Acute exposure to caffeine decreases the anticonvulsant action of ethosuximide, but not that of clonazepam, phenobarbital and valproate against pentetrazole-induced seizures in mice

Pharmacological Reports

Volumn 58, Issue 5, 2006, Pages 652-659

  Łuszczki, Jarogniew J ^a   Zuchora, Marek ^a   Sawicka, Katarzyna M ^a   Kozińska, Justyna ^a   Czuczwar, Stanisław J ^a,b  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

Author keywords

Antiepileptic drugs; Caffeine; Ethosuximide; Pentetrazole; Pharmacodynamic interaction

Indexed keywords

CAFFEINE BENZOATE; CLONAZEPAM; ETHOSUXIMIDE; PENTETRAZOLE; PHENOBARBITAL; SODIUM CHLORIDE; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; BEVERAGE; CLONIC SEIZURE; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG CONTRAINDICATION; DRUG DOSE REGIMEN; FOOD DRUG INTERACTION; MALE; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PHARMACODYNAMICS;

EID: 33750968208     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Albertson TE, Joy RM, Stark LG: Caffeine modification of kindled amygdaloid seizures. Pharmacol Biochem Behav, 1983, 19, 339-343.
2. Boissier JR, Tardy J, Diverres JC: Une nouvelle méthode simple pour explorer l'action tranquilisante: le test de la cheminée. Med Exp (Basel), 1960, 3, 81-84.
3. Bonilha L, Li LM: Heavy coffee drinking and epilepsy. Seizure, 2004, 13, 284-285.
4. Choi OH, Shamim MT, Padgett WL, Daly JW: Caffeine and theophylline analogues: correlation of behavioral effects with activity as adenosine receptor antagonists and as phosphodiesterase inhibitors. Life Sci, 1988, 43, 387-398.
5. Coulter DA, Huguenard JR, Prince DA: Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. Ann Neurol, 1998, 25, 582-593.
6. Crunelli V, Leresche N: Block of thalamic T-type Ca(2+) channels by ethosuximide is not the whole story. Epilepsy Curr, 2002, 2, 53-56.
7. Czuczwar SJ, Gasior M, Janusz W, Szczepanik B, Wlodarczyk D, Kleinrok Z: Influence of different methylxanthines on the anticonvulsant action of common antiepileptic drugs in mice. Epilepsia, 1990, 31, 318-323.
8. Finney DJ: Probit analysis, 3rd edn., Cambridge University Press, London, UK, 1971.
9. Fredholm BB, Battig K, Holmen J, Nehlig A, Zvartau EE: Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev, 1999, 51, 83-133.
10. Gasior M, Borowicz Y, Buszewicz G, Kleinrok Z, Czuczwar SJ: Anticonvulsant activity of phenobarbital and valproate against maximal electroshock in mice during chronic treatment with caffeine and caffeine discontinuation. Epilepsia, 1996, 37, 262-268.
11. Glantz SA, Slinker BK: Primer of applied regression and analysis of variance, 2nd edn., McGraw-Hill Inc., New York, 2001.
12. Gomora JC, Daud AN, Weiergraber M, Perez-Reyes E: Block of cloned human T-type calcium channels by succinimide antiepileptic drugs. Mol Pharmacol, 2001, 60, 1121-1132.
13. Goto M, Morishita S, Fukuda H: Anticonvulsant action of diazepam in mice pretreated with caffeine. J Pharmacobiodyn, 1983, 6, 654-659.
14. Kaufman KR, Sachdeo RC: Caffeinated beverages and decreased seizure control. Seizure, 2003, 12, 519-521.
15. Kulkarni C, Joseph T, David J: Influence of adenosine receptor antagonists, aminophylline and caffeine, on seizure protective ability of antiepileptic drugs in rats. Indian J Exp Biol, 1991, 29, 751-754.
16. Leresche N, Parri HR, Erdemli G, Guyon A, Turner JP, Williams SR, Asprodini E, Crunelli V: On the action of the anti-absence drug ethosuximide in the rat and cat thalamus. J Neurosci, 1998, 18, 4842-4853.
17. Litchfield JT, Wilcoxon F: A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther, 1949, 96, 99-113.
18. Löscher W, Honack D, Fassbender CP, Nolting B: The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models. Epilepsy Res, 1991, 8, 171-189.
19. Löscher W, Schmidt D: Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res, 1988, 2, 145-181.
20. Łuszczki JJ, Borowicz KK, Świader M, Czuczwar SJ: Interactions between oxcarbazepine and conventional antiepileptic drugs in the maximal electroshock test in mice: an isobolographic analysis, Epilepsia, 2003, 44, 489-499.
21. Łuszczki JJ, Czuczwar SJ: How significant is the difference between drug doses influencing the threshold for electroconvulsions? Pharmacol Rep, 2005, 57, 782-786.
22. Łuszczki JJ, Czuczwar SJ: Isobolographic characterisation of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model. Naunyn Schmiedebergs Arch Pharmacol, 2005, 372, 41-54.
23. Łuszczki JJ, Ratnaraj N, Patsalos PN, Czuczwar SJ: Isobolographic analysis of interactions between loreclezole and conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model. Naunyn Schmiedebergs Arch Pharmacol, 2006, 373, 169-181.
24. Łuszczki JJ, Wójcik-Ćwikła J, Andres MM, Czuczwar SJ: Pharmacological and behavioral characteristics of interactions between vigabatrin and conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis. Neuropsychopharmacology, 2005, 30, 958-973.
25. Marangos PJ, Martino AM, Paul SM, Skolnick P: The benzodiazepines and inosine antagonize caffeine-induced seizures. Psychopharmacology (Berl), 1981, 72, 269-273.
26. Morgan PF, Deckert J, Jacobson KA, Marangos PJ, Daly JW: Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC). Life Sci, 1989, 45, 719-728.
27. Motulsky HJ, Christopoulos A: Fitting models to biological data using linear and nonlinear regression. A practical guide to curve fitting. Graph Pad Software Inc., San Diego CA, USA, 2003.
28. Nehlig A, Daval JL, Debry G: Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res Rev, 1992, 17, 139-170.
29. www.nap.edu/readingroom/books/labrats/