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Volumn 12, Issue SUPPL. 6, 2006, Pages 23-29

The epidemiology of factor VIII inhibitors

Author keywords

Epidemiology; Factor VIII; Heredity; Inhibitors; Risk factors

Indexed keywords

BLOOD CLOTTING FACTOR 8 INHIBITOR; HLA DR ANTIGEN; RECOMBINANT BLOOD CLOTTING FACTOR 8;

EID: 33751017726     PISSN: 13518216     EISSN: 13652516     Source Type: Journal    
DOI: 10.1111/j.1365-2516.2006.01362.x     Document Type: Article
Times cited : (65)

References (39)
  • 1
    • 0028899463 scopus 로고
    • The incidence of factor VIII inhibitors in the United Kingdom 1990-1993
    • Colvin BT, Hay CRM, Hill FGH, Preston FE. The incidence of factor VIII inhibitors in the United Kingdom 1990-1993. Br J Haematol 1995; 89: 908-10.
    • (1995) Br J Haematol , vol.89 , pp. 908-910
    • Colvin, B.T.1    Hay, C.R.M.2    Hill, F.G.H.3    Preston, F.E.4
  • 2
    • 0027257566 scopus 로고
    • Frequency of inhibitor development in haemophiliacs treated with low-purity factor VIII
    • Addiego J, Kasper C, Abildgaard C et al. Frequency of inhibitor development in haemophiliacs treated with low-purity factor VIII. Lancet 1993; 342: 462-4.
    • (1993) Lancet , vol.342 , pp. 462-464
    • Addiego, J.1    Kasper, C.2    Abildgaard, C.3
  • 3
    • 0026548917 scopus 로고
    • Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs
    • Ehrenforth S, Kreuz W, Scharrer I et al. Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs. Lancet 1992; 339: 594-8.
    • (1992) Lancet , vol.339 , pp. 594-598
    • Ehrenforth, S.1    Kreuz, W.2    Scharrer, I.3
  • 4
    • 0027473752 scopus 로고
    • Recombinant factor VIII for the treatment of previously untreated patients with hemophilia A. Safety, efficacy, and development of inhibitors
    • Kogenate Previously Untreated Patient Study Group
    • Lusher JM, Arkin S, Abildgaard CF, Schwartz RS. Recombinant factor VIII for the treatment of previously untreated patients with hemophilia A. Safety, efficacy, and development of inhibitors. Kogenate Previously Untreated Patient Study Group. N Engl J Med 1993; 328: 453-9.
    • (1993) N Engl J Med , vol.328 , pp. 453-459
    • Lusher, J.M.1    Arkin, S.2    Abildgaard, C.F.3    Schwartz, R.S.4
  • 5
    • 0028266130 scopus 로고
    • A multicenter study of recombinant factor VIII (recombinate): Safety, efficacy, and inhibitor risk in previously untreated patients with hemophilia A
    • The Recombinate Study Group
    • Bray GL, Gomperts ED, Courter S et al. A multicenter study of recombinant factor VIII (recombinate): Safety, efficacy, and inhibitor risk in previously untreated patients with hemophilia A. The Recombinate Study Group. Blood 1994; 83: 2428-35.
    • (1994) Blood , vol.83 , pp. 2428-2435
    • Bray, G.L.1    Gomperts, E.D.2    Courter, S.3
  • 6
    • 0031958313 scopus 로고    scopus 로고
    • Factor VIII inhibitors in mild and moderate-severity haemophilia A. UK Haemophilia Centre Directors Organisation
    • Hay CR, Ludlam CA, Colvin BT et al. Factor VIII inhibitors in mild and moderate-severity haemophilia A. UK Haemophilia Centre Directors Organisation. Thromb Haemost 1998; 79: 762-6.
    • (1998) Thromb Haemost , vol.79 , pp. 762-766
    • Hay, C.R.1    Ludlam, C.A.2    Colvin, B.T.3
  • 7
    • 0023856830 scopus 로고
    • The natural history of factor VIII: C inhibitors in patients with hemophilia A: A national cooperative study. II. Observations on the initial development of factor VIII: C inhibitors
    • McMillan CW, Shapiro SS, Whitehurst D, Hoyer LW, Rao AV, Lazerson J. The natural history of factor VIII: C inhibitors in patients with hemophilia A: A national cooperative study. II. Observations on the initial development of factor VIII: C inhibitors. Blood 1988; 71: 344-8.
    • (1988) Blood , vol.71 , pp. 344-348
    • McMillan, C.W.1    Shapiro, S.S.2    Whitehurst, D.3    Hoyer, L.W.4    Rao, A.V.5    Lazerson, J.6
  • 8
    • 0026622961 scopus 로고
    • Prevalence of inhibitors in a population of 3435 hemophilia patients in France
    • French Hemophilia Study Group
    • Sultan Y. Prevalence of inhibitors in a population of 3435 hemophilia patients in France. French Hemophilia Study Group. Thromb Haemost 1992; 67: 600-2.
    • (1992) Thromb Haemost , vol.67 , pp. 600-602
    • Sultan, Y.1
  • 9
    • 0017653247 scopus 로고
    • Genetic predisposition to develop factor VIII antibody in classic haemophilia
    • Frommel D, Allain JP. Genetic predisposition to develop factor VIII antibody in classic haemophilia. Clin Immunol Immunopathol 1977; 8: 34-8.
    • (1977) Clin Immunol Immunopathol , vol.8 , pp. 34-38
    • Frommel, D.1    Allain, J.P.2
  • 10
    • 0021314059 scopus 로고
    • Genetic predisposition to inhibitor formation
    • Shapiro SS. Genetic predisposition to inhibitor formation. Prog Clin Biol Res 1984; 150: 45-55.
    • (1984) Prog Clin Biol Res , vol.150 , pp. 45-55
    • Shapiro, S.S.1
  • 11
    • 6644227418 scopus 로고    scopus 로고
    • Further support for genetic predisposition to inhibitor development in hemophilia patients
    • The Malmo International Brother Study (MIBS)
    • Astermark J, Berntorp E, White GC, Kroner BL. The Malmo International Brother Study (MIBS): Further support for genetic predisposition to inhibitor development in hemophilia patients. Haemophilia 2001; 7: 267-72.
    • (2001) Haemophilia , vol.7 , pp. 267-272
    • Astermark, J.1    Berntorp, E.2    White, G.C.3    Kroner, B.L.4
  • 12
    • 0032742545 scopus 로고    scopus 로고
    • The role of genetics in inhibitor formation
    • Gill JC. The role of genetics in inhibitor formation. Thromb Haemost 1999; 2: 500-4.
    • (1999) Thromb Haemost , vol.2 , pp. 500-504
    • Gill, J.C.1
  • 13
    • 22544473061 scopus 로고    scopus 로고
    • Genetic defects and inhibitor development in siblings with severe hemophilia A
    • the MIBS study group. The Malmo International Brother Study (MIBS)
    • Astermark J, Oldenburg J, Escobar M, White GC, Berntorp E, the MIBS study group. The Malmo International Brother Study (MIBS). Genetic defects and inhibitor development in siblings with severe hemophilia A. Haematologica 2005; 90: 924-30.
    • (2005) Haematologica , vol.90 , pp. 924-930
    • Astermark, J.1    Oldenburg, J.2    Escobar, M.3    White, G.C.4    Berntorp, E.5
  • 14
    • 22744433296 scopus 로고    scopus 로고
    • Haemophilia Inhibitor Genetics Study - Evaluation of a model for studies of complex diseases using linkage and associated methods
    • Berntorp E, Astermark J, Doonfield SM et al. Haemophilia Inhibitor Genetics Study -evaluation of a model for studies of complex diseases using linkage and associated methods. Haemophilia 2005; 11: 427-9.
    • (2005) Haemophilia , vol.11 , pp. 427-429
    • Berntorp, E.1    Astermark, J.2    Doonfield, S.M.3
  • 15
    • 0021308824 scopus 로고
    • The natural history of factor VIII inhibitors in patients with haemophilia A
    • In: Hoyer LW, ed. New York: Alan R. Liss
    • Gill FM. The natural history of factor VIII inhibitors in patients with haemophilia A. In: Hoyer LW, ed. Factor VIII Inhibitors. New York: Alan R. Liss, 1984: 19-28.
    • (1984) Factor VIII Inhibitors , pp. 19-28
    • Gill, F.M.1
  • 16
    • 33751012932 scopus 로고
    • Increased frequency of inhibitors in African American hemophilic patients
    • Addiego JE, Kasper C, Abildgaard T et al. Increased frequency of inhibitors in African American hemophilic patients. Blood 1994; 1: 293a.
    • (1994) Blood , vol.1
    • Addiego, J.E.1    Kasper, C.2    Abildgaard, T.3
  • 17
    • 0032787813 scopus 로고    scopus 로고
    • Incidence of inhibitors in haemophilia A patients - A review of recent studies of recombinant and plasma-derived factor VIII concentrates
    • Scharrer I, Bray GL, Neutzling O. Incidence of inhibitors in haemophilia A patients -a review of recent studies of recombinant and plasma-derived factor VIII concentrates. Haemophilia 1999; 5: 145-54.
    • (1999) Haemophilia , vol.5 , pp. 145-154
    • Scharrer, I.1    Bray, G.L.2    Neutzling, O.3
  • 18
    • 30344434999 scopus 로고    scopus 로고
    • Influence of the type of factor VIII concentrate on the incidence of factor VIII inhibitors in previously untreated patients with severe haemophilia A
    • Goudemand J, Rothschild C, Demeiguel V et al. Influence of the type of factor VIII concentrate on the incidence of factor VIII inhibitors in previously untreated patients with severe haemophilia A. Blood 2006; 107: 46-51.
    • (2006) Blood , vol.107 , pp. 46-51
    • Goudemand, J.1    Rothschild, C.2    Demeiguel, V.3
  • 19
    • 24944440876 scopus 로고    scopus 로고
    • Environmental risk factors for inhibitor development in children with haemophilia A: A case-control study
    • Santagostino E, Mancuso ME, Rocino A et al. Environmental risk factors for inhibitor development in children with haemophilia A: A case-control study. Br J Haematol 2005; 130: 422-7.
    • (2005) Br J Haematol , vol.130 , pp. 422-427
    • Santagostino, E.1    Mancuso, M.E.2    Rocino, A.3
  • 20
    • 0031057651 scopus 로고    scopus 로고
    • HLA class II profile: A weak determinant of factor VIII inhibitor development in severe haemophilia A
    • Hay CRM, Ollier W, Pepper L et al. HLA class II profile: A weak determinant of factor VIII inhibitor development in severe haemophilia A. Thromb Haemost 1997; 77: 234-7.
    • (1997) Thromb Haemost , vol.77 , pp. 234-237
    • Hay, C.R.M.1    Ollier, W.2    Pepper, L.3
  • 21
    • 0031045680 scopus 로고    scopus 로고
    • HLA genotype of patients with severe haemophilia A due to intron 22 inversion with and without inhibitors of factor VIII
    • Oldenburg J, Picard JK, Schwaab R, Brackmann HH, Tuddenham EGD, Simpson E. HLA genotype of patients with severe haemophilia A due to intron 22 inversion with and without inhibitors of factor VIII. Thromb Haemost 1997; 77: 238-42.
    • (1997) Thromb Haemost , vol.77 , pp. 238-242
    • Oldenburg, J.1    Picard, J.K.2    Schwaab, R.3    Brackmann, H.H.4    Tuddenham, E.G.D.5    Simpson, E.6
  • 22
    • 33645751563 scopus 로고    scopus 로고
    • Polymorphisms in the IL10 but not the IL-1 β and IL-4 genes are associated with inhibitor development in patients with haemophilia A
    • MIBS Study Group
    • Astermark J, Oldenburg J, Pavlova A, Berntorp E, Lefvert A-K, the MIBS Study Group. Polymorphisms in the IL10 but not the IL-1 β and IL-4 genes are associated with inhibitor development in patients with haemophilia A. Blood 2006; 107: 3167-72.
    • (2006) Blood , vol.107 , pp. 3167-3172
    • Astermark, J.1    Oldenburg, J.2    Pavlova, A.3    Berntorp, E.4    Lefvert, A.-K.5
  • 23
    • 0033832945 scopus 로고    scopus 로고
    • Oral immune tolerance induction to factor VIII via breast milk, a possibility
    • Yee TT, Lee CA. Oral immune tolerance induction to factor VIII via breast milk, a possibility ? Haemophilia 2000; 6: 591.
    • (2000) Haemophilia , vol.6 , pp. 591
    • Yee, T.T.1    Lee, C.A.2
  • 24
    • 0036735251 scopus 로고    scopus 로고
    • Breastfeeding does not influence the development of inhibitors in haemophilia
    • Knobe KE, Tengborn LI, Petrini P, Ljung RCR. Breastfeeding does not influence the development of inhibitors in haemophilia. Haemophilia 2002; 8: 657-9.
    • (2002) Haemophilia , vol.8 , pp. 657-659
    • Knobe, K.E.1    Tengborn, L.I.2    Petrini, P.3    Ljung, R.C.R.4
  • 25
    • 0034994489 scopus 로고    scopus 로고
    • Incidence of factor VIII inhibitors in severe haemophilia: The importance of patient age
    • Lorenzo JI, Lopez A, Altisent C, Aznar JA. Incidence of factor VIII inhibitors in severe haemophilia: The importance of patient age. Br J Haematol 2001; 113: 600-3.
    • (2001) Br J Haematol , vol.113 , pp. 600-603
    • Lorenzo, J.I.1    Lopez, A.2    Altisent, C.3    Aznar, J.A.4
  • 27
    • 0842333021 scopus 로고    scopus 로고
    • Intensive exposure to factor VIII is a risk factor for inhibitor development in mild haemophilia A
    • Sharathkumar A, Lillicrap D, Blanchette VS et al. Intensive exposure to factor VIII is a risk factor for inhibitor development in mild haemophilia A. J Thromb Haemost 2003; 1: 1228-36.
    • (2003) J Thromb Haemost , vol.1 , pp. 1228-1236
    • Sharathkumar, A.1    Lillicrap, D.2    Blanchette, V.S.3
  • 28
    • 25444445056 scopus 로고    scopus 로고
    • Inhibitor development in patients with hemophilia A after continuous infusion of factor VIII concentrates
    • Von Auer C, Oldenburg J, Von Depka M et al. Inhibitor development in patients with hemophilia A after continuous infusion of factor VIII concentrates. Ann NY Acad Sci 2005; 1051: 498-505.
    • (2005) Ann NY Acad Sci , vol.1051 , pp. 498-505
    • Von Auer, C.1    Oldenburg, J.2    Von Depka, M.3
  • 29
    • 85112375132 scopus 로고    scopus 로고
    • Higher immune tolerance (IT) success rate with monoclonal FVIII (mFVIII) when compared to recombinant (rFVIII): An analysis of The North American Immune Tolerance Registry (NAITR)
    • DiMichele D, Kroner B. Higher immune tolerance (IT) success rate with monoclonal FVIII (mFVIII) when compared to recombinant (rFVIII): An analysis of The North American Immune Tolerance Registry (NAITR). Blood 2000; 96: 266a.
    • (2000) Blood , vol.96
    • DiMichele, D.1    Kroner, B.2
  • 30
    • 0036282373 scopus 로고    scopus 로고
    • Inhibitor development in previously untreated patients with hemophilia A: A prospective long-term follow-up comparing plasma-derived and recombinant products
    • Kreuz W, Ettinghausen CE, Zyschka A et al. Inhibitor development in previously untreated patients with hemophilia A: A prospective long-term follow-up comparing plasma-derived and recombinant products. Semin Thromb Hemost 2002; 28: 285-90.
    • (2002) Semin Thromb Hemost , vol.28 , pp. 285-290
    • Kreuz, W.1    Ettinghausen, C.E.2    Zyschka, A.3
  • 31
    • 0031773630 scopus 로고    scopus 로고
    • French previously untreated patients with severe hemophilia A after exposure to recombinant factor VIII: Incidence of inhibitor and evaluation of immune tolerance
    • Rothschild C, Laurian Y, Satre EP et al. French previously untreated patients with severe hemophilia A after exposure to recombinant factor VIII: Incidence of inhibitor and evaluation of immune tolerance. Thromb Haemost 1998; 80: 779-83.
    • (1998) Thromb Haemost , vol.80 , pp. 779-783
    • Rothschild, C.1    Laurian, Y.2    Satre, E.P.3
  • 32
    • 0038383605 scopus 로고    scopus 로고
    • The epidemiology of inhibitors in haemophilia A: A systematic review
    • Wight J, Paisley S. The epidemiology of inhibitors in haemophilia A: A systematic review. Haemophilia 2003; 9: 418-35.
    • (2003) Haemophilia , vol.9 , pp. 418-435
    • Wight, J.1    Paisley, S.2
  • 33
    • 0023152347 scopus 로고
    • Incidence of inhibitors in patients with severe and moderate hemophilia A treated with factor VIII concentrates
    • Schwarzinger I, Pabinger I, Korninger C et al. Incidence of inhibitors in patients with severe and moderate hemophilia A treated with factor VIII concentrates. Am J Haematol 1987; 24: 241-5.
    • (1987) Am J Haematol , vol.24 , pp. 241-245
    • Schwarzinger, I.1    Pabinger, I.2    Korninger, C.3
  • 34
    • 0025187106 scopus 로고
    • Haemophiliacs with factor VIII inhibitors in Finland: Prevalence, incidence and outcome
    • Rasi V, Ikkala E. Haemophiliacs with factor VIII inhibitors in Finland: prevalence, incidence and outcome. Br J Haematol 1990; 76: 369-71.
    • (1990) Br J Haematol , vol.76 , pp. 369-371
    • Rasi, V.1    Ikkala, E.2
  • 35
    • 0027292869 scopus 로고
    • Incidence of inhibitor development in a group of young hemophilia A patients treated exclusively with lyophylised cryoprecipitate
    • Peerlinck K, Rosendaal FR, Vermylen J. Incidence of inhibitor development in a group of young hemophilia A patients treated exclusively with lyophylised cryoprecipitate. Blood 1993; 81: 3332-5.
    • (1993) Blood , vol.81 , pp. 3332-3335
    • Peerlinck, K.1    Rosendaal, F.R.2    Vermylen, J.3
  • 36
    • 0028858978 scopus 로고
    • Incidence of factor VIII inhibitor development in severe hemophilia A patients treated only with one brand of highly purified plasma-derived concentrate
    • Guerois C, Laurian Y, Rothschild C et al. Incidence of factor VIII inhibitor development in severe hemophilia A patients treated only with one brand of highly purified plasma-derived concentrate. Thromb Haemost 1995; 73: 215-8.
    • (1995) Thromb Haemost , vol.73 , pp. 215-218
    • Guerois, C.1    Laurian, Y.2    Rothschild, C.3
  • 37
    • 33751008597 scopus 로고
    • Zero incidence of inhibitors in previously untreated patients who received intermediate purity factor VIII concentrate or factor IX complex
    • Schimpf K, Schwarz P, Hunschak M. Zero incidence of inhibitors in previously untreated patients who received intermediate purity factor VIII concentrate or factor IX complex. Thromb Haemost 1995; 73: 997.
    • (1995) Thromb Haemost , vol.73 , pp. 997
    • Schimpf, K.1    Schwarz, P.2    Hunschak, M.3
  • 38
    • 0030779948 scopus 로고    scopus 로고
    • Absence of inhibitors in previously untreated patients with severe haemophilia A after exposure to a single intermediate purity factor VIII product
    • Yee TT, Williams MD, Hill FGH, Lee CA, Pasi KJ. Absence of inhibitors in previously untreated patients with severe haemophilia A after exposure to a single intermediate purity factor VIII product. Thromb Haemost 1997; 78: 1027.
    • (1997) Thromb Haemost , vol.78 , pp. 1027
    • Yee, T.T.1    Williams, M.D.2    Hill, F.G.H.3    Lee, C.A.4    Pasi, K.J.5
  • 39
    • 15344351616 scopus 로고    scopus 로고
    • Full length sucrose formulated recombinant factor VIII for treatment of previously untreated or minimally treated young children with severe haemophilia A: Results of an international clinical investigation
    • Kreuz W, Gill JC, Rothschild C et al. Full length sucrose formulated recombinant factor VIII for treatment of previously untreated or minimally treated young children with severe haemophilia A: Results of an international clinical investigation. Thromb Haemost 2005; 93: 457-67.
    • (2005) Thromb Haemost , vol.93 , pp. 457-467
    • Kreuz, W.1    Gill, J.C.2    Rothschild, C.3


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