Clonal heterogeneity of tumor may be due to continuous influx of newly transformed cells

Cancer Biology and Therapy

Volumn 5, Issue 10, 2006, Pages 1263-1264

  Lichtenstein, Anatoly V ^a  

^a Cancer Research Center   (Russian Federation)

Author keywords

Cancer; Clonal heterogeneity; Mutation rate; Tumor progression

Indexed keywords

CANCER CELL; CANCER GENETICS; CANCER GROWTH; CANCER STAGING; CARCINOGENESIS; CELL DIVISION; CELL HETEROGENEITY; CELL MUTANT; CELL POPULATION; CELL TRANSFORMATION; CLINICAL FEATURE; DIAGNOSTIC TEST; DNA DAMAGE; GENE MUTATION; GENOTYPE; MOLECULAR CLONING; MOLECULAR EVOLUTION; PHENOTYPE; PRECANCER; PROTEIN EXPRESSION; SHORT SURVEY; STEM CELL; SURGEON;

EID: 33751079603     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.5.10.3347     Document Type: Short Survey

References (10)

1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100:57-70.
2. Lichtenstein AV. On evolutionary origin of cancer. Cancer Cell Int 2005; 5:5, (http://www.cancerci.com/content/5/1/5).
3. Futreal PA, Coin L, Marshall M, Down T, Hubbard T, Wooster R, Rahman N, Stratton MR. A census of human cancer genes. Nat Rev Cancer 2004; 4:177-83.
4. Tomlinson IP, Novelli MR, Bodmer WF. The mutation rate and cancer. Proc Natl Acad Sci USA 1996; 93:14800-803.
5. Loeb LA. A mutator phenotype in cancer. Cancer Res 2001; 61:3230-39.
6. Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004; 10:789-99.
7. Kim R, Emi M, Tanabe K, Arihiro K. Tumor-driven evolution of immunosuppressive networks during malignant progression. Cancer Res 2006; 66:5527-36.
8. Kulbe H, Levinson NR, Balkwill F, Wilson JL. The chemokine network in cancer - Much more than directing cell movement. Int J Dev Biol 2004; 48:489-96.
9. Limoli CL, Giedzinski E, Morgan WF, Swarts SG, Jones GD, Hyun W. Persistent oxidative stress in chromosomally unstable cells. Cancer Res 2003; 63:3107-14.
10. Braakhuis BJM, Tabor MP, Kummer JA, Leemans CR, Brakenhoff RH. A genetic explanation of Slaughter's concept of field cancerization: Evidence and clinical implications. Cancer Res 2003; 63:1727-30.