High-dose lidocaine does not affect defibrillation efficacy: Implications for defibrillation mechanisms

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 274, Issue 4 43-4, 1998, Pages

  Ujhelyi, Michael R ^a   Sims, J Jason ^a   Miller, Allison Winecoff ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Electrical stimulation; Electropharmacology; Electrophysiology; Ion conductance; Ventricular defibrillation; Ventricular fibrillation

Indexed keywords

ANTIARRHYTHMIC AGENT; LIDOCAINE; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHRONOTROPISM; CLINICAL ARTICLE; CONTROLLED STUDY; DEFIBRILLATION; DOSE RESPONSE; DRUG MEGADOSE; ELECTROCARDIOGRAM; ELECTROPHYSIOLOGY; ELECTROSTIMULATION; HEART VENTRICLE CONDUCTION; HEART VENTRICLE FIBRILLATION; ION CONDUCTANCE; NONHUMAN; PRIORITY JOURNAL; REPOLARIZATION; SWINE; TREATMENT OUTCOME;

EID: 33750870528     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1998.274.4.h1113     Document Type: Article

References (33)

1. Abildskov, J. A. Induced termination of fibrillation. J. Cardiovasc. Electrophysiol. 7: 71-81, 1996.
2. Anderson, K. P., R. Walker, R. L. Lux, P. R. Ershler, R. Menlove, M. R. Williams, R. Krall, and D. Moddrelle. Conduction velocity depression and drug-induced ventricular tachyarrhythmias: effects of lidocaine in the intact canine heart. Circulation 81: 1024-1038, 1990.
3. Babbs, C. F. Effect of pentobarbital anesthesia on ventricular defibrillation threshold in dogs. Am. Heart J. 95: 331-337, 1978.
4. Bonometti, C., C. Hwang, D. Hough, J. J. Lee, M. C. Fishbein, H. Karagueuzian, and P.-S. Chen. Interaction between strong electrical stimulation and reentrant wavefronts in canine ventricular fibrillation. Circ. Res. 77: 407-416, 1995.
5. Cha, Y.-M., B. B. Peters, and P.-S. Chen. The effects of lidocaine on the vulnerable period during ventricular fibrillation. J. Cardiovasc. Electrophysiol. 5: 571-580, 1994.
6. Colatsky, T. J. Mechanisms of action of lidocaine and quinidine on action potential duration in rabbit cardiac Purkinje fibers: an effect on steady state sodium currents? Circ. Res. 50: 17-27, 1982.
7. Damle, R. S., N. S. Robinson, D. Z. Ye, S. I. Roth, R. Greene, J. J. Goldberger, and A. H. Kadish. Electrical activation during ventricular fibrillation in the subacute and chronic phases of healing canine myocardial infarction. Circulation 92: 535-545, 1995.
8. Dillon, S. M. Synchronized repolarization after defibrillation: a possible component of the defibrillation process demonstrated by optical recordings in rabbit heart. Circulation 85: 1865-1878, 1992.
9. Dorian, P., E. S. Fain, J.-M. Davy, and R. A. Winkle. Lidocaine causes a reversible, concentration-dependent increase in defifarillation energy requirements. J. Am. Coll. Cardiol. 8: 327-332, 1986.
10. Dorian, P., and D. Newman. Tedisamil increases coherence during ventricular fibrillation and decreases defibrillation energy requirements. Cardiovasc. Res. 33: 485-494, 1997.
11. Dorian, P., D. Newman, R. Sheahan, A. Tang, M. Green, and J. Mitchell. d-Sotalol decreases defibrillation energy requirements in humans: a novel indication for drug therapy. J. Cardiovasc. Electrophysiol. 7: 952-961, 1996.
12. Dorian, P., P. A. Penkoske, and F. X. Witkowski. Order in disorder: effect of barium on ventricular fibrillation. Can. J. Cardiol. 12: 399-406, 1996.
13. Echt, D. S., J. N. Black, J. T. Barbey, D. R. Coxe, and E. Cato. Evaluation of antiarrhythmic drugs on defibrillation energy requirements in dogs. Sodium channel block and action potential prolongation. Circulation 79: 1106-1117, 1989.
14. Fain, E. S., P. Dorian, J.-M. Davy, R. E. Kates, and R. A. Winkle. Effects of encainide and its metabolites on energy requirements for defibrillation. Circulation 73: 397-405, 1986.
15. Hillsley, R. E., J. M. Wharton, A. W. Case, P. D. Wolf, and R. E. Ideker. Why do some patients have high defibrillation thresholds at defibrillator implantation? Answers from basic research. Pacing Clin. Electrophysiol. 17: 222-239, 1994.
16. Jalife, J., J. M. Davidenko, and D. C. Michaels. A new perspective on the mechanisms of arrhythmias and sudden cardiac death: spiral waves of excitation in heart muscle. J. Cardiovasc. Electrophysiol. 2: S133-S152, 1991.
17. Kodama, I., N. Shibata, I. Sakuma, K. Mitsui, M. Iida, R. Suzuki, Y. Fukui, S. Hosoda, and J. Toyama. Aftereffects of high-intensity DC stimulation on the electromechanical performance of ventricular muscle. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H248-H258, 1994.
18. Kwaku, K. F., and S. M. Dillon. Shock-induced depolarization of refractory myocardium prevents wave-front propagation in defibrillation. Circ. Res. 79: 957-973, 1996.
19. Nattel, S., G. Bourne, and M. Talajic. Insights into mechanisms of antiarrhythmic drug action from experimental models of atrial fibrillation. J. Cardiovasc. Electrophysiol. 8: 469-480, 1997.
20. Rensma, P. L., M. A. Allessie, W. J. Lammers, F. I. M. Bonke, and M. J. Schalij. Length of excitation wave and susceptibility to reentrant atrial arrhythmias in normal conscious dogs. Circ. Res. 62: 395-410, 1988.
21. Shah, S. S., P. W. E. Hsia, G. Harrington, and R. J. Daminao. Quantifying myocardial organization using coherence analysis during ventricular fibrillation and for defibrillation research: a single reference electrode approach. In: Computers in Cardiology. Los Alamitos, CA: IEEE Computer Soc., 1995, p. 801-804.
22. Ujhelyi, M. R., S. Oskouei, A. P. Winecoff, S. Carter, S. Li, and M. L. Markel. Dispersion in post-shock activations predicts defibrillation success during lidocaine (Abstract). Circulation 94: 1132, 1996.
23. Ujhelyi, M. R., M. Schur, T. Frede, M. B. Bottorff, M. Gabel, and M. L. Markel. Hypertonic saline does not reverse the sodium channel blocking actions of lidocaine: evidence from electrophysiologic and defibrillation studies. J. Cardiovasc. Pharmacol. 29: 61-68, 1997.
24. Ujhelyi, M. R., M. Schur, T. Frede, M. B. Bottorff, M. Gabel, and M. L. Markel. Mechanisms of antiarrhythmic drug-induced changes in defibrillation threshold: role of potassium and sodium channel conductance. J. Am. Coll. Cardiol. 27: 1534-1542, 1996.
25. Ujhelyi, M. R., M. Schur, T. Frede, M. Gabel, and M. L. Markel. Differential effects of lidocaine on defibrillation threshold with monophasic versus biphasic shock waveforms. Circulation 92: 1644-1650, 1995.
26. Ujhelyi, M. R., A. P. Winecoff, M. Schur, T. Frede, M. B. Bottorff, M. Gabel, and M. L. Markel. Influence of hypertonic saline infusion on defibrillation efficacy. Chest 110: 784-790, 1996.
27. Wang, Z., P. Page, and S. Nattel. Mechanisms of flecainide's antiarrhythmic action in experimental atrial fibrillation. Circ. Res. 71: 271-287, 1992.
28. Wesley, R. C., F. Farkhani, D. Morgan, and D. Zimmerman. Ibutilide: enhanced defibrillation via plateau sodium current activation. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H1269-H1274, 1993.
29. ATP channel. J. Cardiovasc. Pharmacol. Ther. 2: 171-79, 1997.
30. Witkowski, F. X., P. A. Penkoske, and R. Plonsey. Mechanism of cardiac defibrillation in open-chest dogs with unipolar DC-coupled simultaneous activation and shock potential recordings. Circulation 82: 244-260, 1990.
31. Zhou, X., J. P. Daubert, P. D. Wolf, W. M. Smith, and R. E. Ideker. Epicardial mapping of ventricular defibrillation with monophasic and biphasic shocks in dogs. Circ. Res. 72: 145-160, 1993.
32. Zhou, X., P. Guse, P. D. Wolf, D. L. Rolling, W. M. Smith, and R. E. Ideker. Existence of both fast and slow channel activity during the early stages of ventricular fibrillation. Circ. Res. 71: 773-786, 1992.
33. Zhou, Z., W. M. Smith, D. L. Rollins, and R. E. Ideker. Transmembrane potential changes caused by shocks in guinea pig papillary muscle. Am. J. Physiol. 271 (Heart Circ. Physiol. 40): H2536-H2546, 1996.