Effect of recombinant hGH (rhGH) replacement on gonadal function in male patients with organic adult-onset GH deficiency

Clinical Endocrinology

Volumn 65, Issue 6, 2006, Pages 717-721

  Giavoli, Claudia ^a   Ferrante, Emanuele ^a   Ermetici, Federica ^b   Bergamaschi, Silvia ^a   Ronchi, Cristina L ^a   Lania, Andrea G ^a   Ambrosi, Bruno ^b   Spada, Anna ^a   Beck Peccoz, Paolo ^a,c  

^a MAGGIORE HOSPITAL   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FOLLITROPIN; GONADORELIN; HUMAN GROWTH HORMONE; LUTEINIZING HORMONE; SEX HORMONE BINDING GLOBULIN; SOMATOMEDIN C; TESTOSTERONE;

ADULT; ARTICLE; BODY FAT; CLINICAL ARTICLE; CONTROLLED STUDY; FOLLITROPIN BLOOD LEVEL; GONAD FUNCTION; GROWTH HORMONE DEFICIENCY; HUMAN; HYPOGONADISM; HYPOPITUITARISM; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; HYPOTHYROIDISM; LUTEINIZING HORMONE BLOOD LEVEL; MALE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; TESTOSTERONE BLOOD LEVEL;

ADULT; AREA UNDER CURVE; BODY COMPOSITION; FOLLICLE STIMULATING HORMONE; GONADOTROPIN-RELEASING HORMONE; HUMAN GROWTH HORMONE; HUMANS; HYPOPITUITARISM; INSULIN-LIKE GROWTH FACTOR I; LUTEINIZING HORMONE; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SEX HORMONE-BINDING GLOBULIN; SOMATOMEDINS; TESTIS; TESTOSTERONE;

EID: 33751088519     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2006.02655.x     Document Type: Article

References (27)

1. Porretti, S., Giavoli, C., Ronchi, C., Lombardi, G., Zaccaria, M., Valle, D., Arosio, M. & Beck-Peccoz, P., on behalf of Ely-Lilly & Co. B9R-EW-GDED Italian Study Group. (2002) Recombinant human GH replacement therapy and thyroid function in a large group of adult GH-deficient patients: when does L-T4 therapy become mandatory? Journal of Clinical Endocrinology and Metabolism, 87, 2042-2045.
2. Giavoli, C., Porretti, S., Ferrante, E., Cappiello, V., Ronchi, C.L., Travaglini, P., Epaminonda, P., Arosio, M. & Beck-Peccoz, P. (2003) Recombinant hGH replacement therapy and hypothalamus-pituitary-thyroid axis in children with GH deficiency: when should we care about the occurrence of central hypothyroidism? Clinical Endocrinology, 59, 806-810.
3. Seminara, S., Stagi, S., Candura, L., Scrivano, M., Lenzi, L., Nanni, L., Pagliai, F. & Chiarelli, F. (2005) Changes of thyroid function during long-term hGH therapy in GHD children. A possible relationship with catch-up growth? Hormone and Metabolic Research, 37, 751-756.
4. Isidori, A.M., Kaltsas, G.A., Perry, L., Burrin, J.M., Besser, G.M. & Monson, J.P. (2003) The effect of growth hormone replacement therapy on adrenal androgen secretion in adult onset hypopituitarism. Clinical Endocrinology, 58, 601-611.
5. Swords, F.M., Carrol, P.V., Kisalu, J., Wood, P.J., Taylor, N.F. & Monson, J.P. (2003) The effects of growth hormone deficiency and replacement on glucocorticoid exposure in hypopituitary patients on cortisone acetate and hydrocortisone replacement. Clinical Endocrinology, 59, 613-620.
6. Giavoli, C., Libè, R., Corbetta, S., Ferrante, E., Lania, A., Arosio, M., Spada, A. & Beck-Peccoz, P. (2004) Effect of recombinant human growth hormone (GH) replacement on the hypothalamic-pituitary-adrenal axis in adult GH-deficient patients. Journal of Clinical Endocrinology and Metabolism, 89, 5397-5401.
7. Juul, A., Andersson, A.M., Pedersen, S.A., Jorgensen, J.O.L., Christiansen, J.S., Groome, N.P. & Skakkebaek, N.E. (1998) Effects of growth hormone replacement therapy on IGF-related parameters and on the pituitary-gonadal axis in GH-deficient males. Hormone Research, 49, 269-278.
8. Carani, C., Granata, A.R.M., De Rosa, M., Garau, C., Zarrilli, S., Paesano, L., Colao, A., Marrama, P. & Lombardi, G. (1999) The effect of chronic treatment with GH on gonadal function in men with isolated GH deficiency. European Journal of Endocrinology, 140, 224-230.
9. Ghigo, E., Aimaretti, G., Giannotti, L., Bellone, J., Arvat, E. & Camanni, F. (1996) New approach to the diagnosis of growth hormone deficiency in adults. European Journal of Endocrinology, 134, 352-356.
10. Sodergard, R., Backstrom, T., Shanbhag, V. & Carstensen, H. (1982) Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature. Journal of Steroid Biochemistry and Molecular Biology, 16, 801-810.
11. Vermeulen, A., Verdonck, L. & Kaufman, J.M. (1999) A critical evaluation of simple methods for the estimation of free testosterone in serum. Journal of Clinical Endocrinology and Metabolism, 84, 3666-3672.
12. Segal, K.R., Van Loan, M., Fitzgerald, P.I., Hodgdon, J.A. & Van Itallie, T.B. (1988) Lean body mass estimation by bioelectrical impedance analysis: a four-site cross validation study. American Journal of Clinical Nutrition, 47, 7-14.
13. Pichard, C., Kyle, U.G., Bracco, D., Slosman, D.O., Morabia, A. & Schutz, Y. (2000) Reference values of fat-free and fat masses by bioelectrical impedance analysis in 3393 healthy subjects. Nutrition, 16, 245-254.
14. Rosner, W., Aden, D.P. & Khan, M.S. (1984) Hormonal influences on the secretion of steroid-binding proteins by human hepatoma-derived cell line. Journal of Clinical Endocrinology and Metabolism, 59, 806-806.
15. Plymate, S.R., Hoop, R.C., Jones, R.E. & Matej, L.A. (1990) Regulation of sex hormone-binding globulin production by growth factors. Metabolism, 39, 967-970.
16. Singh, A., Hamilton-Fairley, D., Koistinen, R., Seppelä, M., James, V.H.T., Franks, S. & Reed, M.J. (1990) Effect of insulin-like growth factor-type I (IGF-I) and insulin on the secretion of sex-hormone binding globulin and IGF-I binding protein (IBP-I) by human hepatoma cells. Journal of Endocrinology, 124, R1-R3.
17. Edmunds, S.E.J., Strubbs, A.P., Santos, A.A. & Wilkinson, M.L. (1990) Estrogen and androgen regulation of sex hormone-binding globulin secretion by a human liver cell line. Journal of Steroid Biochemistry and Molecular Biology, 37, 733-739.
18. Raggatt, L.E., Blok, R.B., Hamblin, P.S. & Barlow, J.W. (1992) Effects of thyroid hormone on sex hormone-binding globulin gene expression in human cells. Journal of Clinical Endocrinology and Metabolism, 75, 116-120.
19. De Moor, P., Heyns, W. & Bouillon, R. (1972) Growth hormone and the steroid binding,-globulin of human plasma. Journal of Steroid Biochemistry and Molecular Biology, 3, 593-600.
20. Anderson, D.C. (1974) Sex hormone-binding globulin. Clinical Endocrinology, 3, 69-96.
21. Gafny, M., Silbergeld, A., Klinger, B., Wasserman, M. & Laron, Z. (1994) Comparative effects of GH, IGF-I and insulin on serum sex-hormone binding globulin. Clinical Endocrinology, 41, 169-175.
22. Tapanainen, J., Martikainen, H., Voutilainen, R., Orava, M., Roukonen, A. & Ronnberg, L. (1992) Effect of growth hormone administration on human ovarian function and steroidogenic gene expression in granulosa-luteal cell. Fertility and Sterility, 58, 726-732.
23. Oscarsson, J., Göran, L., Per-Arne, L. & Edén, S. (1996) Continuous subcutaneous infusion of low dose growth hormone decreases sex-hormone binding globulin and testosterone concentrations in moderately obese middle-aged men. Clinical Endocrinology, 44, 23-29.
24. Belgorsky, A., Martinez, A., Domene, H., Heinrich, J.J., Bergada, C. & Rivarola, M.A. (1987) High serum sex hormone-binding globulin (SHBG) and low serum non-SHBG-bound testosterone in boys with idiopathic hypopituitarism: effect of recombinant human growth hormone treatment. Journal of Clinical Endocrinology and Metabolism, 65, 1107-1111.
25. Leifke, E., Gorenoi, V., Wichers, C., von zur Mühlen, A., von Büren, E. & Barbant, G. (2000) Age-related changes of serum sex hormones, insulin-like growth factor-1 and sex-hormone binding globulin levels in men: cross sectional data from a healthy male cohort. Clinical Endocrinology, 53, 689-695.
26. Coro, J.F., Poulos, J., Ittop, O., Pories, W.J., Flickinger, E.G. & Sinha, M.K. (1988) Insulin-like growth factor-I binding in hepathocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liver. Journal of Clinical Investigation, 81, 976-981.
27. Hubina, E., Mersebach, H., Rasmussen, A.K., Juul, A., Bjerregaard Sneppen, S., Goth, M.I. & Feldt-Rasmussen, U. (2003) Effect of growth hormone replacement therapy on pituitary hormone secretion and hormone replacement therapies in GHD adults. Hormone Research, 61, 211-217.