Effects of Xiaoke granule on transforming growth factor-beta1, expression and proliferation in rat mesangial cells

Chinese Medical Journal

Volumn 119, Issue 21, 2006, Pages 1839-1842

  Ji, Xiao Mei ^a   Wang, Qian ^b   Gong, Mu Xin ^a   Du, Yu Qiong ^a   Jia, De Xian ^b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Chinese medicine; Mesangial cell; Rat; Transforming growth factor beta

Indexed keywords

CHINESE DRUG; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; XIAOKE;

ANALYSIS OF VARIANCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DOWN REGULATION; DRUG BLOOD LEVEL; GLOMERULUS; KIDNEY PARENCHYMA; MALE; MESANGIUM CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; TISSUE CULTURE; TISSUE PREPARATION;

EID: 33751098761     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200611010-00013     Document Type: Article

References (16)

1. Cohen MP, Chen S, Ziyadeh FN, Shea E, Hud EA, Lautenslager GT, et al. Evidence linking glycated albumin to altered glomerular nephrin and VEGF expression, proteinuria, and diabetic nephropathy. Kidney Int 2005; 68: 1554-1561.
2. Banes AK, Shaw S, Jenkins J, Redd H, Amiri F, Pollock DM, et al. Angiotensin II blockade prevents hyperglycemia-induced activation of JAK and STAT proteins in diabetic rat kidney glomeruli. Am J Physiol Renal Physiol 2004; 286: F653-659.
3. Ji XM, Wang Q, Qi F, Wang YX, Yu M, Huang QF, et al. Effect of Xiaoke graule on blood glucose, urinary protein and glomerular morphology in rats with diabetic nephropathy. Chin J Integr Tradit West Med (Chin) 2004; 24: 534-537.
4. Wang Q, Gong MX, Zhao H, Wang YX, Yu M, Li KL, et al. Influence of Xiaoke Keli ji on glycemia and serum lipoprotein levels in diabetic nephropathy rats. Chin J Pathophysiol (Chin) 2003; 19: 664-667.
5. Wendt TM, Tanji N, Guo J, Kislinger TR, Qu W, Lu Y, et al. RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy. Am J Pathol 2003; 162: 1123-1137.
6. 1 synthesis via an autocrine PDGF loop. Am J Pathol 2003; 163: 2565-2574.
7. Wolf G, Sharma K, Chen Y, Ericksen M, Ziyaheh FN. High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β. Kidney Int 1992; 42: 647-656.
8. Wang Q, Yu M, Gong MX, Huang QF, Li KL, Chai XL, et al. Effects of high glucose on proliferation of cultured rat mesangial cells. Chin J Pathophysiol (Chin) 2003; 19: 1691-1692.
9. Nahman NS Jr, Leonhart KL, Cosio FG, Hebert CL. Effects of high glucose on cellular proliferation and fibronectin production by cultured human mesangial cells. Kidney Int 1992; 41: 396-402.
10. Poncelet AC, de Caestecker MP, Schnaper HW. The transforming growth factor-beta/SMAD signaling pathway is present and functional in human mesangial cells. Kidney Int 1999; 56: 1354-1365.
11. Lee HS, Kim BC, Hong HK, Kim YS. LDL stimulates collagen mRNA synthesis in mesangial cells through induction of PKC and TGF-beta expression. Am J Physiol 1999; 277: F369-376.
12. 2 in rat glomeruli. Kidney Int 1990; 38: 1095-1100.
13. 1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF. J Am Soc Nephrol 2004; 15: 1402-1412.
14. Wahab NA, Schaefer L, Weston BS, Yiannikouris O, Wright A, Babelova A, et al. Glomerular expression of thrombospondin-1, transforming growth factor beta and connective tissue growth factor at different stages of diabetic nephropathy and their interdependent roles in mesangial response to diabetic stimuli. Diabetologia 2005; 48: 2650-2660.
15. Chow FY, Nikolic-Paterson DJ, Ozols E, Atkins RC, Tesch GH. Intercellular adhesion molecule-1 deficiency is protective against nephropathy in type 2 diabetic db/db mice. J Am Soc Nephrol 2005; 16: 1711-1722.
16. Hill C, Flyvbjerg A, Gronbaek H, Petrik J, Hill DJ, Thomas CR, et al. The renal expression of transforming growth factor-beta isoforms and their receptors in acute and chronic experimental diabetes in rats. Endocrinology 2000; 141: 1196-1208.