Oxytocin released within the supraoptic nucleus of the rat brain by positive feedback action is involved in parturition-related events

Journal of Neuroendocrinology

Volumn 8, Issue 3, 1996, Pages 227-233

  Neumann, Inga ^a   Douglas, Alison J ^b   Pittman, Quentin J ^c   Russell, John A ^b   Landgraf, Rainer ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

Birth; Lactation; Maternal behaviour; Microdialysis; Oxytocin antagonist; Oxytocin secretion

Indexed keywords

OXYTOCIN; OXYTOCIN ANTAGONIST; OXYTOCIN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CHILDBIRTH; CONTROLLED STUDY; FEMALE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; LACTATION; MICRODIALYSIS; NONHUMAN; OXYTOCIN BLOOD LEVEL; OXYTOCIN RELEASE; POSITIVE FEEDBACK; PRIORITY JOURNAL; RAT; SUCKLING; SUPRAOPTIC NUCLEUS;

EID: 0030000661     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.1996.04557.x     Document Type: Article

References (37)

1. Summerlee AJS. (1981). Extracellular recordings from oxytocin neurones during the expulsive phase of birth in unanaesthetized rats. J Physiol. 321: 1-9.
2. Wakerley JB, Lincoln DW. (1973). The milk ejection reflex of the rar a 20- to 40-fold acceleration in the firing of paraventricular neurons during oxytocin release. J Endocrinol. 57: 477-493.
3. Poulain DA, Wakerley JB. (1982). Electrophysiology of hypothalamic magnocellular neurones secreting oxytocin and vasopressin. Neuroscience. 7: 773-808.
4. Higuchi T, Tadokoro Y, Honda K, Negoro H. (1986). Detailed analysis of blood oxytocin levels during suckling and parturition in the rat. J Endocrinol. 110: 251-256.
5. Freund-Mercier M-J, Richard P. (1984). Electrophysiological evidence for facilitatory control of oxytocin neurones by oxytocin during suckling in the rat. J Physiol. 352: 447-464.
6. Moos F, Richard Ph, (1989). Paraventricular and supraoptic bursting oxytocin cells in rat are locally regulated by oxytocin and functionally related. J Physiol. 408: 1-18.
7. Moos F, Poulain DA, Rodriguez F, Guerné Y, Vincent J-D, Richard Ph. (1989). Release of oxytocin within the supraoptic nucleus during the milk ejection reflex in rats. Exp Brain Res. 76: 593-602.
8. Neumann I, Russell JA, Landgraf R. (1993). Oxytocin and vasopressin release within the supraoptic and paraventricular nuclei of pregnant, parturient and lactating rats: a microdialysis study. Neuroscience. 53: 65-75.
9. Lambert RC, Moos FC, Richard Ph. (1993). Action of endogenous oxytocin within the paraventricular or supraoptic nuclei: a powerful link in the regulation of the bursting pattern of oxytocin neurons during the milk-ejection reflex in rats. Neuroscience. 57: 1027-1038.
10. Neumann I, Koehler E, Landgraf R, Summy-Long J. (1994). An oxytocin receptor antagonist infused into the supraoptic nucleus attenuates intranuclear and peripheral release of oxytocin during suckling in conscious rats. Endocrinology. 134: 141-148.
11. Theodosis DT, Poulain DA. (1986). Evidence that oxytocin-secreting neurons are involved in the ultrastructural reorganization of the rat supraoptic nucleus apparent at lactation. Cell Tiss Res. 235: 217-219
12. Moos F, Ingram CD, Wakerley JB, Guerne Y, Freund-Mercier MJ, Richard Ph. (1991). Oxytocin in the bed nucleus of the stria terminalis and lateral septum facilitates bursting of hypothalamic oxytocin neurones in suckled rats. J Neuroendocrinol. 3: 163-171.
13. Van Leengoed E, Kerker K, Swanson HH. (1987). Inhibition of postpartum maternal behaviour in the rat by injecting an oxytocin antagonist into the cerebral ventricles. J Endocrinol. 112: 275-282.
14. Pedersen CA, Caldwell JD, Walker C Ayers G, Mason, GA. (1994). Oxytocin activates the postpartum onset of rat maternal behavior in the ventral tegmental and medial preoptic areas. Behav Neurosci. 108: 1163-1171.
15. Neumann I, Landgraf R, Takahashi Y, Pittman QJ. (1994). Positive feedback action of oxytocin released within the supraoptic nucleus during parturition. Can J Physiol Pharmacol. 24: 125.
16. Russell JA, Neumann I, Landgraf R, Douglas A. (1994). Central oxytocin and parturition in rats. Neuroendocrinology. 60: S1, P3.5.
17. Summy-Long, JY, Neumann I, Terrell ML, Koehler E, Gestl S, Landgraf R, Kadekaro M. (1994). Crosstalk in the magnocellular system during osmotic stimulation of one supraoptic nucleus. Brain Res Bull. 33: 645-654.
18. Neumann I, Landgraf R, Bauce L, Pittman QJ. (1995). Osmotic responsiveness and crosstalk involving oxytocin, but not vasopressin or amino acids between the supraoptic nuclei in virgin and lactating rats. J Neurosci. 15: 3408-3417.
19. Pow DV, Morris JF. (1989). Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis. Neuroscience. 32: 435-440.
20. Theodosis DT. (1985). Oxytocin-immunoreactive terminals synapse on oxytocin neurones in the supraoptic nucleus. Nature. 313: 682-684.
21. Meyer C, Freund-Mercier MJ, Guerné Y, Richard Ph. (1987). Relationship between oxytocin release and amplitude of oxytocin cell neurosecretory bursts during suckling m the rat. J Endocr. 114: 263-270.
22. Freund-Mercier M-J, Stoeckel M-E, Klein M-J. (1994). Oxytocin receptors on oxytocin neurones: histoautoradiographic detection in the lactating rat. J Physiol. 480: 155-161.
23. Yamashita H, Okuya S, Inenaga K, Kasai M, Uesugi S, Kannan H, Kaneko T. (1987). Oxytocin predominantly excites putative oxytocin neurons in the rat supraoptic nucleus in vitro. Brain Res. 416: 364-367.
24. 2+ concentration of isolated rat supraoptic cells in response to oxytocin. J Physiol. 478: 275-288, 1994.
25. Kawarabayashi T, Kuriyama K, Nakashima T, Kiyohara T, Sugimori H. (1992). Oxytocin modulates oxytocin neurons in the paraventricular nuclei of female rats throughout pregnancy and parturition. Am J Obstet Gynecol. 168: 969-973.
26. Wang H, Ward AR, Morris JF. (1995). Oestradiol acutely stimulates exocytosis of oxytocin and vasopressin from dendrites and somata of hypothalamic magnocellular neurons. Neuroscience. 68: 1179-1188.
27. Luckman SM, Antonijevic I, Leng G, Dye S, Douglas AJ, Russell JA, Bicknell RJ (1993). The maintenance of normal parturition in the rat requires neurohypophysial oxytocin. J Neuroendocrinol. 5: 7-12.
28. Engelmann M, Ludwig M, Landgraf R. (1994). Simultaneous monitoring of intracerebral release and behavior: endogenous vasopressin improves social recognition. J Neuroendocrinol. 6: 391-395.
29. Alonso G, Szafarczyk A, Assenmacher I. (1986). Radioautographic evidence that axons from the area of supraoptic nuclei in the rat project to extrahypothalamic brain regions. Neuroscience Lett. 66: 251-256.
30. Theodosis DT, Montagnese C, Rodriguez F, Vincent JD, Poulain DA. (1986). Oxytocin induces morphological plasticity in the adult hypothalamo-neurohypophysial system. Nature. 322: 738-740.
31. Montagnese C, Poulain DA, Theodosis DT. (1990). Influence of ovarian steroids on the ultrastructural plasticity of the adult rat supraoptic nucleus induced by central administration of oxytocin. J Neuroendocrinol. 2: 226-231.
32. Modney BK, Hatton GI. (1994). Maternal behaviors: evidence that they feed back to alter brain morphology and function. Acta Paediatr Suppl. 397: 29-32.
33. Antonijevics IA, Douglas AJ, Dye S, Bicknell RJ, Leng G, Luckman SM, Russell JA. (1995). Oxytocin antagonists delay the initiation of parturition and prolong its active phase in rats. J Endocrinol. 145: 97-103.
34. Ingram CD, Adams TST, Jiang QB, Terenzi MG, Lambert RC, Wakerley JB, Moos F. (1995). Limbic regions mediating central actions of oxytocin on the milk-ejection reflex in the rat. J Neuroendocrinol. 7: 1-13.
35. Manning M, Sawyer WH. (1989). Discovery, development, and some uses of vasopressin and oxytocin antagonists. J Lab Clin Med. 617-632.
36. Paxinos G, Watson C. (1986). The rat brain in stereotaxic coordinates. Academic Press, Sydney.
37. Landgraf R. (1981). Simultaneous measurement of arginine vasopressin and oxytocin in plasma and neurohypophysis by radioimmunoassay. Endokrinologie. 78: 191-204.