Design of endoperoxides with anti-Candida activity

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 1, 2007, Pages 36-42

  Avery, Thomas D ^a   Macreadie, Peter I ^b   Greatrex, Ben W ^a   Robinson, Tony V ^a   Taylor, Dennis K ^a   Macreadie, Ian G ^b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b CSIRO   (Australia)

Author keywords

Antifungal; Artemisinin; Candida; Endoperoxide; Growth inhibition; Hemolytic activity

Indexed keywords

(5 METHYLPERHYDROOXIRENO[2,3 D][1,2]DIOXIN 2 YL)METHANOL; (5 METHYLPERHYDROOXIRENO[2,3 D][1,2]DIOXIN 2 YL)METHYL 2 (3 BROMOADAMANTYL)ACETATE; (5 METHYLPERHYDROOXIRENO[2,3 D][1,2]DIOXIN 2 YL)METHYL 2 ADAMANTYLACETATE; (5 METHYLPERHYDROOXIRENO[2,3 D][1,2]DIOXIN 2 YL)METHYLBENZYL ETHER; 2 (1 ADAMANTYLMETHYL)PERHYDROOXIRENO[2,3 D][1, 2]DIOXINE; 2 HEPTYL 1A HEXYLPERHYDROOXIRENO[2,3 D][1,2]DIOXINE; 2 HEPTYLPERHYDROOXIRENO[2,3 D][1,2]DIOXINE; 2,5 BIS[(BENZYLOXY)METHYL]PERHYDROOXIRENO[2,3 D][1,2]DIOXINE; 2,5 DIADAMANTYLPERHYDROOXIRENO[2,3 D][1,2]DIOXINE; 3 (1 ADAMANTYLMETHYL) 3,6 DIHYDRO 1,2 DIOXINE; 3 [(BENZYLOXY)METHYL] 6 METHYL 3,6 DIHYDRO 1,2 DIOXINE; 3 HEPTYL 4 HEXYL 3,6 DIHYDRO 1,2 DIOXINE; 3,6 BIS[(BENZYLOXY)METHYL] 3,6 DIHYDRO 1,2 DIOXINE; 3,6 DIADAMANTYL 3,6 DIHYDRO 1,2 DIOXINE; 6 METHYL 3,6 DIHYDRO 1,2 DIOXIN 3 YLMETHYL 2 (3 BROMOADAMANTYL)ACETATE; 6 METHYL 3,6 DIHYDRO 1,2 DIOXIN 3 YLMETHYL 2 ADAMANTYLACETATE; AMPHOTERICIN B; ENDOPEROXIDE; KETOCONAZOLE; NYSTATIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; EPOXIDATION; FEMALE; HEMOLYSIS; IC 50; MAMMAL CELL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CELL PROLIFERATION; CHO CELLS; CRICETINAE; DRUG DESIGN; ERYTHROCYTES; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; PEROXIDES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

CANDIDA; CANDIDA ALBICANS; MAMMALIA;

EID: 33750964870     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.10.021     Document Type: Article

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