Blood pressure in mutant rats lacking the 5-hydroxytryptamine transporter [7]

Hypertension

Volumn 48, Issue 6, 2006, Pages

  Homberg, Judith ^a   Mudde, Josine ^a   Braam, Branko ^b   Ellenbroek, Bart ^c   Cuppen, Edwin ^a   Joles, Jaap A ^d  

^a HUBRECHT INSTITUTE   (Netherlands)

^b UNIVERSITY OF ALBERTA   (Canada)

^c RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; ETHYLNITROSOUREA; NITRIC OXIDE; SEROTONIN; SEROTONIN TRANSPORTER; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; BLOOD PRESSURE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENZYME IMMUNOASSAY; FEMALE; GENE INACTIVATION; GENOTYPE; HEMODYNAMICS; HOMOZYGOSITY; HYPERTENSION; KIDNEY INJURY; LETTER; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; RAT; RAT STRAIN; STOP CODON; SYSTOLIC BLOOD PRESSURE; THROMBOCYTE; UREA BLOOD LEVEL; VASCULAR SMOOTH MUSCLE;

ANIMALS; BLOOD PRESSURE; GENE EXPRESSION; HYPERTENSION; MICE; MICE, KNOCKOUT; RATS; RATS, WISTAR; RNA-BINDING PROTEINS;

EID: 33751116818     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000246306.61289.d8     Document Type: Letter

References (6)

1. Watts SW. 5-HT in systemic hypertension: foe, friend or fantasy? Clin Sci (Lond). 2005;108:399-412.
2. Ni W, Lookingland K, Watts SW. Arterial 5-hydroxytryptamine transporter function is impaired in deoxycorticosterone acetate and N{omega}-nitro-L- arginine but not spontaneously hypertensive rats. Hypertension. 2006;48:134-140.
3. Chon H, Gaillard CA, van der Meijden BB, Dijstelbloem HM, Kraaijenhagen RJ, van Leenen D, Holstege FC, Joles JA, Bluyssen HA, Koomans HA, Braam B. Broadly altered gene expression in blood leukocytes in essential hypertension is absent during treatment. Hypertension. 2004;43:947-951.
4. Smits BM, Mudde JB, van de Belt J, Verheul M, Olivier J, Homberg J, Guryev V, Cools AR, Ellenbroek BA, Plasterk RH, Cuppen E. Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis. Pharmacogenet Genomics. 2006;16:159-169.
5. Attia DM, Verhagen AM, Stroes ES, van Faassen EE, Grone HJ, De Kimpe SJ, Koomans HA, Braam B, Joles JA. Vitamin E alleviates renal injury, but not hypertension, during chronic nitric oxide synthase inhibition in rats. J Am Soc Nephrol. 2001;12:2585-2593.
6. Eddahibi S, Hanoun N, Lanfumey L, Lesch KP, Raffestin B, Hamon M, Adnot S. Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene. J Clin Invest. 2000;105:1555-1562.