Gatifloxacin acutely stimulates insulin secretion and chronically suppresses insulin biosynthesis

European Journal of Pharmacology

Volumn 553, Issue 1-3, 2006, Pages 67-72

  Yamada, Chizumi ^a   Nagashima, Kazuaki ^a   Takahashi, Akira ^a   Ueno, Hiroyuki ^a   Kawasaki, Yukiko ^a   Yamada, Yuichiro ^a   Seino, Yutaka ^a,b   Inagaki, Nobuya ^a,c  

^a KYOTO UNIVERSITY   (Japan)

^b KANSAI DENRYOKU HOSPITAL   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Gatifloxacin; Hyperglycemia; Hypoglycemia; Insulin secretion; Islet insulin content; KATP (ATP sensitive K+) channel

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM); FLEROXACIN; GATIFLOXACIN; GLIBENCLAMIDE; GLUCOSE; INSULIN; LEVOFLOXACIN; NORFLOXACIN; OFLOXACIN; SULFONYLUREA;

ACUTE DRUG ADMINISTRATION; ANIMAL CELL; ARTICLE; BLOOD GLUCOSE MONITORING; CHRONIC DRUG ADMINISTRATION; CLINICAL PRACTICE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MONITORING; DRUG WITHDRAWAL; GERIATRIC PATIENT; HORMONAL REGULATION; HORMONE INHIBITION; HYPERGLYCEMIA; HYPOGLYCEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN SYNTHESIS; KIDNEY FAILURE; MALE; METABOLIC DISORDER; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; ANTI-INFECTIVE AGENTS; BLOOD GLUCOSE; CELL LINE, TUMOR; CELL SEPARATION; FLUOROQUINOLONES; GLYBURIDE; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN ANTAGONISTS; INSULINOMA; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; PANCREATIC NEOPLASMS; QUINOLONES; RNA, MESSENGER;

EID: 33751189813     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.09.043     Document Type: Article

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