Dependence of intramyocardial pressure and coronary flow on ventricular loading and contractility: A model study

Annals of Biomedical Engineering

Volumn 34, Issue 12, 2006, Pages 1833-1845

  Bovendeerd, Peter H M ^a   Borsje, Petra ^a   Arts, Theo ^a,b   Van De Vosse, Frans N ^a  

^a EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Empty beating heart; Intramyocardial pump; Lumped parameter model; Radial wall stress; Ventricular mechanics

Indexed keywords

BIOLOGICAL ORGANS; BLOOD; FLOW OF FLUIDS; MATHEMATICAL MODELS; PARAMETER ESTIMATION; PRESSURE EFFECTS; SENSITIVITY ANALYSIS; STRESS ANALYSIS;

EMPTY BEATING HEART; INTRAMYOCARDIAL PUMPS; LUMPED PARAMETER MODELS; RADIAL WALL STRESS; VENTRICULAR MECHANICS;

BIOMEDICAL ENGINEERING;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; BLOOD PRESSURE; HEART CONTRACTION; HEART MUSCLE; HEART VENTRICLE; HEART VENTRICLE FUNCTION; HUMAN; PHYSIOLOGY;

ANIMALS; BLOOD PRESSURE; HEART VENTRICLES; HUMANS; MODELS, CARDIOVASCULAR; MYOCARDIAL CONTRACTION; MYOCARDIUM; VENTRICULAR FUNCTION;

EID: 33751071324     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-006-9189-2     Document Type: Article

References (30)

1. Arts, T. A mathematical model of the dynamics of the left ventricle and the coronary circulation. PhD Thesis, University of Limburg, Maastricht, The Netherlands, 1978.
2. Arts, T. and R.S. Reneman Interaction between intra-myocardial pressure (IMP) and myocardial circulation. J. Biomech. Eng. 107:51-56, 1985.
3. Arts, T., P. H. M. Bovendeerd, F. W. Prinzen, and R. S. Reneman Relation between left ventricular cavity pressure and volume and systolic fiber stress and strain in the wall. Biophys. J. 59:93-102, 1991.
4. Bassingthwaighte, J. B., D. A. Beard, and Z. Li The mechanical and metabolic basis of myocardial blood flow heterogeneity. Basic Res. Cardiol. 96:582-594, 2001.
5. Beyar, R., R. Ben-Ari, C. A. Gibbons-Kroeker, J. V. Tyberg, and S. Sideman Effect of interconnecting collagen fibers on left ventricular function and intramyocardial compression. Cardiovasc. Res. 27:2252-2263, 1993.
6. Bruinsma, P., T. Arts, J. Dankelman, and J. A. Spaan Model of the coronary circulation based on pressure dependence of coronary resistance and compliance. Basic Res. Cardiol. 83:510-524, 1988.
7. Chilian, W. M., S. M. Layne, E. C. Klausner, C. L. Eastham, and M. L. Marcus Redistribution of coronary microvascular resistance produced by dipyridamole. Am. J. Physiol. 256:H383-H390, 1989.
8. de Tombe, P. P. and H. E. D. J. ter Keurs Sarcomere dynamics in cat cardiac trabeculae. Circ. Res. 68:588-596, 1991.
9. Downey, E. M. and E. S. Kirk Inhibition of coronary blood flow by a vascular waterfall mechanism. Circ. Res. 34:251-257, 1975.
10. Fokkema, D. S., J. W. Van Teeffelen, S. Dekker, I. Vergroesen, J. B. Reitsma, and J. A. Spaan Diastolic time fraction as a determinant of subendocardial perfusion. Am. J. Physiol. 288:H2450-H2456, 2005.
11. Giezeman, M. J., E. van Bavel, C. A. Grimbergen, and J. A. Spaan Compliance of isolated porcine coronary small arteries and coronary pressure-flow relations. Am. J. Physiol. 267:H1190-H1198, 1994.
12. Huyghe, J. M., T. Arts, D. H. van Campen, and R.S. Reneman Porous medium finite element model of the beating left ventricle. Am. J. Physiol. 262:H1256-H1267, 1992.
13. Janssen, P. M. and W. C. Hunter Force, not sarcomere length, correlates with prolongation of isosarcometric contraction. Am. J. Physiol. 269:H676-H685, 1995.
14. Kouwenhoven, Ee, I. Vergroesen, Yi Han, and J. A. Spaan Retrograde coronary flow is limited by time-varying elastance. Am. J. Physiol. 263:H484-H490, 1992.
15. Krams, R., P. Sipkema, and N. Westerhof Varying elastance concept may explain coronary systolic flow impediment. Am. J. Physiol. 257:H1471-H1479, 1989.
16. Krams, R., P. Sipkema, J. Zegers, and N. Westerhof Contractility is the main determinant of coronary systolic flow impediment. Am. J. Physiol. 257:H1936-H1944, 1989.
17. Krams, R., A. C. T. A. van Haelst, P. Sipkema, and N. Westerhof Can coronary systolic-diastolic flow differences be predicted by left ventricular pressure or time-varying intramyocardial elastance?. Basic Res. Cardiol. 84:149-159, 1989.
18. Mihailescu, L. S. and F. L. Abel Intramyocardial pressure gradients in working and nonworking isolated cat hearts. Am. J. Physiol. 266:H1233-H1241, 1994.
19. Nikolić, S., E. L. Yellin, K. Tamura, H. Vetter, T. Tamura, J. S. Meisner, and R. W. M. Frater Passive properties of canine left ventricle: Diastolic stiffness and restoring forces. Circ. Res. 62:1210-1222, 1988.
20. Pagliaro, P., D. Gatullo, R. J. Linden, G. Losano, and N. Westerhof Systolic coronary flow impediment in the dog: Role of ventricular pressure and contractility. Exp. Physiol. 83:821-831, 1998.
21. Rijcken, J., P. H. M. Bovendeerd, A. J. G. Schoofs, D. H. van Campen, and T. Arts Optimization of cardiac fiber orientation for homogeneous fiber strain during ejection. Ann. Biomed. Eng. 27:289-297, 1999.
22. Spaan, J. A., N. P. Breuls, and J. D. Laird Diastolic-systolic coronary flow differences are caused by intramyocardial pump action in the anesthetized dog. Circ. Res. 49:584-93, 1981.
23. Spaan, J. A. E. Coronary diastolic pressure-flow relation and zero flow pressure explained on the basis of intramyocardial compliance. Circ. Res. 56:293-309, 1985.
24. Vendelin, M., P. H. M. Bovendeerd, J. Engelbrecht, and T. Arts Optimizing ventricular fibers: Uniform strain or stress, but not ATP consumption, leads to high efficiency. Am. J. Physiol. 283:H1072-H1081, 2002.
25. Vis, M. A., P. Sipkema, and N. Westerhof Modeling pressure-flow relations in cardiac muscle in diastole and systole. Am. J. Physiol. 272:H1516-H1526, 1997.
26. Vis, M. A., P. H. M. Bovendeerd, P. Sipkema, and N. Westerhof Effect of ventricular contraction, pressure, and wall stretch on vessels at different locations in the wall. Am. J. Physiol. 272:H2963-H2975, 1997.
27. Vis, M. A., P. Sipkema, and N. Westerhof Compression of intramyocardial arterioles during cardiac contraction is attenuated by accompanying venules. Am. J. Physiol. 273:H1003-H1011, 1997.
28. Yin, F. C. P., R. K. Strumpf, P. H. Chew, and S. L. Zeger Quantification of the mechanical properties of noncontracting canine myocardium under simultaneous biaxial loading. J. Biomech. 20:577-589, 1987.
29. Zinemanas, D., R. Beyar, and S. Sideman Effects of myocardial contraction on coronary blood flow: An integrated model. Ann. Blamed. Eng. 22:638-652, 1994.
30. Zinemanas, D., R. Beyar, and S. Sideman An integrated model of LV muscle mechanics, coronary flow, and fluid and mass transport. Am. J. Physiol. 268:H633-H644, 1995.