Effect of FTY720 in Rat Small Bowel Transplantation: Apoptosis of Crypt Cells and Lymphocytes in Gut-Associated Lymphoid Tissues

Transplantation Proceedings

Volumn 38, Issue 9, 2006, Pages 3058-3060

  Sugito, K ^a   Koshinaga, T ^a   Inoue, M ^a   Ikeda, T ^a   Hagiwara, N ^a   Kusafuka, T ^a   Fukuzawa, M ^a  

^a NIHON UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIBODY; FAS ANTIGEN; FAS LIGAND; FINGOLIMOD; PEROXIDASE;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNT; CELL LABELING; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; CRYPT CELL; CYTOLOGY; DOWN REGULATION; DRUG EFFECT; FEEDING; FROZEN SECTION; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; INTESTINE CELL; INTESTINE GRAFT; INTESTINE LYMPHATIC TISSUE; INTESTINE TRANSPLANTATION; ISOGRAFT; LYMPHOCYTE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PEYER PATCH; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RAT STRAIN; STATISTICAL SIGNIFICANCE; TISSUE SECTION; UPREGULATION;

ANIMALS; APOPTOSIS; FAS LIGAND PROTEIN; IMMUNOSUPPRESSIVE AGENTS; INTESTINAL MUCOSA; INTESTINE, SMALL; MODELS, ANIMAL; PEYER'S PATCHES; PROPYLENE GLYCOLS; RATS; RATS, INBRED BN; RATS, INBRED LEW; SPHINGOSINE; TRANSPLANTATION, HOMOLOGOUS; TRANSPLANTATION, ISOGENEIC;

EID: 33750963960     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2006.08.147     Document Type: Article

References (8)

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2. Fujita T., Yoneta M., Hirose R., et al. Simple compounds, 2-alkyl-2-amino-1, 3-propanediols have potent immunosuppressive activity. Bioorg Med Chem Lett 5 (1995) 847
3. Kiuchi M., Adachi K., Kohara T., et al. Synthesis and biological evaluation of 2,2-disubstituted 2-aminoethanols: analogues of FTY720. Bioorg Med Chem Lett 8 (1998) 101
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5. Park Y.J., Fujisaki S., Kimizuka K., et al. Apoptosis of crypt cells and lymphocytes in gut-associated lymphoid tissues during small intestinal graft rejection in rats. Transplant Proc 36 (2004) 353
6. Suzuki S., Enosawa S., Kakefuda T., et al. A novel immunosuppressant, FTY720, having an unique mechanism of action induces longterm graft acceptance in rat and dog allotransplantation. Transplantation 61 (1996) 200
7. Suzuki S., Li X.K., Enosawa S., et al. A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes. Immunology 89 (1996) 518
8. Chiba K., Yanagawa Y., Masubuchi Y., et al. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. J Immunol 160 (1998) 5037