메뉴 건너뛰기




Volumn 3, Issue 3, 2006, Pages 261-267

Targeting transcription factors in cancer: Challenges and evolving strategies

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS AFFECTING WATER, MOLECULE OR ION TRANSPORT; ANTIFUNGAL AGENT; ANTISENSE OLIGONUCLEOTIDE; AVI 4126; BETA CATENIN; CAND 5; DECOY OLIGONUCLEOTIDE; DENDRIMER; G QUARTET OLIGONUCLEOTIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; LIPOSOME; MICROBICIDE; MYC PROTEIN; OLIGONUCLEOTIDE; ONCOMYC NG; SHORT HAIRPIN RNA; SIRNA 027; SMALL MOLECULE INHIBITOR; STAT3 PROTEIN; STAT5 PROTEIN; STEROID RECEPTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 33751003260     PISSN: 17406749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddtec.2006.09.010     Document Type: Review
Times cited : (20)

References (40)
  • 1
    • 8844262660 scopus 로고    scopus 로고
    • Principles for modulation of the nuclear receptor superfamily
    • Gronemeyer H., et al. Principles for modulation of the nuclear receptor superfamily. Nat. Rev. Drug Discov. 3 (2004) 950-964
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 950-964
    • Gronemeyer, H.1
  • 2
    • 0034722896 scopus 로고    scopus 로고
    • STAT proteins: novel molecular targets for cancer drug discovery
    • Turkson J., and Jove R. STAT proteins: novel molecular targets for cancer drug discovery. Oncogene 19 (2000) 6613-6626
    • (2000) Oncogene , vol.19 , pp. 6613-6626
    • Turkson, J.1    Jove, R.2
  • 3
    • 0037112367 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells
    • Mora L.B., et al. Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. Cancer Res. 62 (2002) 6659-6666
    • (2002) Cancer Res. , vol.62 , pp. 6659-6666
    • Mora, L.B.1
  • 4
    • 0033529704 scopus 로고    scopus 로고
    • Stat3 as an oncogene
    • Bromberg J.F., et al. Stat3 as an oncogene. Cell 98 (1999) 295-303
    • (1999) Cell , vol.98 , pp. 295-303
    • Bromberg, J.F.1
  • 5
    • 28644445445 scopus 로고    scopus 로고
    • Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
    • Kortylewski M., et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat. Med. 11 (2005) 1314-1321
    • (2005) Nat. Med. , vol.11 , pp. 1314-1321
    • Kortylewski, M.1
  • 6
    • 12944272024 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
    • Grandis J.R., et al. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc. Natl. Acad. Sci. U S A 97 (2000) 4227-4232
    • (2000) Proc. Natl. Acad. Sci. U S A , vol.97 , pp. 4227-4232
    • Grandis, J.R.1
  • 7
    • 33644983005 scopus 로고    scopus 로고
    • Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer
    • Jing N., et al. Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer. Mol. Cancer Ther. 5 (2006) 279-286
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 279-286
    • Jing, N.1
  • 8
    • 0142219889 scopus 로고    scopus 로고
    • Constitutive activation of Stat5b contributes to carcinogenesis in vivo
    • Xi S., et al. Constitutive activation of Stat5b contributes to carcinogenesis in vivo. Cancer Res. 63 (2003) 6763-6771
    • (2003) Cancer Res. , vol.63 , pp. 6763-6771
    • Xi, S.1
  • 9
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-κB in cancer development and progression
    • Karin M. Nuclear factor-κB in cancer development and progression. Nature 441 (2006) 431-436
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 10
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. 3 (2003) 721-732
    • (2003) Nat. Rev. , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 11
    • 19944403876 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling pathway as novel cancer drug targets
    • Luu H.H., et al. Wnt/β-catenin signaling pathway as novel cancer drug targets. Curr. Cancer Drug Targets 4 (2004) 653-671
    • (2004) Curr. Cancer Drug Targets , vol.4 , pp. 653-671
    • Luu, H.H.1
  • 12
    • 27544456436 scopus 로고    scopus 로고
    • Cancer therapeutics: targeting the dark side of Myc
    • Ponzielli R., et al. Cancer therapeutics: targeting the dark side of Myc. Eur. J. Cancer 41 (2005) 2485-2501
    • (2005) Eur. J. Cancer , vol.41 , pp. 2485-2501
    • Ponzielli, R.1
  • 13
    • 0037479844 scopus 로고    scopus 로고
    • Efficacy of antisense morpholino oligomer target to c-myc in prostate cancer xenograft murine model and a Phase I safety study in humans
    • Iversen P.L., et al. Efficacy of antisense morpholino oligomer target to c-myc in prostate cancer xenograft murine model and a Phase I safety study in humans. Clin. Cancer Res. 9 (2003) 2510-2519
    • (2003) Clin. Cancer Res. , vol.9 , pp. 2510-2519
    • Iversen, P.L.1
  • 14
    • 0037444373 scopus 로고    scopus 로고
    • Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
    • Blaskovich M.A., et al. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 63 (2003) 1270-1279
    • (2003) Cancer Res. , vol.63 , pp. 1270-1279
    • Blaskovich, M.A.1
  • 15
    • 4644325545 scopus 로고    scopus 로고
    • G-quartet oligonucleotides: a new class of Stat3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis
    • Jing N., et al. G-quartet oligonucleotides: a new class of Stat3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis. Cancer Res. 64 (2004) 6603-6609
    • (2004) Cancer Res. , vol.64 , pp. 6603-6609
    • Jing, N.1
  • 16
    • 28844454167 scopus 로고    scopus 로고
    • Antisense strategies for oncogene inactivation
    • Stein C.A., et al. Antisense strategies for oncogene inactivation. Semin. Oncol. 32 (2005) 563-572
    • (2005) Semin. Oncol. , vol.32 , pp. 563-572
    • Stein, C.A.1
  • 17
    • 4844225667 scopus 로고    scopus 로고
    • Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics
    • Arora V., et al. Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics. Curr. Pharm. Biotechnol. 5 (2004) 431-439
    • (2004) Curr. Pharm. Biotechnol. , vol.5 , pp. 431-439
    • Arora, V.1
  • 18
    • 33645148088 scopus 로고    scopus 로고
    • The silent treatment: siRNAs as small molecule drugs
    • Dykxhoorn D.M., et al. The silent treatment: siRNAs as small molecule drugs. Gene Ther. 13 (2006) 541-552
    • (2006) Gene Ther. , vol.13 , pp. 541-552
    • Dykxhoorn, D.M.1
  • 19
    • 14544300545 scopus 로고    scopus 로고
    • Tumour-selective drug delivery via folate receptor-targeted liposomes
    • Pan X., and Lee R.J. Tumour-selective drug delivery via folate receptor-targeted liposomes. Expert Opin. Drug Deliv. 1 (2004) 7-17
    • (2004) Expert Opin. Drug Deliv. , vol.1 , pp. 7-17
    • Pan, X.1    Lee, R.J.2
  • 20
    • 32544452539 scopus 로고    scopus 로고
    • Immunoliposomes for cancer therapy
    • Kontermann R.E. Immunoliposomes for cancer therapy. Curr. Opin. Mol. Ther. 8 (2006) 39-45
    • (2006) Curr. Opin. Mol. Ther. , vol.8 , pp. 39-45
    • Kontermann, R.E.1
  • 21
    • 22244459917 scopus 로고    scopus 로고
    • Gene therapy: twenty-first century medicine
    • Verma I.M., and Weitzman M.D. Gene therapy: twenty-first century medicine. Annu. Rev. Biochem. 74 (2005) 711-738
    • (2005) Annu. Rev. Biochem. , vol.74 , pp. 711-738
    • Verma, I.M.1    Weitzman, M.D.2
  • 22
    • 0142084745 scopus 로고    scopus 로고
    • 2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
    • 2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302 (2003) 415-419
    • (2003) Science , vol.302 , pp. 415-419
    • Hacien-Bey-Abina, S.1
  • 23
    • 28744440082 scopus 로고    scopus 로고
    • Dendrimers in gene delivery
    • Dufes C., et al. Dendrimers in gene delivery. Adv. Drug Deliv. Rev. 57 (2005) 2177-2202
    • (2005) Adv. Drug Deliv. Rev. , vol.57 , pp. 2177-2202
    • Dufes, C.1
  • 24
    • 14544298301 scopus 로고    scopus 로고
    • Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle
    • Schiffelers R.M., et al. Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic Acids Res. 32 (2004) e149
    • (2004) Nucleic Acids Res. , vol.32
    • Schiffelers, R.M.1
  • 25
    • 20944435271 scopus 로고    scopus 로고
    • Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target
    • Chiarle R., et al. Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target. Nat. Med. 11 (2005) 623-629
    • (2005) Nat. Med. , vol.11 , pp. 623-629
    • Chiarle, R.1
  • 26
    • 13944250650 scopus 로고    scopus 로고
    • In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy
    • Xi S., et al. In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy. Oncogene 24 (2005) 970-979
    • (2005) Oncogene , vol.24 , pp. 970-979
    • Xi, S.1
  • 27
    • 7444238184 scopus 로고    scopus 로고
    • Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines
    • Barton B.E., et al. Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines. Mol. Cancer Ther. 3 (2004) 1183-1191
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 1183-1191
    • Barton, B.E.1
  • 28
    • 24344455107 scopus 로고    scopus 로고
    • Down-regulation of signal transducer and activator of transcription 3 expression using vector-based small interfering RNAs suppresses growth of human prostate tumor in vivo
    • Gao L., et al. Down-regulation of signal transducer and activator of transcription 3 expression using vector-based small interfering RNAs suppresses growth of human prostate tumor in vivo. Clin. Cancer Res. 11 (2005) 6333-6341
    • (2005) Clin. Cancer Res. , vol.11 , pp. 6333-6341
    • Gao, L.1
  • 29
    • 2542449068 scopus 로고    scopus 로고
    • Enhanced chemosensitivity to irinotecan by RNA interference-mediated down-regulation of the nuclear factor-κB p65 subunit
    • Guo J., et al. Enhanced chemosensitivity to irinotecan by RNA interference-mediated down-regulation of the nuclear factor-κB p65 subunit. Clin. Cancer Res. 10 (2004) 3333-3341
    • (2004) Clin. Cancer Res. , vol.10 , pp. 3333-3341
    • Guo, J.1
  • 30
    • 27644518437 scopus 로고    scopus 로고
    • YC-1 suppresses constitutive nuclear factor-κB activation and induces apoptosis in human prostate cancer cells
    • Huang Y.-T., et al. YC-1 suppresses constitutive nuclear factor-κB activation and induces apoptosis in human prostate cancer cells. Mol. Cancer Ther. 4 (2005) 1628-1635
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 1628-1635
    • Huang, Y.-T.1
  • 31
    • 12944273470 scopus 로고    scopus 로고
    • Targeting of nuclear factor κB pathways by dehydroxymethylepoxyquinomicin, a novel inhibitor of breast carcinomas: antitumor and antiangiogenic potential in vivo
    • Matsumoto G., et al. Targeting of nuclear factor κB pathways by dehydroxymethylepoxyquinomicin, a novel inhibitor of breast carcinomas: antitumor and antiangiogenic potential in vivo. Clin. Cancer Res. 11 (2005) 1287-1293
    • (2005) Clin. Cancer Res. , vol.11 , pp. 1287-1293
    • Matsumoto, G.1
  • 32
    • 3142767508 scopus 로고    scopus 로고
    • Anticancer agent CHS 828 suppresses nuclear factor-κB activity in cancer cells through downregulation of IKK activity
    • Olsen L.S., et al. Anticancer agent CHS 828 suppresses nuclear factor-κB activity in cancer cells through downregulation of IKK activity. Int. J. Cancer 111 (2004) 198-205
    • (2004) Int. J. Cancer , vol.111 , pp. 198-205
    • Olsen, L.S.1
  • 33
    • 0037414180 scopus 로고    scopus 로고
    • YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1
    • Yeo E.-J., et al. YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J. Natl. Cancer Inst. 95 (2003) 516-525
    • (2003) J. Natl. Cancer Inst. , vol.95 , pp. 516-525
    • Yeo, E.-J.1
  • 34
    • 0035003528 scopus 로고    scopus 로고
    • Gene transfer of antisense hypoxia inducible factor-1α enhances the therapeutic efficacy of cancer immunotherapy
    • Sun X., et al. Gene transfer of antisense hypoxia inducible factor-1α enhances the therapeutic efficacy of cancer immunotherapy. Gene Ther. 8 (2001) 638-645
    • (2001) Gene Ther. , vol.8 , pp. 638-645
    • Sun, X.1
  • 35
    • 0035420212 scopus 로고    scopus 로고
    • Suppression of β-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells
    • Roh H., et al. Suppression of β-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells. Cancer Res. 61 (2001) 6563-6568
    • (2001) Cancer Res. , vol.61 , pp. 6563-6568
    • Roh, H.1
  • 36
    • 0037388638 scopus 로고    scopus 로고
    • Small interfering RNAs directed against β-catenin inhibit the in vitro and in vivo growth of colon cancer cells
    • Verma U.N., et al. Small interfering RNAs directed against β-catenin inhibit the in vitro and in vivo growth of colon cancer cells. Clin. Cancer Res. 9 (2003) 1291-1300
    • (2003) Clin. Cancer Res. , vol.9 , pp. 1291-1300
    • Verma, U.N.1
  • 37
    • 4344587136 scopus 로고    scopus 로고
    • A small molecule inhibitor of β-catenin/CREB-binding protein transcription
    • Emami K.H., et al. A small molecule inhibitor of β-catenin/CREB-binding protein transcription. Proc. Natl. Acad. Sci. U S A 101 (2004) 12682-12687
    • (2004) Proc. Natl. Acad. Sci. U S A , vol.101 , pp. 12682-12687
    • Emami, K.H.1
  • 38
    • 0034881060 scopus 로고    scopus 로고
    • Encapsulation of c-myc antisense oligodeoxynucleotides in lipid particles improves antitumoral efficacy in vivo in a human melanoma line
    • Leonetti C., et al. Encapsulation of c-myc antisense oligodeoxynucleotides in lipid particles improves antitumoral efficacy in vivo in a human melanoma line. Cancer Gene Ther. 8 (2001) 459-468
    • (2001) Cancer Gene Ther. , vol.8 , pp. 459-468
    • Leonetti, C.1
  • 39
    • 10744233586 scopus 로고    scopus 로고
    • Targeted liposomal c-myc antisense oligodeoxynucleotides induce apoptosis and inhibit tumor growth and metastases in human melanoma models
    • Pastorino F., et al. Targeted liposomal c-myc antisense oligodeoxynucleotides induce apoptosis and inhibit tumor growth and metastases in human melanoma models. Clin. Cancer Res. 9 (2003) 4595-4605
    • (2003) Clin. Cancer Res. , vol.9 , pp. 4595-4605
    • Pastorino, F.1
  • 40
    • 3142781225 scopus 로고    scopus 로고
    • Small-molecule inhibitors of protein-protein interactions: progressing towards the dream
    • Arkin M.R., and Wells J.A. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat. Rev. Drug Discov. 3 (2004) 301-317
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 301-317
    • Arkin, M.R.1    Wells, J.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.