Sodium Current and Arrhythmogenesis in Heart Failure

Heart Failure Clinics

Volumn 1, Issue 2, 2005, Pages 193-205

  Santana, Luis F ^a   Núñez Durán, Harol ^b   Dilly, Keith W ^a   Lederer, W Jonathan ^c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

^c UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIARRHYTHMIC AGENT; CALCIUM; LIDOCAINE; SODIUM; SODIUM CHANNEL BLOCKING AGENT; TETRODOTOXIN;

ACUTE HEART INFARCTION; ARRHYTHMOGENESIS; CALCIUM TRANSPORT; EXCITATION CONTRACTION COUPLING; HEART ARRHYTHMIA; HEART DEPOLARIZATION; HEART FAILURE; HEART MUSCLE POTENTIAL; HEART VENTRICLE; HUMAN; LONG QT SYNDROME; MUSCLE CELL; NONHUMAN; QT INTERVAL; QT PROLONGATION; REVIEW; SARCOPLASMIC RETICULUM; SODIUM CURRENT;

ACTION POTENTIALS; ANIMALS; ARRHYTHMIA; CALCIUM; HEART FAILURE, CONGESTIVE; HUMANS; LONG QT SYNDROME; MYOCYTES, CARDIAC; SARCOPLASMIC RETICULUM; SODIUM CHANNELS;

EID: 33751159419     PISSN: 15517136     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hfc.2005.06.003     Document Type: Review

References (52)

1. Virmani R., Burke A.P., and Farb A. Sudden cardiac death. Cardiovasc Pathol 10 (2001) 275-282
2. Moss A.J., Schwartz P.J., Crampton R.S., et al. The long QT syndrome: prospective longitudinal study of 328 families. Circulation 84 (1991) 1136-1144
3. Kannel W.B., Plehn J.F., and Cupples L.A. Cardiac failure and sudden death in the Framingham Study. Am Heart J 115 (1988) 869-875
4. Pinto J.M., and Boyden P.A. Electrical remodeling in ischemia and infarction. Cardiovasc Res 42 (1999) 284-297
5. + currents in myocytes from epicardial border zone of the infarcted heart: a possible ionic mechanism for reduced excitability and postrepolarization refractoriness. Circ Res 81 (1997) 110-119
6. Abriel H., Wehrens X.H., Benhorin J., et al. Molecular pharmacology of the sodium channel mutation D1790G linked to the long-QT syndrome. Circulation 102 (2000) 921-925
7. Wehrens X.H., Abriel H., Cabo C., et al. Arrhythmogenic mechanism of an LQT-3 mutation of the human heart Na(+) channel alpha-subunit: a computational analysis. Circulation 102 (2000) 584-590
8. Knollmann B.C., Knollmann-Ritschel B.E., Weissman N.J., et al. Remodelling of ionic currents in hypertrophied and failing hearts of transgenic mice overexpressing calsequestrin. J Physiol 525 Pt 2 (2000) 483-498
9. Ufret-Vincenty C.A., Baro D.J., Lederer W.J., et al. Role of sodium channel deglycosylation in the genesis of cardiac arrhythmias in heart failure. J Biol Chem 276 (2001) 28197-28203
10. Barrans J.D., Allen P.D., Stamatiou D., et al. Global gene expression profiling of end-stage dilated cardiomyopathy using a human cardiovascular-based cDNA microarray. Am J Pathol 160 (2002) 2035-2043
11. Dempsey A.A., Dzau V.J., and Liew C.C. Cardiovascular genomics: estimating the total number of genes expressed in the human cardiovascular system. J Mol Cell Cardiol 33 (2001) 1879-1886
12. Hille B. Ionic channels of excitable membranes (2001), Sinauer Associates, Suderland (MA)
13. Koumi S., Backer C.L., and Arentzen C.E. Characterization of inwardly rectifying K + channel in human cardiac myocytes: alterations in channel behavior in myocytes isolated from patients with idiopathic dilated cardiomyopathy. Circulation 92 (1995) 164-174
14. Nuss H.B., Kaab S., Kass D.A., et al. Cellular basis of ventricular arrhythmias and abnormal automaticity in heart failure. Am J Physiol 277 (1999) H80-H91
15. Rossow C.F., Minami E., Chase E.G., et al. NFATc3-induced reductions in voltage-gated K + currents after myocardial infarction. Circ Res 94 (2004) 1340-1350
16. Thuringer D., Deroubaix E., Coulombe A., et al. Ionic basis of the action potential prolongation in ventricular myocytes from Syrian hamsters with dilated cardiomyopathy. Cardiovasc Res 31 (1996) 747-757
17. Kass R.S., Tsien R.W., and Weingart R. Ionic basis of transient inward current induced by strophanthidin in cardiac Purkinje fibres. J Physiol 281 (1978) 209-226
18. Lederer W.J., and Tsien R.W. Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibres. J Physiol 263 (1976) 73-100
19. Pogwizd S.M., Schlotthauer K., Li L., et al. Arrhythmogenesis and contractile dysfunction in heart failure: roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness. Circ Res 88 (2001) 1159-1167
20. Pinto J.M., and Boyden P.A. Reduced inward rectifying and increased E-4031-sensitive K + current density in arrhythmogenic subendocardial Purkinje myocytes from the infarcted heart. J Cardiovasc Electrophysiol 9 (1998) 299-311
21. Ruskin J.N. The cardiac arrhythmia suppression trial (CAST). N Engl J Med 321 (1989) 386-388
22. Bennett P.B., Yazawa K., Makita N., et al. Molecular mechanism for an inherited cardiac arrhythmia. Nature 376 (1995) 683-685
23. Wang D.W., Yazawa K., George Jr. A.L., et al. Characterization of human cardiac Na+ channel mutations in the congenital long QT syndrome. Proc Natl Acad Sci U S A 93 (1996) 13200-13205
24. Luo C.H., and Rudy Y. A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circ Res 74 (1994) 1097-1113
25. Trafford A.W., Diaz M.E., and Eisner D.A. Coordinated control of cell Ca(2 +) loading and triggered release from the sarcoplasmic reticulum underlies the rapid inotropic response to increased L-type Ca(2 +) current. Circ Res 88 (2001) 195-201
26. Kass R.S., Lederer W.J., Tsien R.W., et al. Role of calcium ions in transient inward currents and aftercontractions induced by strophanthidin in cardiac Purkinje fibres. J Physiol 281 (1978) 187-208
27. Nuss H.B., and Marban E. Electrophysiological properties of neonatal mouse cardiac myocytes in primary culture. J Physiol 479 (1994) 265-279
28. Arber S., Hunter J.J., Ross Jr. J., et al. MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure. Cell 88 (1997) 393-403
29. Esposito G., Santana L.F., Dilly K., et al. Cellular and functional defects in a mouse model of heart failure. Am J Physiol Heart Circ Physiol 279 (2000) H3101-H3112
30. Zolk O., Caroni P., and Bohm M. Decreased expression of the cardiac LIM domain protein MLP in chronic human heart failure. Circulation 101 (2000) 2674-2677
31. Joyner R.W., Ramza B.M., Osaka T., et al. Cellular mechanisms of delayed recovery of excitability in ventricular tissue. Am J Physiol 260 (1991) H225-H233
32. Luo C.H., and Rudy Y. A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circ Res 74 (1994) 1071-1096
33. Aomine M. Tetrodotoxin-sensitive component in action potential plateau of guinea pig Purkinje fibers: comparison with the papillary muscle. Gen Pharmacol 20 (1989) 791-797
34. Sipido K.R., Carmeliet E., and Pappano A. Na+ current and Ca2+ release from the sarcoplasmic reticulum during action potentials in guinea-pig ventricular myocytes. J Physiol 489 (1995) 1-17
35. Bassani J.W., Yuan W., and Bers D.M. Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes. Am J Physiol 268 (1995) C1313-C1319
36. Santana L.F., Kranias E.G., and Lederer W.J. Calcium sparks and excitation-contraction coupling in phospholamban-deficient mouse ventricular myocytes. J Physiol 503 (1997) 21-29
37. Ferrier G.R., Redondo I.M., Mason C.A., et al. Regulation of contraction and relaxation by membrane potential in cardiac ventricular myocytes. Am J Physiol Heart Circ Physiol 278 (2000) H1618-H1626
38. Trafford A.W., Diaz M.E., Negretti N., et al. Enhanced Ca2 + current and decreased Ca2 + efflux restore sarcoplasmic reticulum Ca2 + content after depletion. Circ Res 81 (1997) 477-484
39. Eisner D.A., Lederer W.J., and Sheu S.S. The role of intracellular sodium activity in the anti-arrhythmic action of local anaesthetics in sheep Purkinje fibres. J Physiol 340 (1983) 239-257
40. 2+ concentrations. J Gen Physiol 107 (1996) 459-472
41. Blaustein M.P., and Lederer W.J. Sodium/calcium exchange: its physiological implications. Physiol Rev 79 (1999) 763-854
42. 2+ release in cardiac myocytes by changes in repolarization rate: role of phase-1 action potential repolarization in excitation-contraction coupling. Circ Res 90 (2002) 165-173
43. Saint D.A., Ju Y.K., and Gage P.W. A persistent sodium current in rat ventricular myocytes. J Physiol 453 (1992) 219-231
44. Sakmann B.F., Spindler A.J., Bryant S.M., et al. Distribution of a persistent sodium current across the ventricular wall in guinea pigs. Circ Res 87 (2000) 910-914
45. Wasserstrom J.A., and Salata J.J. Basis for tetrodotoxin and lidocaine effects on action potentials in dog ventricular myocytes. Am J Physiol 254 (1988) H1157-H1166
46. Maier S.K., Westenbroek R.E., Schenkman K.A., et al. An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart. Proc Natl Acad Sci U S A 99 (2002) 4073-4078
47. Maurice N., Tkatch T., Meisler M., et al. D1/D5 dopamine receptor activation differentially modulates rapidly inactivating and persistent sodium currents in prefrontal cortex pyramidal neurons. J Neurosci 21 (2001) 2268-2277
48. Gomez A.M., Valdivia H.H., Cheng H., et al. Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science 276 (1997) 800-806
49. Marks A.R. Ryanodine receptors/calcium release channels in heart failure and sudden cardiac death. J Mol Cell Cardiol 33 (2001) 615-624
50. Marx S.O., Reiken S., Hisamatsu Y., et al. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 101 (2000) 365-376
51. Preliminary report. Effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. The Cardiac Arrhythmia Suppression Trial (CAST) Investigators. N Engl J Med 321 (1989) 406-412
52. Puglisi J.L., and Bers D.M. LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport. Am J Physiol Cell Physiol 281 (2001) C2049-C2060