Effects of the novel antiepileptic drug lacosamide on the development of amygdala kindling in rats

Epilepsia

Volumn 47, Issue 11, 2006, Pages 1803-1809

  Brandt, Claudia ^a   Heile, Anna ^a   Potschka, Heidrun ^a,b   Stoehr, Thomas ^c   Löscher, Wolfgang ^a,b  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b CENTER FOR SYSTEMS NEUROSCIENCE   (Germany)

^c Schwarz Pharma AG   (Germany)

Author keywords

Disease modification; Epilepsy; Epileptogenesis; Seizures

Indexed keywords

ANTICONVULSIVE AGENT; HARKOSERIDE;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG MECHANISM; EPILEPTOGENESIS; EXPERIMENTAL RAT; FEMALE; KINDLING; MOLECULAR BIOLOGY; NEUROPHARMACOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME;

ACETAMIDES; AMYGDALA; ANIMALS; ANTICONVULSANTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ELECTRODES, IMPLANTED; ELECTROENCEPHALOGRAPHY; EPILEPSY; FEMALE; KINDLING, NEUROLOGIC; RATS; RATS, WISTAR;

EID: 33750904279     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2006.00818.x     Document Type: Article

References (27)

1. Bialer M, Johannessen SI, Kupferberg HJ, Levy RH, Loiseau P, Perucca E. (2001) Progress report on new antiepileptic drugs: a summary of the Fifth Eilat Conference (EILAT V). Epilepsy Res 43:11-58.
2. Bialer M, Johannessen SI, Kupferberg HJ, Levy RH, Loiseau P, Perucca E. (2002) Progress report on new antiepileptic drugs: a summary of the Sixth Eilat Conference (EILAT VI). Epilepsy Res 51:31-71.
3. Bialer M, Johannessen SI, Kupferberg HJ, Levy RH, Perucca E, Tomson T. (2004) Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII). Epilepsy Res 61:1-48.
4. Brodie MJ. (2001) Do we need any more new antiepileptic drugs? Epilepsy Res 45:3-6.
5. Choi D, Stables JP, Kohn H. (1996) Synthesis and anticonvulsant activities of N-benzyl-2-acetamidopropionamide derivatives. J Med Chem 39:1907-1916.
6. Cortes S, Liao ZK, Watson D, Kohn H. (1985) Effect of structural modification of the hydantoin ring on anticonvulsant activity. J Med Chem 28:601-606.
7. Duncan GE, Kohn H. (2005) The novel antiepileptic drug lacosamide blocks behavioral and brain metabolic manifestations of seizure activity in the 6Hz psychomotor seizure model. Epilepsy Res 67:81-87.
8. Errington AC, Coyne L, Stohr T, Selve N, Lees G. (2006) Seeking a mechanism of action for the novel anticonvulsant lacosamide. Neuropharmacology 50:1016-1029.
9. Freeman FG, Jarvis MF. (1981) The effect of interstimulation interval on the assessment and stability of kindled seizure threshold. Brain Res Bull 7:629-633.
10. Hovinga CA. (2003) SPM-927 (Schwarz Pharma). IDrugs 6:479-485.
11. Lees G, Stohr T, Errington AC. (2006) Stereoselective effects of the novel anticonvulsant lacosamide against 4-AP induced epileptiform activity in rat visual cortex in vitro. Neuropharmacology 50:98-110.
12. Löscher W, Hönack D, Rundfeldt C. (1998) Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy. J Pharmacol Exp Ther 284:474-479.
13. Löscher W. (1999) Animal models of epilepsy and epileptic seizures. In Eadie MJ, Vajda F (Eds) Antiepileptic drugs. Handbook of experimental pharmacology. Springer, Berlin, pp. 19-62.
14. Löscher W. (2002a) Current status and future directions in the pharmacotherapy of epilepsy. Trends Pharmacol Sci 23:113-8.
15. Löscher W. (2002b) Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy. Epilepsy Res 50:105-23.
16. Löscher W, Schmidt D. (2004) New horizons in the development of antiepileptic drugs: the search for new targets. Epilepsy Res 60:77-159.
17. McIntyre DC, Poulter MO, Gilby K. (2002) Kindling: some old and some new. Epilepsy Res 50:79-92.
18. Paxinos G, Watson C. (1986) The rat brain in stereotaxic coordinates. 2nd ed. Academic Press, Sydney.
19. Perucca E, Gram L, Avanzini G, Dulac O. (1998) Antiepileptic drugs as a cause of worsening seizures. Epilepsia 39:5-17.
20. Perucca E, Kupferberg HJ. (2002) Drugs in early clinical development. In Levy RH, Mattson RH, Meldrum BS, Perucca E (Eds.) Antiepileptic drugs. 5th ed. Lippincott Williams & Wilkins, Philadelphia, pp. 913-928.
21. Pitkänen A. (2002a) Efficacy of current antiepileptics to prevent neurodegeneration in epilepsy models. Epilepsy Res 50:141-160.
22. Pitkänen A. (2002b) Drug-mediated neuroprotection and antiepileptogenesis: animal data. Neurology 59:S27-S33.
23. Pitkänen A. (2004) New pharmacotherapy for epilepsy. IDrugs 7:471-477.
24. Pitkänen A, Kubova H. (2004) Antiepileptic drugs in neuroprotection. Expert Opin Pharmacother 5:777-798.
25. Racine RJ. (1972) Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroenceph Clin Neurophysiol 32:281-294.
26. Somerville ER. (2002) Aggravation of partial seizures by antiepileptic drugs: is there evidence from clinical trials? Neurology 59:79-83.
27. Stratton SC, Large CH, Cox B, Davies G, Hagan RM. (2003) Antiepileptogenic-like effects of lamotrigine in a rat amygdala kindling model. Epilepsy Res 53:95-106.