Y, Matsuo K, et al. Sclerosing therapy of internal hemorrhoids with a novel sclerosing agent. Comparison with ligation and excision. Int J Colorectal Dis. 2006;21:44-51.
7. Takano M, Sakaue R, Fukushima Y, Kage M. Experimental study on the effect of sclerosing agents for hemorrhoids. J Jpn Soc Coloproctol. 1994;47:140-151. (text in Japanese with English abstract)
8. Selye H. Use of granuloma pouch technic in the study of antiphlogistic corticoids. Proc Soc Exp Biol Med. 1953;82:328-333.
9. Harada M, Takeuchi M, Fukao T, Katagiri K. A simple method for the quantitative extraction of dye extravasated into the skin. J Pharm Pharmacol. 1971;23:218-219.
10. 4 during experimental inflammation. Biochem Pharmacol. 1983;32:1353-1359.
11. Osol A. Astringents and antiperspirants. In: Osol A, editor. Remington's pharmaceutical sciences. 16th ed. Easton: Mack Publishing Co; 1980. p. 720-723.
12. Riches DWH. Macrophage involvement in wound repair, remodeling, and fibrosis. In: Clark RAF, editor. The molecular and cellular biology of wound repair. 2nd ed. New York: Plenum Press; 1996. p. 95-141.
13. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999;341:738-746.
14. Jackson JH, Cochrane CG. Leukocyte-induced tissue injury. Hematol/Oncol Clin North Am. 1988;2:317-334.
15. Haslam E, Lilley TH, Warminsky E, Liao H, Cai Y, Martin R, et al. Polyphenol complexation, a study in molecular recognition. In: Ho CT, Lee CY, Huang MT, editors. Phenolic compounds in food and their effects on health. I. Analysis, occurrence & chemistry. Washington DC: American Chemical Society; 1992. p. 8-50.