Elevated Levels of Serum Interleukin-6 are Associated With Low Grade Cellular Rejection in Patients With Heart Transplantation

Transplantation Proceedings

Volumn 38, Issue 9, 2006, Pages 3012-3015

  Perez Villa, F ^a   Benito, B ^a   Llancaqueo, M ^a   Cuppoletti, A ^a   Roig, E ^a  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; INTERLEUKIN 1BETA; INTERLEUKIN 3 RECEPTOR; INTERLEUKIN 6; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OKT 3; PREDNISOLONE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CARDIAC GRAFT REJECTION; CONTROLLED STUDY; FEMALE; HEART MUSCLE BIOPSY; HEART TRANSPLANTATION; HUMAN; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

ADULT; BIOLOGICAL MARKERS; BIOPSY; CYTOKINES; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; INTERLEUKIN-6; RETROSPECTIVE STUDIES;

EID: 33750957681     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2006.08.113     Document Type: Article

References (18)

1. Bumgardner G.L., and Orosz C.G. Transplantation and cytokines. Sem liver Dis 19 (1999) 189
2. Deng M.C., Erren M., Kamerling L., et al. The relation of interleukin-6, tumor necrosis factor-α, IL-2, and IL-2 receptor levels to cellular rejection, allograft dysfunction, and clinical events early after cardiac transplantation. Transplantation 60 (1995) 1118
3. George J.F., Kirklin J.K., Naftel D.C., et al. Serial measurements of interleukin-6, interleukin-8, tumor necrosis factor-α, and soluble vascular cell adhesion molecule-1 in the peripheral blood plasma of human cardiac allograft recipients. J Heart Lung Transplant 16 (1997) 1046
4. Deng M.C., Erren M., Roeder N., et al. T-cell and monocyte subsets, inflammatory molecules, rejection, and hemodynamics early after cardiac transplantation. Transplantation 65 (1998) 1255
5. Deng M.C., Plenz G., Labarrere C., et al. The role of IL6 cytokines in acute cardiac allograft rejection. Transplant Immunol 9 (2002) 115
6. Billingham M.E., Cary N.R.B., Hammond E.M., et al. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. J Heart Lung Transplant 9 (1990) 587
7. Orus J., Roig E., Perez-Villa E., et al. Prognostic value of serum cytokines in patients with congestive heart failure. J Heart Lung Transplant 19 (2000) 419
8. Mosmann T.R., Cherwinski H., Bond M.W., et al. Two types of murine helper T-cell clone. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136 (1986) 2348
9. Romagnani S. Regulation of differentiation and role in protection and immunopathology. Int Arch Allergy Immunol 98 (1992) 279
10. Takeuchi T., Lowry R.P., and Konieczny B. Heart allografts in murine system. The differencial activation of Th2-like effector cells in peripheral tolerance. Transplantation 53 (1992) 1281
11. Van Besouw N.M., Daane C.R., Vaessen L.M., et al. Different patterns in donor-specific production of T-helper 1 and 2 cytokines by cells infiltrating the rejecting cardiac allograft. J Heart Lung Transplant 14 (1995) 816
12. Tomura M., Izumi N., Miho M., et al. Suppression of allograft responses induced by interleukin-6, which selectively modulates interferon-gamma but not interleukin-2 production. Transplantation 64 (1997) 757
13. Yamamoto N., Zou J.P., Li X.F., et al. Regulatory mechanisms for production of interferon-gamma and tumor necrosis factor by anti-tumor T cells and macrophages in the tumor-bearing state. J Immunol 154 (1995) 2281
14. Mizuhara H., O'Neill E., Seki N., et al. T cell activation associated with hepatic injury: mediation by tumor necrosis factor and protection by interleukin-6. J Exp Med 179 (1994) 1529
15. Mizuhara H., Uno M., Seki N., et al. Critical involvement of interferon-gamma in the patrogenesis of T cell activation-associated hepatitis and regulatory mechanisms of IL-6 for the manifestation of hepatitis. Hepatology 23 (1996) 1608
16. Fyfe A., Daly P., Galligan L., et al. Coronary sinus sampling of cytokines after heart transplantation: evidence for macrophage activation and interleukin-4 production within the graft. J Am Coll Cardiol 21 (1993) 171
17. Kimball P., Radovancevic B., Isom T., et al. The paradox of cytokine monitoring-predictor of immunologic activity as well as immunologic silence following cardiac transplantation. Transplantation 61 (1996) 909
18. Abdallah A.N., Billes M.A., Attia Y., et al. Evaluation of plasma levels of tumor necrosis factor alpha and interleukin-6 as rejection markers in a cohort of 142 heart-grafted patients followed by endomyocardial biopsy. Eur Heart J 18 (1997) 1024