Zolpidem, a selective GABAA receptor α1 subunit agonist, induces comparable Fos expression in oxytocinergic neurons of the hypothalamic paraventricular and accessory but not supraoptic nuclei in the rat

Brain Research Bulletin

Volumn 71, Issue 1-3, 2006, Pages 200-207

  Kiss, Alexander ^a   Søderman, Andreas ^b   Bundzikova, Jana ^a   Pirnik, Zdeno ^a   Mikkelsen, Jens D ^b  

^a INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY   (Slovakia)

^b NEUROSEARCH A S   (Denmark)

Author keywords

Dual immunohistochemistry; Fos; Hypothalamic accessory cells; Oxytocin; PVN; Rat; SON; Zolpidem

Indexed keywords

ANIMALS; BIOLOGICAL MARKERS; GABA AGONISTS; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAPERITONEAL; MALE; NEURONS; OXYTOCIN; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PROTO-ONCOGENE PROTEINS C-FOS; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, GABA-A; SUPRAOPTIC NUCLEUS;

EID: 33750980981     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2006.09.004     Document Type: Article

References (51)

1. Argiolas A. Neuropeptides and sexual behaviour. Neurosci. Biobehav. Rev. 23 (1999) 1127-1142
2. Blanks A.M., and Thornton S. The role of oxytocin in parturition. BJOG 110 (2003) 46-51
3. Bondy C.A., Whitnall M.H., Brady L.S., and Gainer H. Coexisting peptides in hypothalamic neuroendocrine systems: some functional implications. Cell. Mol. Neurobiol. 9 (1989) 427-446
4. Brailoiu G.C., Dun S.L., Yang J., Ohsawa M., Chang J.K., and Dun N.J. Apelin-immunoreactivity in the rat hypothalamus and pituitary. Neurosci. Lett. 327 (2002) 193-197
5. Briski K.P., and Brandt J.A. Oxytocin and vasopressin neurones in principal and accessory hypothalamic magnocellular structures express Fos-immunoreactivity in response to acute glucose deprivation. J. Neuroendocrinol. 12 (2000) 409-414
6. Burbach J.P., Voorhuis T.A., van Tol H.H., and Ivell R. In situ hybridization of Oxytocin messenger RNA: macroscopic distribution and quantitation in rat hypothalamic cell groups. Biochem. Biophys. Res. Commun. 145 (1987) 10-14
7. Carter C.S. Oxytocin and sexual behaviour. Neurosci. Biobehav. Rev. 16 (1992) 131-144
8. Ding J.M., Carver W.C., Terracio L., and Buggy J. Proto-oncogene c-fos and the regulation of vasopressin gene expression during dehydration. Brain Res. Mol. Brain Res. 21 (1994) 247-255
9. Duan X.Q., and Ju G. The organization of chemically characterized afferents to the Perivascular neuronal groups of the hypothalamic magnocellular neurosecretory system in the rat. Brain Res. Bull. 46 (1998) 409-415
10. Eriksson M., Ceccatelli S., Uvnas-Moberg K., Iadarola M., and Hokfelt T. Expression of Fos-related antigens, oxytocin, dynorphin and galanin in the paraventricular and supraoptic nuclei of lactating rats. Neuroendocrinology 63 (1996) 356-367
11. Fahey J.M., Grassi J.M., Reddi J.M., and Greenblatt D.J. Acute zolpidem administration produces pharmacodynamic and receptor occupancy changes at similar doses. Pharmacol. Biochem. Behav. 83 (2006) 21-27
12. Farina-Lipari E., and Valentino B. Immunohistochemical research on vasopressin in the accessory hypothalamic nuclei. Ital. J. Anat. Embryol. 98 (1993) 207-214
13. Farina-Lipari E., Valentino B., and Lipari D. Immunohistochemical research on oxytocin in the hypothalamic accessory nuclei. Ital. J. Anat. Embryol. 100 (1995) 189-193
14. Giovannelli L., Shiromani P.J., Jirikowski G.F., and Bloom F.E. Oxytocin neurons in the rat hypothalamus exhibit c-fos immunoreactivity upon osmotic stress. Brain Res. 531 (1990) 299-303
15. Giovannelli L., Shiromani P.J., Jirikowski G.F., and Bloom F.E. Expression of c-fos protein by immunohistochemically identified oxytocin neurons in the rat hypothalamus upon osmotic stimulation. Brain Res. 588 (1992) 41-48
16. Hatton G.I. Nucleus circularis: is it an osmoreceptor in the brain?. Brain Res. Bull. 1 (1976) 123-131
17. Hou-Yu A., Lamme A.T., Zimmerman E.A., and Silverman A.J. Comparative distribution of vasopressin and oxytocin neurons in the rat brain using a double-label procedure. Neuroendocrinology 44 (1986) 235-246
18. Huang R.Q., and Dillon G.H. Functional characterization of GABA(A) receptors in neonatal hypothalamic brain slice. J. Neurophysiol. 88 (2002) 1655-1663
19. Jirikowski G.F., Back H., Forssmann W.G., and Stumpf W.E. Coexistence of atrial natriuretic factor (ANF) and oxytocin in neurons of the rat hypothalamus. Neuropeptides 8 (1986) 243-249
20. Jirikowski G.F., Ramalho-Ortigao F.J., and Caldwell J.D. Transitory coexistence of oxytocin and vasopressin in the hypothalamo neurohypophysial system of parturient rats. Horm. Metab. Res. 23 (1991) 476-480
21. Ju G., Liu S., and Tao J. Projections from the hypothalamus and its adjacent areas to the posterior pituitary in the rat. Neuroscience 19 (1986) 803-828
22. Kiss J.Z., Martos J., and Palkovits M. Hypothalamic paraventricular nucleus: a quantitative analysis of cytoarchitectonic subdivisions in the rat. J. Comp. Neurol. 313 (1991) 563-573
23. Kiss A., and Mikkelsen J.D. Oxytocin-anatomy and functional assignments: a minireview. Endocr. Regul. 39 (2005) 97-105
24. Landry M., Trembleau A., Arai R., and Calas A. Evidence for a colocalization of oxytocin mRNA and galanin in magnocellular hypothalamic neurons: a study combining in situ hybridization and immunohistochemistry. Brain Res. Mol. Brain Res. 10 (1991) 91-95
25. Larsen P.J., Mikkelsen J.D., Jessop D.S., Lightman S.L., and Chowdrey H.S. NeuropeptideY mRNA and immunoreactivity in hypothalamic neuroendocrine neurons: effects of adrenalectomy and chronic osmotic stimulation. J. Neurosci. 13 (1993) 1138-1147
26. Larsen P.J., Hay-Schmidt A., and Mikkelsen J.D. Efferent connections from the lateral hypothalamic region and the lateral preoptic area to the hypothalamic paraventricular nucleus of the rat. J. Comp. Neurol. 342 (1994) 299-319
27. Makarenko I.G., Ugrumov M.V., Derer P., and Calas A. Projections from the hypothalamus to the posterior lobe in rats during ontogenesis: 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate tracing study. J. Comp. Neurol. 422 (2000) 327-337
28. Mikkelsen J.D., Vrang N., and Mrosovsky N. Expression of Fos in the circadian system following nonphotic stimulation. Brain Res. Bull. 47 (1998) 367-376
29. Mikkelsen J.D., Soderman A., Kiss A., and Mirza N. Effects of benzodiazepines receptor agonists on the hypothalamic-pituitary-adrenocortical axis. Eur. J. Pharmacol. 519 (2005) 223-230
30. Mirza N.R., Rodgers R.J., and Mathiasen L.S. Comparative cue generalization profiles of L-838 417 SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, zopiclone, and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination. J. Pharmacol. Exp. Ther. 316 (2006) 1291-1299
31. Miselis R.R. The efferent projections of the subfornical organ of the rat: a circumventricular organ within a neural network subserving water balance. Brain Res. 28 (1981) 1-23
32. Neumann I., Douglas A.J., Pittman Q.J., Russell J.A., and Landgraf R. Oxytocin released within the supraoptic nucleus of the rat brain by positive feedback action is involved in parturition-related events. J. Neuroendocrinol. 8 (1996) 227-233
33. Ng Y.K., Brailoiu G.C., Dun S.L., Ling E.A., Yang J., Chang J.K., and Dun N.J. Beacon immunoreactivity in the rat hypothalamus. J. Neurosci. Res. 83 (2006) 1106-1117
34. Peterson R.P. Magnocellular neurosecretory centers in the rat hypothalamus. J. Comp. Neurol. 128 (1966) 181-190
35. Pirnik Z., Mravec B., and Kiss A. Fos protein expression in mouse hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei upon osmotic stimulus: colocalization with vasopressin, oxytocin, and tyrosine hydroxylase. Neurochem. Int. 45 (2004) 597-607
36. Pirnik Z., Jezova D., Mikkelsen J.D., and Kiss A. Xylazine activates oxytocinergic but not vasopressinergic hypothalamic neurons under normal and hyperosmotic conditions in rats. Neurochem. Int. 47 (2005) 458-465
37. Pretel S., and Piekut D.T. Coexistence of CRF peptide and oxytocin mRNA in the paraventricular nucleus. Peptides 11 (1990) 621-624
38. Reaves T.A., and Hayward Jr. J.N. Immunocytochemical identification of vasopressinergic and oxytocinergic neurons in the hypothalamus of the cat. Cell Tissue Res. 196 (1979) 117-122
39. Riva C., Eggli P., Felix D., Mosimann R., and Imboden H. Hypothalamic accessory nuclei and their relation to the angiotensinergic and vasopressinergic systems. Regul. Pept. 83 (1999) 129-133
40. Rudolph U., Crestani F., and Mohler H. GABA(A) receptor subtypes: dissecting their pharmacological functions. Trends Pharmacol. Sci. 22 (2001) 188-194
41. Sanchez F., Alonso J.R., Arevalo R., Blanco E., Aijon J., and Vazquez R. Coexistence of NADPH-diaphorase with vasopressin and oxytocin in the hypothalamic magnocellular neurosecretory nuclei of the rat. Cell Tissue Res. 276 (1994) 31-34
42. Shen E., Dun S.L., Ren C., and Dun N.J. Hypovolemia induces Fos-like immunoreactivity in neurons of the rat supraoptic and paraventricular nuclei. J. Auton. Nerv. Syst. 37 (1992) 227-230
43. Skutella T., Weber T., and Jirkowski G.F. Coexistence of oxytocin and tyrosine hydroxylase in the rat hypothalamus, an immunocytochemical study. J. Neural. Transm. Gen. Sect. 94 (1993) 55-61
44. Suemaru S., Hashimoto K., Ogasa T., Takao T., Ota Z., Hirakawa M., and Kawata M. Effects of hyperosmotic stimulation and adrenalectomy on vasopressin mRNA levels in the paraventricular and supraoptic nuclei of the hypothalamus: in situ hybridization histochemical analysis using a synthetic oligonucleotide probe. Acta Med. Okayama 44 (1990) 233-241
45. Swanson L.W., and Kuypers H.G.J.M. The paraventricular nucleus of the hypothalamus: cytoarchitectonic subdivisions and organization of projections to the pituitary, dorsal vagal complex and spinal cord as demonstrated by retrograde fluorescence double-labeling methods. J. Comp. Neurol. 194 (1980) 555-570
46. Telleria-Diaz A., Grinevich V.V., and Jirikowski G.F. Colocalization of vasopressin and oxytocin in hypothalamic magnocellular neurons in water-deprived rats. Neuropeptides 35 (2001) 162-167
47. Tsuruo Y., Ceccatelli S., Villar M.J., Hokfelt T., Visser T.J., Terenius L., Goldstein M., Brown J.C., Buchan A., and Walsh J. Coexistence of TRH with other neuroactive substances in the rat central nervous system. J. Chem. Neuroanat. 1 (1988) 235-253
48. Tweedle C.D., and Hatton G.I. Ultrastructural comparisons of neurons of supraoptic and circularis nuclei in normal and dehydrated rats. Brain Res. Bull. 1 (1976) 103-121
49. Woldbye D.P., Greisen M.H., Bolwig T.G., Larsen P.J., and Mikkelsen J.D. Prolonged induction of c-fos in neuropeptide Y- and somatostatin-immunoreactive neurons of the rat dentate gyrus after electroconvulsive stimulation. Brain Res. 720 (1996) 111-119
50. Xiao M., Ding J., Wu L., Han Q., Wang H., Zuo G., and Hu G. The distribution of neural nitric oxide synthase-positive cerebrospinal fluid-contacting neurons in the third ventricular wall of male rats and coexistence with vasopressin or oxytocin. Brain Res. 21 (2005) 150-162
51. Xiong J.J., and Hatton G.I. Differential responses of oxytocin and vasopressin neurons to the osmotic and stressful components of hypertonic saline injections: a Fos protein double labeling study. Brain Res. 719 (1996) 143-153