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Volumn 260-262, Issue , 2007, Pages 237-243

Hyperglycosylated HCG expression in pregnancy: Cellular origin and clinical applications

Author keywords

Cytotrophoblast; Early pregnancy loss; Hyperglycosylated hCG; Placenta

Indexed keywords

CHORIONIC GONADOTROPIN; HYPERGLYCOSYLATED CHORIONIC GONADOTROPIN; PLACENTAL PEPTIDE HORMONE; UNCLASSIFIED DRUG;

EID: 33751203568     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2006.02.021     Document Type: Review
Times cited : (24)

References (41)
  • 1
    • 0023835120 scopus 로고
    • Comparative study of the mucin-type sugar chains of human chorionic gonadotropin present in the urine of patients with trophoblastic diseases and healthy pregnant women
    • Amano J., Nishimura R., Mochizuki M., and Kobata A. Comparative study of the mucin-type sugar chains of human chorionic gonadotropin present in the urine of patients with trophoblastic diseases and healthy pregnant women. J. Biol. Chem. 263 (1988) 1157-1165
    • (1988) J. Biol. Chem. , vol.263 , pp. 1157-1165
    • Amano, J.1    Nishimura, R.2    Mochizuki, M.3    Kobata, A.4
  • 3
    • 0033672037 scopus 로고    scopus 로고
    • Comparison of urinary hyperglycosylated human chorionic gonadotropin concentration with the serum triple screen for Down syndrome detection in high-risk pregnancies
    • Bahado-Singh R.O., Oz U., Shahabi S., Mahoney M.J., Baumgarten A., and Cole L.A. Comparison of urinary hyperglycosylated human chorionic gonadotropin concentration with the serum triple screen for Down syndrome detection in high-risk pregnancies. Am. J. Obstet. Gynecol. 183 (2000) 1114-1118
    • (2000) Am. J. Obstet. Gynecol. , vol.183 , pp. 1114-1118
    • Bahado-Singh, R.O.1    Oz, U.2    Shahabi, S.3    Mahoney, M.J.4    Baumgarten, A.5    Cole, L.A.6
  • 4
    • 22844437900 scopus 로고    scopus 로고
    • Specific measurement of O-linked core 2 sugar-containing isoforms of hyperglycosylated human chorionic gonadotropin by antibody B152
    • Birken S. Specific measurement of O-linked core 2 sugar-containing isoforms of hyperglycosylated human chorionic gonadotropin by antibody B152. Tumour Biol. 26 (2005) 131-141
    • (2005) Tumour Biol. , vol.26 , pp. 131-141
    • Birken, S.1
  • 5
    • 0032985193 scopus 로고    scopus 로고
    • Development and characterization of antibodies to a nicked and hyperglycosylated form of hCG from a choriocarcinoma patient: generation of antibodies that differentiate between pregnancy hCG and choriocarcinoma hCG
    • Birken S., Krichevsky A., O'Connor J., Schlatterer J., Cole L., Kardana A., and Canfield R. Development and characterization of antibodies to a nicked and hyperglycosylated form of hCG from a choriocarcinoma patient: generation of antibodies that differentiate between pregnancy hCG and choriocarcinoma hCG. Endocrine 10 (1999) 137-144
    • (1999) Endocrine , vol.10 , pp. 137-144
    • Birken, S.1    Krichevsky, A.2    O'Connor, J.3    Schlatterer, J.4    Cole, L.5    Kardana, A.6    Canfield, R.7
  • 7
    • 0035200889 scopus 로고    scopus 로고
    • Detection of early pregnancy forms of human chorionic gonadotropin by home pregnancy test devices
    • Butler S.A., Khanlian S.A., and Cole L.A. Detection of early pregnancy forms of human chorionic gonadotropin by home pregnancy test devices. Clin. Chem. 47 (2001) 2131-2136
    • (2001) Clin. Chem. , vol.47 , pp. 2131-2136
    • Butler, S.A.1    Khanlian, S.A.2    Cole, L.A.3
  • 9
    • 0023619442 scopus 로고
    • The O-linked oligosaccharide structures are striking different on pregnancy and choriocarcinoma HCG
    • Cole L.A. The O-linked oligosaccharide structures are striking different on pregnancy and choriocarcinoma HCG. J. Clin. Endocrinol. Metab. 65 (1987) 811-813
    • (1987) J. Clin. Endocrinol. Metab. , vol.65 , pp. 811-813
    • Cole, L.A.1
  • 11
    • 0242635988 scopus 로고    scopus 로고
    • Hyperglycosylated hCG (invasive trophoblast antigen, ITA) a key antigen for early pregnancy detection
    • Cole L.A., Khanlian S.A., Sutton J.M., Davies S., and Stephens N.D. Hyperglycosylated hCG (invasive trophoblast antigen, ITA) a key antigen for early pregnancy detection. Clin. Biochem. 36 (2003) 647-655
    • (2003) Clin. Biochem. , vol.36 , pp. 647-655
    • Cole, L.A.1    Khanlian, S.A.2    Sutton, J.M.3    Davies, S.4    Stephens, N.D.5
  • 12
    • 0031786632 scopus 로고    scopus 로고
    • Hyperglycosylated hCG, a potential alternative to hCG in Down syndrome screening
    • Cole L.A., Omrani A., Cermik D., Bahado-Singh R.O., and Mahoney M.J. Hyperglycosylated hCG, a potential alternative to hCG in Down syndrome screening. Prenat. Diagn. 18 (1998) 926-933
    • (1998) Prenat. Diagn. , vol.18 , pp. 926-933
    • Cole, L.A.1    Omrani, A.2    Cermik, D.3    Bahado-Singh, R.O.4    Mahoney, M.J.5
  • 13
    • 0032736474 scopus 로고    scopus 로고
    • Hyperglycosylated human chorionic gonadotropin (invasive trophoblast antigen) immunoassay: a new basis for gestational Down syndrome screening
    • Cole L.A., Shahabi S., Oz U.A., Bahado-Singh R.O., and Mahoney M.J. Hyperglycosylated human chorionic gonadotropin (invasive trophoblast antigen) immunoassay: a new basis for gestational Down syndrome screening. Clin. Chem. 45 (1999) 2109-2119
    • (1999) Clin. Chem. , vol.45 , pp. 2109-2119
    • Cole, L.A.1    Shahabi, S.2    Oz, U.A.3    Bahado-Singh, R.O.4    Mahoney, M.J.5
  • 15
    • 0032831157 scopus 로고    scopus 로고
    • Maternal urine hyperglycosylated hCG in pregnancies with Down syndrome
    • Cuckle H.S., Shahabi S., Sehmi I.K., Jones R., and Cole L.A. Maternal urine hyperglycosylated hCG in pregnancies with Down syndrome. Prenat. Diagn. 19 (1999) 918-920
    • (1999) Prenat. Diagn. , vol.19 , pp. 918-920
    • Cuckle, H.S.1    Shahabi, S.2    Sehmi, I.K.3    Jones, R.4    Cole, L.A.5
  • 16
    • 0030224260 scopus 로고    scopus 로고
    • More in vitro bioactive, shorter-lived human chorionic gonadotrophin charge isoforms increase at the end of the first and during the third trimesters of gestation
    • Diaz-Cueto L., Barrios-de-Tomasi J., Timossi C., Mendez J.P., and Ulloa-Aguirre A. More in vitro bioactive, shorter-lived human chorionic gonadotrophin charge isoforms increase at the end of the first and during the third trimesters of gestation. Mol. Hum. Reprod. 2 (1996) 643-650
    • (1996) Mol. Hum. Reprod. , vol.2 , pp. 643-650
    • Diaz-Cueto, L.1    Barrios-de-Tomasi, J.2    Timossi, C.3    Mendez, J.P.4    Ulloa-Aguirre, A.5
  • 17
    • 14844335722 scopus 로고    scopus 로고
    • First-trimester screening: an overview
    • Eiben B., and Glaubitz R. First-trimester screening: an overview. J. Histochem. Cytochem. 53 (2005) 281-283
    • (2005) J. Histochem. Cytochem. , vol.53 , pp. 281-283
    • Eiben, B.1    Glaubitz, R.2
  • 18
    • 0031196046 scopus 로고    scopus 로고
    • Carbohydrate and peptide structure of the alpha and beta subunits of chorionic gonadotropin (hCG): characteristics and variants in 32 subunit preparations from normal and aberrant pregnancy and choriocarcinoma
    • Elliott M.M., Kardana A., Lustbader J.W., and Cole L.A. Carbohydrate and peptide structure of the alpha and beta subunits of chorionic gonadotropin (hCG): characteristics and variants in 32 subunit preparations from normal and aberrant pregnancy and choriocarcinoma. Endocrine 7 (1997) 15-32
    • (1997) Endocrine , vol.7 , pp. 15-32
    • Elliott, M.M.1    Kardana, A.2    Lustbader, J.W.3    Cole, L.A.4
  • 22
    • 0032834630 scopus 로고    scopus 로고
    • Structure, pathology and function of the N-linked sugar chains of human chorionic gonadotropin
    • Kobata A., and Takeuchi M. Structure, pathology and function of the N-linked sugar chains of human chorionic gonadotropin. Biochim. Biophys. Acta 1455 (1999) 315-326
    • (1999) Biochim. Biophys. Acta , vol.1455 , pp. 315-326
    • Kobata, A.1    Takeuchi, M.2
  • 23
    • 0032935044 scopus 로고    scopus 로고
    • Early pregnancy human chorionic gonadotropin (hCG) isoforms measured by an immunometric assay for choriocarcinoma-like hCG
    • Kovalevskaya G., Birken S., Kakuma T., and O'Connor J.F. Early pregnancy human chorionic gonadotropin (hCG) isoforms measured by an immunometric assay for choriocarcinoma-like hCG. J. Endocrinol. 161 (1999) 99-106
    • (1999) J. Endocrinol. , vol.161 , pp. 99-106
    • Kovalevskaya, G.1    Birken, S.2    Kakuma, T.3    O'Connor, J.F.4
  • 24
    • 18344364663 scopus 로고    scopus 로고
    • Differential expression of hCG glycosylation isoforms in failing and continuing pregnancies: preliminary characterization of the hyperglycosylated hCG epitope
    • Kovalevskaya G., Birken S., Kakuma T., Ozaki N., Sauer M., Lindheim S., Cohen M., Kelly A., Schlatterer J., and O'Connor J.F. Differential expression of hCG glycosylation isoforms in failing and continuing pregnancies: preliminary characterization of the hyperglycosylated hCG epitope. J. Endocrinol. 172 (2002) 497-506
    • (2002) J. Endocrinol. , vol.172 , pp. 497-506
    • Kovalevskaya, G.1    Birken, S.2    Kakuma, T.3    Ozaki, N.4    Sauer, M.5    Lindheim, S.6    Cohen, M.7    Kelly, A.8    Schlatterer, J.9    O'Connor, J.F.10
  • 25
    • 0037200677 scopus 로고    scopus 로고
    • Trophoblast origin of hCG isoforms: cytotrophoblasts are the primary source of choriocarcinoma-like hCG
    • Kovalevskaya G., Genbacev O., Fisher S.J., Caceres E., and O'Connor J.F. Trophoblast origin of hCG isoforms: cytotrophoblasts are the primary source of choriocarcinoma-like hCG. Mol. Cell. Endocrinol. 194 (2002) 147-155
    • (2002) Mol. Cell. Endocrinol. , vol.194 , pp. 147-155
    • Kovalevskaya, G.1    Genbacev, O.2    Fisher, S.J.3    Caceres, E.4    O'Connor, J.F.5
  • 26
    • 0020333131 scopus 로고
    • Random-effects models for longitudinal data
    • Laird N.M., and Ware J.H. Random-effects models for longitudinal data. Biometrics 38 (1982) 963-974
    • (1982) Biometrics , vol.38 , pp. 963-974
    • Laird, N.M.1    Ware, J.H.2
  • 28
    • 0032524307 scopus 로고    scopus 로고
    • Developmental changes in the glycosylation of glycoprotein hormone free alpha subunit during pregnancy
    • Nemansky M., Thotakura N.R., Lyons C.D., Ye S., Reinhold B.B., Reinhold V.N., and Blithe D.L. Developmental changes in the glycosylation of glycoprotein hormone free alpha subunit during pregnancy. J. Biol. Chem. 273 (1998) 12068-12076
    • (1998) J. Biol. Chem. , vol.273 , pp. 12068-12076
    • Nemansky, M.1    Thotakura, N.R.2    Lyons, C.D.3    Ye, S.4    Reinhold, B.B.5    Reinhold, V.N.6    Blithe, D.L.7
  • 29
    • 15944409220 scopus 로고    scopus 로고
    • Multicenter study of first-trimester screening for trisomy 21 in 75,821 pregnancies: results and estimation of the potential impact of individual risk-orientated two-stage first-trimester screening
    • Nicolaides K.H., Spencer K., Avgidou K., Faiola S., and Falcon O. Multicenter study of first-trimester screening for trisomy 21 in 75,821 pregnancies: results and estimation of the potential impact of individual risk-orientated two-stage first-trimester screening. Ultrasound Obstet. Gynecol. 25 (2005) 221-226
    • (2005) Ultrasound Obstet. Gynecol. , vol.25 , pp. 221-226
    • Nicolaides, K.H.1    Spencer, K.2    Avgidou, K.3    Faiola, S.4    Falcon, O.5
  • 30
    • 0023691010 scopus 로고
    • Fragmentation of the beta-subunit of human chorionic gonadotropin produced by choriocarcinoma
    • Nishimura R., Ide K., Utsunomiya T., Kitajima T., Yuki Y., and Mochizuki M. Fragmentation of the beta-subunit of human chorionic gonadotropin produced by choriocarcinoma. Endocrinology 123 (1988) 420-425
    • (1988) Endocrinology , vol.123 , pp. 420-425
    • Nishimura, R.1    Ide, K.2    Utsunomiya, T.3    Kitajima, T.4    Yuki, Y.5    Mochizuki, M.6
  • 31
    • 0032436377 scopus 로고    scopus 로고
    • Differential urinary gonadotropin profiles in early pregnancy and early pregnancy loss
    • O'Connor J.F., Ellish N., Kakuma T., Schlatterer J., and Kovalevskaya G. Differential urinary gonadotropin profiles in early pregnancy and early pregnancy loss. Prenat. Diagn. 18 (1998) 1232-1240
    • (1998) Prenat. Diagn. , vol.18 , pp. 1232-1240
    • O'Connor, J.F.1    Ellish, N.2    Kakuma, T.3    Schlatterer, J.4    Kovalevskaya, G.5
  • 32
    • 0028152865 scopus 로고
    • Recent advances in the chemistry and immunochemistry of human chorionic gonadotropin: impact on clinical measurements
    • (Review; 207 refs.)
    • O'Connor J.F., Birken S., Lustbader J.W., Krichevsky A., Chen Y., and Canfield R.E. Recent advances in the chemistry and immunochemistry of human chorionic gonadotropin: impact on clinical measurements. Endocr. Rev. 15 (1994) 650-683 (Review; 207 refs.)
    • (1994) Endocr. Rev. , vol.15 , pp. 650-683
    • O'Connor, J.F.1    Birken, S.2    Lustbader, J.W.3    Krichevsky, A.4    Chen, Y.5    Canfield, R.E.6
  • 33
    • 23044502929 scopus 로고    scopus 로고
    • Maternal serum invasive trophoblast antigen and first-trimester Down syndrome screening
    • Palomaki G.E., Knight G.J., Neveux L.M., Pandian R., and Haddow J.E. Maternal serum invasive trophoblast antigen and first-trimester Down syndrome screening. Clin. Chem. 51 (2005) 1499-1504
    • (2005) Clin. Chem. , vol.51 , pp. 1499-1504
    • Palomaki, G.E.1    Knight, G.J.2    Neveux, L.M.3    Pandian, R.4    Haddow, J.E.5
  • 34
    • 4644280427 scopus 로고    scopus 로고
    • Maternal serum invasive trophoblast antigen (hyperglycosylated hCG) as a screening marker for Down syndrome during the second trimester
    • Palomaki G.E., Neveux L.M., Knight G.J., Haddow J.E., and Pandian R. Maternal serum invasive trophoblast antigen (hyperglycosylated hCG) as a screening marker for Down syndrome during the second trimester. Clin. Chem. 50 (2004) 1804-1808
    • (2004) Clin. Chem. , vol.50 , pp. 1804-1808
    • Palomaki, G.E.1    Neveux, L.M.2    Knight, G.J.3    Haddow, J.E.4    Pandian, R.5
  • 35
    • 3242763029 scopus 로고    scopus 로고
    • Second-trimester maternal serum invasive trophoblast antigen: a marker for Down syndrome screening
    • Pandian R., Cole L.A., and Palomaki G.E. Second-trimester maternal serum invasive trophoblast antigen: a marker for Down syndrome screening. Clin. Chem. 50 (2004) 1433-1435
    • (2004) Clin. Chem. , vol.50 , pp. 1433-1435
    • Pandian, R.1    Cole, L.A.2    Palomaki, G.E.3
  • 36
    • 0026748729 scopus 로고
    • Glycosylation changes in human chorionic gonadotropin and free alpha subunit as gestation progresses
    • Skarulis M.C., Wehmann R.E., Nisula B.C., and Blithe D.L. Glycosylation changes in human chorionic gonadotropin and free alpha subunit as gestation progresses. J. Clin. Endocrinol. Metab. 75 (1992) 91-96
    • (1992) J. Clin. Endocrinol. Metab. , vol.75 , pp. 91-96
    • Skarulis, M.C.1    Wehmann, R.E.2    Nisula, B.C.3    Blithe, D.L.4
  • 37
    • 0034108953 scopus 로고    scopus 로고
    • Is maternal serum total hCG a marker of trisomy 21 in the first trimester of pregnancy?
    • Spencer K., Berry E., Crossley J.A., Aitken D.A., and Nicolaides K.H. Is maternal serum total hCG a marker of trisomy 21 in the first trimester of pregnancy?. Prenat. Diagn. 20 (2000) 311-317
    • (2000) Prenat. Diagn. , vol.20 , pp. 311-317
    • Spencer, K.1    Berry, E.2    Crossley, J.A.3    Aitken, D.A.4    Nicolaides, K.H.5
  • 38
    • 0034536224 scopus 로고    scopus 로고
    • Urinary hyperglycosylated hCG in first trimester screening for chromosomal abnormalities
    • Weinans M.J., Butler S.A., Mantingh A., and Cole L.A. Urinary hyperglycosylated hCG in first trimester screening for chromosomal abnormalities. Prenat. Diagn. 20 (2000) 976-978
    • (2000) Prenat. Diagn. , vol.20 , pp. 976-978
    • Weinans, M.J.1    Butler, S.A.2    Mantingh, A.3    Cole, L.A.4
  • 39
    • 23444441482 scopus 로고    scopus 로고
    • Invasive trophoblast antigen (hyperglycosylated human chorionic gonadotropin) as a first-trimester serum marker for Down syndrome
    • Weinans M.J., Sancken U., Pandian R., van de Ouweland J.M., de Bruijn H.W., Holm J.P., and Mantingh A. Invasive trophoblast antigen (hyperglycosylated human chorionic gonadotropin) as a first-trimester serum marker for Down syndrome. Clin. Chem. 51 (2005) 1276-1279
    • (2005) Clin. Chem. , vol.51 , pp. 1276-1279
    • Weinans, M.J.1    Sancken, U.2    Pandian, R.3    van de Ouweland, J.M.4    de Bruijn, H.W.5    Holm, J.P.6    Mantingh, A.7
  • 40
    • 0023627501 scopus 로고
    • Some qualitative differences of hCG in serum from early and late pregnancies and trophoblastic diseases
    • Wide L., and Hobson B. Some qualitative differences of hCG in serum from early and late pregnancies and trophoblastic diseases. Acta Endocrinol. (Copenh.) 116 (1987) 465-472
    • (1987) Acta Endocrinol. (Copenh.) , vol.116 , pp. 465-472
    • Wide, L.1    Hobson, B.2
  • 41
    • 0028302016 scopus 로고
    • A change in the isoforms of human chorionic gonadotropin occurs around the 13th week of gestation
    • Wide L., Lee J.Y., and Rasmussen C. A change in the isoforms of human chorionic gonadotropin occurs around the 13th week of gestation. J. Clin. Endocrinol. Metab. 78 (1994) 1419-1423
    • (1994) J. Clin. Endocrinol. Metab. , vol.78 , pp. 1419-1423
    • Wide, L.1    Lee, J.Y.2    Rasmussen, C.3


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