Cognitive deficits in patients with antiphospholipid syndrome: Association with clinical, laboratory, and brain magnetic resonance imaging findings

Archives of Internal Medicine

Volumn 166, Issue 20, 2006, Pages 2278-2284

  Tektonidou, Maria G ^a   Varsou, Natassa ^a   Kotoulas, Grigorios ^b   Antoniou, Anna ^a   Moutsopoulos, Haralampos M ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b Athens Euroclinic   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; CORTICOSTEROID; IMMUNOMODULATING AGENT; NEUROLEPTIC AGENT;

ADULT; ANTIPHOSPHOLIPID SYNDROME; ARTERY THROMBOSIS; ARTICLE; CLINICAL FEATURE; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; LABORATORY TEST; LIVEDO RETICULARIS; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; NEUROPSYCHIATRY; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PREGNANCY DISORDER; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS; VEIN THROMBOSIS; WHITE MATTER;

ADULT; ANTIPHOSPHOLIPID SYNDROME; CHI-SQUARE DISTRIBUTION; COGNITION DISORDERS; CROSS-SECTIONAL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; LOGISTIC MODELS; MAGNETIC RESONANCE IMAGING; MALE; NEUROPSYCHOLOGICAL TESTS; STATISTICS, NONPARAMETRIC;

EID: 33751021370     PISSN: 00039926     EISSN: 15383679     Source Type: Journal    
DOI: 10.1001/archinte.166.20.2278     Document Type: Article

References (25)

1. Wilson WA, Gharavi AE, Koike T, et al. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum. 1999;42:1309-1311.
2. Sanna G, Bertolaccini ML, Cuadrado MJ, Khamashta MA, Hughes GR. Central nervous system involvement in the antiphospholipid (Hughes) syndrome. Rheumatology (Oxford). 2003;42:200-213.
3. Asherson RA, Mercey D, Phillips G, et al. Recurrent stroke and multi-infarct dementia in systemic lupus erythematosus: association with antiphospholipid antibodies. Ann Rheum Dis. 1987;46:605-611.
4. Gomez-Puerta JA, Cervera R, Calvo LM, et al. Dementia associated with the antiphospholipid syndrome: clinical and radiological characteristics of 30 patients. Rheumatology (Oxford). 2005;44:95-99.
5. Inzelberg R, Bornstein NM, Reider I, Korczyn AD. The lupus anticoagulant and dementia in non-SLE patients. Dementia. 1992;3:140-145.
6. Chapman J, Abu-Katash M, Inzelberg R, et al. Prevalence and clinical features of dementia associated with the antiphospholipid syndrome and circulating anticoagulants. J Neurol Sci. 2002;203-204:81-84.
7. Aharon-Peretz J, Brenner B, Amyel E, et al. Neurocognitive dysfunction in antiphospholipid antibody syndrome (APS) [abstract]. Lupus. 1995;4(suppl 2):101.
8. Mikdashi JA, Kay GG. Neurocognitive deficits in APS [abstract]. Neurology. 1996;46:A359.
9. Hachulla E, Michon-Pasturel U, Leys D, et al. Cerebral magnetic resonance imaging in patients with or without antiphospholipid antibodies. Lupus. 1998;7:124-131.
10. Lezak MD, Howieson DB, Loring DW. Neuropsychological Assessment. 4th ed. New York, NY: Oxford University Press; 2004.
11. Vlachoyiannopoulos PG, Petrovas C, Tektonidou M, Krilis S, Moutsopoulos HM. Antibodies to β2-glycoprotein-I: urea resistance, binding specificity, and association with thrombosis. J Clin Immunol. 1998;18:380-391.
12. Zung WWK. A self-rating depression scale. Arch Gen Psychiatry. 1965;12:63-70.
13. Fazekas F, Chawluk JB, Alavi H, Hurting HI, Zimmerman RA. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol. 1987;149:351-356.
14. Denburg SD, Carbotte RM, Ginsberg JS, Denburg JA. The relationship of antiphospholipid antibodies to cognitive function in patients with systemic lupus erythematosus. J Int Neuropsychol Soc. 1997;3:377-386.
15. Menon S, Jameson-Shortall E, Newman SP, Hall-Graggs MR, Chinn R, Isenberg DA. A longitudinal study of anticardiolipin antibody levels and cognitive functioning in systemic lupus erythematosus. Arthritis Rheum. 1999;42:735-741.
16. Hanly JG, Hong C, Smith S, Fisk J. A prospective analysis of cognitive function and anticardiolipin antibodies in systemic lupus erythematosus. Arthritis Rheum. 1999;42:728-734.
17. Schmidt R, Auer-Grumbach P, Fazekas F, Offenbacher H, Kape P. Anticardiolipin antibodies in normal subjects: neuropsychological correlates and MRI findings. Stroke. 1995;26:749-754.
18. Cervera R, Piette JC, Font J, et al. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1000 patients. Arthritis Rheum. 2002;46:1019-1027.
19. Shoenfeld Y, Nahum A, Korczyn AD, et al. Neuronal-binding antibodies from patients with antiphospholipid syndrome induce cognitive deficits following intrathecal passive transfer. Lupus. 2003;12:436-442.
20. Francès C, Niang S, Laffite E, Pelletrier F, Costedoat N, Piette JC. Dermatologic manifestations of the antiphospholipid syndrome: two hundred consecutive cases. Arthritis Rheum. 2005;52:1785-1793.
21. De Groot JC, De Leeuw FE, Oudkerk M, et al. Periventricular cerebral white matter lesions predict rate of cognitive decline. Ann Neurol. 2002;52:335-341.
22. Roman GC. Vascular dementia prevention: a risk factor analysis. Cerebrovasc Dis. 2005;20:91-100.
23. Stimmler MM, Coletti PM, Quismorio FP Jr. Magnetic resonance imaging of the brain in neuropsychiatric systemic lupus erythematosus. Semin Arthritis Rheum. 1993;22:335-349.
24. Hughson MD, McCarty GA, Brumback RA. Spectrum of vascular pathology affecting patients with the antiphospholipid syndrome. Hum Pathol. 1995;26:716-724.
25. Cervera R, Asherson RA, Lie JT. Clinicopathological correlations of antiphospholipid antibody syndrome. Semin Arthritis Rheum. 1995;24:262-272.