Activation of host-defense mechanism induced by exposure to a low dose of radiation: an approach to accumulate evidence on the interaction between the whole body and radiation

International Journal of Low Radiation

Volumn 1, Issue 2, 2004, Pages 180-188

  Matsubara, Junko ^a,b   Yonezawa, Morio ^c  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b Cabinet Office   (Japan)

^c Osaka Prefecture University   (Japan)

Author keywords

activation of immune function (PFC); apoptosis; low dose; mice; plaque forming cell counts; pre irradiation; survival

Indexed keywords

EID: 33751020213     PISSN: 14776545     EISSN: 17419190     Source Type: Journal    
DOI: 10.1504/IJLR.2004.003869     Document Type: Article

References (15)

1. Yonezawa, M., Takeda, A. and Misonoh, J. (1990) ‘Acquired radioresistance after low dose X-irradiation in mice’, J. Radiat. Res., Vol. 31, pp.256–262.
2. Yonezawa, M., Misonoh, J. and Hosokawa, Y. (1996) ‘Two types of X-ray induced radioresistance after low dose X-irradiation in mice: Presence of 4 dose ranges with distinct biological effects’, Mutation Res., Vol. 358, pp.237–243.
3. Matsubara, J., Tajima, Y. and Karasawa, M. (1987) ‘Metallothionein induction as a potent means of radiation protection in mice’, Radiat. Res., Vol. 111, pp.267–275.
4. Matsubara, J, Tajima, Y. and Karasawa, M. (1987) ‘Promotion of radioresistance by Metallothionein induction prior to irradiation’, Environmental Res., Vol. 43, pp.66–74.
5. Matsubara, J. (1987) ‘Alteration of radiosensitivity in metallothionein induced mice and a possible role of Zn-Cu-thionein in GSH-peroxidase system’ in Kagi, J.H.R. et al. (Eds.): Metallothionein II Experientia Supplementum Vol. 52, Birkhauser Verlag, pp.603–612.
6. Matsubara, J., Tajima, Y., Ikeda, A., Kinoshita, T. and Shimomura, T. (1988) ‘A new perspective of radiation protection by metallothionein induction’, Pharmac. Ther., Vol. 39, pp.331–333.
7. Sasagawa, S., Matsubara, J. and Satow, Y. (1993) ‘Stress-related induction of metallothionein synthesis and increase in peripheral polymorphonuclear leukocytes in mice’, Immunopharm. andImmunotoxicol., Vol. 15, pp.217–226.
8. Miyazaki, T., Matsubara, J., Matsumoto, T. and Khan, H. (1996) ‘Reaction of Metallothionein and long-lived radicals in murine liver’, Radiat. Physics and Chem., Vol. 48, pp.293–296.
9. Matsubara, J., Yoshihara, K., Yamazaki, J. and Eguchi, H. (1992) ‘Hormetic effects produced by the pre-treatment irradiating low-dose radiation or giving stressful stimuli in mice’, in Low Dose Radiation and Biological Defense Mechanisms. Excerpta Medica., Amsterdam and London, pp.427–430.
10. Wolff, S. (1998) ‘Adaptive responses’, Environ. Health Perspect. Vol. 106, pp.277–283.
11. Matsubara, J., Ina, Y and Yamazaki, J. (1993) ‘Comparative study on immunostimulative effects produced by low dose whole body irradiation or metallothionein indusive stressers in mice’, Int. Symp. on Biol. Effects of Low Level Exposures to Radiation Changchun, China.
12. Matsubara, J., Turcanu, V., Poindron, P. and Ina, Y. (2000) ‘Immune effects of low-dose radiation: Short-term induction of thymocyte apoptosis and long-term augmentation of T-cell dependent immune responses’, Radiat. Res., Vol. 153, pp.332–338.
13. Matsubara, J., Turcanu, V., Sugiura, N. and Kosako, T. (2000) ‘Short-time induction of thymocyte apoptosis and long-term augmentation of immune responses by 50 cGy irradiation to mice’, Proceedings of 10th IRPA, May, Hiroshima, Japan.
14. Matsubara, J. (1992) ‘Host defense and hepatic metallothionein induction’, in Shikita, M. and Yamada, T. (Eds.): Induction of Radiation Resistance — Biological and Chemical Means for Radio-protection. Proceedings of the 23rd NIRS Symposium, Chiba, Japan, Dec. 1991, published in Japanese.
15. Yonezawa, M., Takahashi, A., Ohnishi, K., Misonoh, J. and Ohnishi, T. (2000) ‘Suppression of p53 and Bax accumulation after X-irradiation by small dose preirradiation in radioadaptive survival response of C57BL/6 mice’, Proceedings of 10th IRPA, Hiroshima, Japan, May.