Antibody Buffering in the Brain

Journal of Molecular Biology

Volumn 364, Issue 5, 2006, Pages 1003-1009

  O'Hear, Carol ^a   Foote, Jefferson ^b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b Arrowsmith Technologies   (United States)

Author keywords

antibody; antibody buffering; drug delivery; intracranial therapy; pharmacokinetics

Indexed keywords

AMINOBUTYRIC ACID DERIVATIVE; ANTIBODY; BUFFER; HAPTEN 2 PHENYLOXAZOL 5 ONE METHYLENE GAMMA AMINOBUTYRATE; OX ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG ELIMINATION; DRUG HALF LIFE; DRUG INFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 33751073720     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.09.029     Document Type: Article

References (22)

1. O'Hear C.E., and Foote J. Antibody buffering of a ligand in vivo. Proc. Natl Acad. Sci. USA 102 (2005) 40-44
2. Heideman R.L., Packer R.J., Albright L.A., Freeman C.R., and Rorke L.B. Tumors of the central nervous system. In: Pizzo P.A., and Poplack D.G. (Eds). Principles and Practice of Pediatric Oncology. 3rd edit. (1997), Lippincott-Raven, Philadelphia 633-697
3. Chauhan N.B., Siegel G.J., and Lichtor T. Distribution of intraventricularly administered antiamyloid-beta peptide (Aβ) antibody in the mouse brain. J. Neurosci. Res. 66 (2001) 231-235
4. Deane R., Sagare A., Hamm K., Parisi M., LaRue B., Guo H., et al. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J. Neurosci. 14 (2005) 11495-11503
5. Castro M.G., Cowen R., Williamson I.K., David A., Jimenez-Dalmaroni M.J., Yuan X., et al. Current and future strategies for the treatment of malignant brain tumors. Pharmacol. Ther. 98 (2003) 71-108
6. Rubenstein J.L., Combs D., Rosenberg J., Levy A., McDermott M., Damon L., et al. Rituximab therapy for CNS lymphomas: targeting the leptomeningeal compartment. Blood 101 (2003) 466-468
7. Muraszko K., Sung C., Walbridge S., Greenfield L., Dedrick R.L., Oldfield E.H., and Youle R.J. Pharmacokinetics and toxicology of immunotoxins administered into the subarachnoid space in nonhuman primates and rodents. Cancer Res. 53 (1993) 3752-3757
8. Pell J.M., Johnsson I.D., Pullar R.A., Morrell D.J., Hart I.C., Holder A.T., and Aston R. Potentiation of growth hormone activity in sheep using monoclonal antibodies. J. Endocrinol. 120 (1989) R15-R18
9. Mihara M., Koishihara Y., Fukui H., Yasukawa K., and Ohsugi Y. Murine anti-human IL-6 monoclonal antibody prolongs the half-life in circulating blood and thus prolongs the bioactivity of human IL-6 in mice. Immunology 74 (1991) 55-59
10. Finkelman F.D., Madden K.B., Morris S.C., Holmes J.M., Boiani N., Katona I.M., and Maliszewski C.R. Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes. J. Immunol. 151 (1993) 1235-1244
11. May L.T., Neta R., Moldawer L.L., Kenney J.S., Patel K., and Sehgal P.B. Antibodies chaperone circulating IL-6. Paradoxical effects of anti-IL-6 "neutralizing" antibodies in vivo. J. Immunol. 151 (1993) 3225-3236
12. Griffiths N.M., Hewick D.S., and Stevenson I.H. The effect of immunization with digoxin-specific antibodies on digoxin disposition in the mouse. Biochem. Pharmacol. 33 (1984) 3041-3046
13. Rehlander B.N., and Cho M.J. Anti-drug antibodies as drug carriers. I. For small molecules. Pharm. Res. 18 (2001) 745-752
14. van den Berg M.P., Romeijn S.G., Verhoef J.C., and Merkus F.W. Serial cerebrospinal fluid sampling in a rat model to study drug uptake from the nasal cavity. J. Neurosci. Methods 116 (2002) 99-107
15. Foote J., and Milstein C. Kinetic maturation of an immune response. Nature 352 (1991) 530-532
16. Amit A.G., Mariuzza R.A., Phillips S.E.V., and Poljak R.J. Three-dimensional structure of an antigen-antibody complex at 2.8 Å resolution. Science 233 (1986) 747-753
17. Bigner D.D., Brown M., Coleman R.E., Friedman A.H., Friedman H.S., McLendon R.E., et al. Phase I studies of treatment of malignant gliomas and neoplastic meningitis with 131I-radiolabeled monoclonal antibodies anti-tenascin 81C6 and anti-chondroitin proteoglycan sulfate Me1-14 F (ab')2-a preliminary report. J. Neurooncol. 24 (1995) 109-122
18. Griffiths G.M., Berek C., Kaartinen M., and Milstein C. Somatic mutation and the maturation of immune response to 2-phenyl oxazolone. Nature 312 (1984) 271-275
19. Berek C., Jarvis J.M., and Milstein C. Activation of memory and virgin B cell clones in hyperimmune animals. Eur. J. Immunol. 17 (1987) 1121-1129
20. Hunter W.M., and Greenwood F.C. Preparation of Iodine-131 labelled human growth hormone of high specific activity. Nature 194 (1962) 495-496
21. McConahey P.J., and Dixon F.J. Radioiodination of proteins by the use of the Chloramine-T method. Methods Enzymol. 70 (1980) 210-213
22. Yelton D.E., Desaymard C., and Scharff M.D. Use of monoclonal anti-mouse immunoglobulin to detect mouse antibodies. Hybridoma 1 (1981) 5-11