The importance of gene-environment interactions and exposure assessment in understanding human diseases

Journal of Exposure Science and Environmental Epidemiology

Volumn 16, Issue 6, 2006, Pages 474-476

  Schwartz, David A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLATION; DNA SEQUENCE; EDITORIAL; ENVIRONMENTAL FACTOR; EPIGENETICS; GENE EXPRESSION; GENOME IMPRINTING; HEREDITY; HUMAN; METABOLOMICS; PROTEIN PROCESSING; PROTEOMICS; RISK ASSESSMENT; RISK FACTOR;

CASE-CONTROL STUDIES; DISEASE; ENVIRONMENT; ENVIRONMENTAL EXPOSURE; GENES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; RISK FACTORS;

EID: 33751101568     PISSN: 15590631     EISSN: 1559064X     Source Type: Journal    
DOI: 10.1038/sj.jes.7500531     Document Type: Editorial

References (12)

1. Anway M.D., Cupp A.S., Uzumcu M., and Skinner M.K. Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science 2005: 308: 1466-1469.
2. Arbour N.C., Lorenz E., Schutte B.C., Zabner J., Kline J.N., Jones M., Frees K., Watt J.L., and Schwartz D.A. TLR4 mutation is associated with endotoxin hyporesponsiveness in humans. Nat Genet 2002: 25: 187-191.
3. Beck S., Olek A., and Walter J. From genomics to epigenomics: a loftier view of life. Nat Biotechnol 1999: 17: 1144.
4. Cook D.N., Pisetsky D.S., and Schwartz D.A. Toll-like receptors in the pathogenesis of human disease. Nat Immunol 2004: 5: 975-979.
5. Dolinoy D.C., Weidman J.R., Waterland R.A., and Jirtle R.L. Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ Health Perspec 2006: 114: 567-572.
6. Fraga M.F., Ballestar E., Paz M.F., Ropero S., Setien F., Ballestar M.L., Heine-Suner D., Cigudosa J.C., Urioste M., Benitez J., et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA 2005: 102: 10604-10609.
7. Hoffman C., Rice D., and Sung H.-Y. Persons with chronic conditions: their prevalence and costs. JAMA 1996: 276: 1473-1479.
8. Jones P.A., and Martienssen R. A blueprint for a Human Epigenome Project: the AACR Human Epigenome workshop. Cancer Res 2005: 65: 11241-11246.
9. Lichtenstein P., Holm N.V., Verkasalo P.K., Iliadou A., Kaprio J., Koskenvuo M., Pukkala E., Skytthe A., and Hemminki K. Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 2000: 343: 78-85.
10. Powell J.J., Van de Water J., and Gershwin M.E. Evidence for the role of environmental agents in the initiation or progression of autoimmune conditions. Environ Health Perspect 1999: 107: 667-672.
11. Tanner C.M., Ottman R., Goldman S.M., Ellenberg J., Chan P., Mayeux R., and Langston J.W. Parkinsondi sease int wins: an etiologic study. JAMA 1999: 281: 341-346.
12. Waterland R.A., and Jirtle R.L. Transposable elements: targets for early nutritional effects on epigenetic gene regulation.Mol Cell Biol 2003: 23: 5293-5300.