Oral immune tolerance induction to factor VIII via breast milk, a possibility?

Haemophilia

Volumn 6, Issue 5, 2000, Pages 591-

  Yee, T T ^a   Lee, C A ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 8 CONCENTRATE; BLOOD CLOTTING FACTOR 8 INHIBITOR; BREAST MILK; CYTOKINE; FAS ANTIGEN; FAS LIGAND; FAT; GLYCOPROTEIN; INTERLEUKIN 10; INTERLEUKIN 4; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; BREAST FEEDING; CHILD; CONTROLLED STUDY; DISEASE SEVERITY; GENE DELETION; HEMOPHILIA A; HUMAN; HYPOTHESIS; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; INCIDENCE; LETTER; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; UNITED KINGDOM;

ADMINISTRATION, ORAL; ANIMAL; BREAST FEEDING; FACTOR VIII; GREAT BRITAIN; HEMOPHILIA A; HUMAN; IMMUNE TOLERANCE; MILK, HUMAN;

EID: 0033832945     PISSN: 13518216     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2516.2000.00451.x     Document Type: Letter

References (9)

1. A Breast feeding provides passive and likely long-lasting active immunity
2. Studies on the chemistry of anaphylaxis. 111. Experiments with isolated proteins, especially those of hen's egg
3. Soluble Fas and soluble Fas ligand proteins in human milk: Possible significance in the development of immunological tolerance
4. A M(r) 46,000 human milk fat globule protein that is highly expressed in human breast tumors contains factor VIII-like domains
5. Some factor VIII inhibitor antibodies recognise a common epitope corresponding to C2 domain amino acids 2248-2312 which overlap a phospholipid binding site
6. Oral tolerance induction to the development of human factor VIII antibodies in neonatal BALB/C mice
7. Oral immune tolerance induction with factor VIII concentrate in three patients with acquired haemophilia A
8. Nutrition and Dietary Advice in the Pharmacy
9. Factor VIII inhibitors in haemophiliacs: A single centre experience over 34 years 1964-97