Differential transformation of ginsenosides from Panax ginseng by lactic acid bacteria

Journal of Microbiology and Biotechnology

Volumn 16, Issue 10, 2006, Pages 1629-1633

  Chin, Hyun ^a   Lee, Bo Hyun ^a   You, Hyun Ju ^a   Park, Myung Soo ^b,c   Ji, Geun Eog ^a,c  

^a Seoul National University   (South Korea)

^b Anyang Science University   (South Korea)

^c Bifido Co   (South Korea)

Author keywords

Ginsenosides; Lactic acid bacteria; Transformation

Indexed keywords

20 O BETA DEXTRO GLUCOPYRANOSYL 20 PROTOPANAXADIOL; BACTERIAL ENZYME; COMPOUND K; GINSENG EXTRACT; GINSENOSIDE; GINSENOSIDE F 1; GINSENOSIDE F 2; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RC; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RF; GINSENOSIDE RG 1; GINSENOSIDE RG 2; GINSENOSIDE RG 3; GINSENOSIDE RH 1; GINSENOSIDE RH 2; MICROBIAL ENZYME; SAPONIN; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM TRANSFORMATION; BIFIDOBACTERIUM; BIOTRANSFORMATION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG IDENTIFICATION; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SUBSTRATE; FEASIBILITY STUDY; GINSENG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LACTIC ACID BACTERIUM; LACTOBACILLUS DELBRUECKII; LEUCONOSTOC MESENTEROIDES; NONHUMAN;

BIFIDOBACTERIUM SP.; LACTOBACILLUS DELBRUECKII; LEUCONOSTOC MESENTEROIDES; PANAX GINSENG;

EID: 33751028950     PISSN: 10177825     EISSN: 17388872     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Akao, T., M. Kanaoka, and K. Kobashi. 1998. Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration - Measurement of compound K by enzyme immunoassay. Biol. Pharm. Bull. 21: 245-249.
2. Akao, T., H. Kida, M. Kanaoka, M. Hattori, and K. Kobashi. 1998. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J. Pharm. Pharmacol. 50: 1155-1160.
3. Bae, E. A., S. Y. Park, and D. H. Kim. 2000. Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol. Pharm. Bull. 23: 1481-1485.
4. Bae, E. A., M. J. Han, M. K. Choo, S. Y. Park and D. H. Kim. 2002. Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities. Biol. Pharm. Bull. 25: 58-63.
5. Chang, H. M. 1986. Pharmacology and Application of Chinese Material Medica. Vol 1. World Scientific, Singapore.
6. Choi, E. K. and G. E. Ji. 2005. Food microorganisms that effectively hydrolyze O-glycoside but not C-glycoside isoflavones in Puerariae radix. J. Food Sci. 70: C25-C28.
7. Han, B. H., M. H. Park Y. N. Han, L. K. Woo, U. Sankawa, S. Yahara, and O. Tanaka. 1982. Degradation of ginseng saponins under mild acidic conditions. Planta Med. 44: 146-149.
8. Hasegawa, H., J. H. Sung, S. Matsumiya, and M. Uchiyama. 1996. Main ginseng saponin metabolites formed by intestinal bacteria. Planta Med. 62: 453-457.
9. Hasegawa, H., J. W. Sung, and Y. Benno. 1997. Role of human intestinal Prevotela oris in hydrolyzmg ginseng saponins. Planta Med. 63: 436-440.
10. Huang, K. C. 1999. The Pharmacology of Chinese Herbs. CRC Press, Florida.
11. Kanaoda, M., T. Akao, and K. Kobashi. 1994. Metabolism of ginseng saponins, ginsenosides, by human intestinal bacteria. J. Trad. Med. 11: 241-245.
12. Karikura, M., T. Miyase, H. Tanizawa, T. Taniyama, and Y. Takino. 1991. Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside-Rb1 and -Rb2 in the digestive tract of rats. Chem. Pharm. Bull. 39: 2357-2361.
13. Karikura, M., H. Kato, F. Shimada, and S. Yano. 1992. Studies on the enzyme immunoassay of bioactive constituents contained in oriental medicinal drugs. VI. Enzyme immunoassay of ginsenoside Rb1 from Panax ginseng. Chem. Pharm. Bull. 40: 314-317.
14. Kim, H. Y., J. H. Yang, and G. E. Ji. 2005. Effect of bifidobacteria on production of allergy-related cytokines from mouse spleen cells. J. Microbiol. Biotechnol. 15: 265-268.
15. Ko, S. R., K. J. Choi, K. Uchida, and Y. Suzuki. 2003. Enzymatic preparation of ginsenosides Rg2, Rh1, and F1 from protopanaxatriol-type ginseng saponin mixture. Planta Med. 69: 285-286.
16. Lee, B. H. and G. E. Ji. 2005. Effect of Bifidobacterium cell fractions on IL-6 production in RAW 264.7 macrophage cells. J. Microbiol. Biotechnol. 15: 740-744.
17. Lee, B. H., H. J. You, M. S. Park, B. Kwon, and G. E. Ji. 2006. Transformation of the glycosides from food materials by probiotics and food microorganisms. J. Microbiol. Biotechnol. 16: 497-504.
18. Lee, D. S., Y. S. Kim, C. N. Ko, K. H. Cho, H. S. Bae, K. S. Lee, J. J. Kim, E. K. Park, and D. H. Kim. 2002. Fecal metabolic activities of herbal components to bioactive compounds. Arch. Pharm. Res. 25: 165-169.
19. Lee, F. C. 1992. Facts About Ginseng, the Elixir of Life. Hollyn International, New Jersey.
20. Mochizuki, M., C. Y. Yoo, K. Matsuzawa, K. Sato, I. Saiki, S. Tono-oda, K. Samukiwa, and I. Azuma. 1995. Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside Rb2, 20(R)- and 20(S)-ginsenoside Rg3, of Red ginseng. Biol. Pharm. Bull. 18: 1197-1202.
21. Park, S. Y., G. E. Ji, Y. T. Ko, H. K. Jung, Z. Ustunol, and J. J. Pestka. 1999. Potentiation of hydrogen peroxide, nitric oxide, and cytokine production in RAW 264.7 macrophage cells exposed to human and commercial isolates of Bifidobacterium. Int. J. Food Microbiol. 46: 231-241.
22. Sato, K., M. Mochizuki, I. Saiki, Y. C. Yoo, K. Samukawa, and I. Azuma. 1994. Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng-ginsenoside Rb2. Biol. Pharm. Bull. 17: 635-639.
23. Tawab, M. A., U. Bahr, M. Karas, M. Wurglics, and M. Schubert-Zsilavecz. 2003. Degradation of ginsenosides in humans after oral administration. Drug Metab. Dispos. 31: 1065-1071.
24. Wu, J. Y., B. H. Gardner, C. I. Murphy, J. R. Seals, C. R. Kensil, J. Recchia, G. A. Beltz, G. W. Newman, and M. J. Newman. 1992. Saponin adjuvant enhancement of antigen-specific immune responses to an experimental HIV-1 vaccine. J. Immunol. 148: 1519-1525.