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Volumn 6, Issue , 2006, Pages 1247-1261

Pharmacologic targets and prototype therapeutics in the kallikrein-kinin system: Bradykinin receptor agonists or antagonists

Author keywords

Bradykinin; Bradykinin agonists; Bradykinin antagonists; Cardioprotection; Inflammation; Kallikrein kinin system

Indexed keywords

1,4 DIHYDROPYRIDINE DERIVATIVE; 3 (6 ACETAMIDO 3 PYRIDYL) N [N [2,4 DICHLORO 3 [(2 METHYL 8 QUINOLINYL)OXYMETHYL]PHENYL] N METHYLAMINOCARBONYLMETHYL]ACRYLAMIDE; 3 BROMO 8 [2,6 DICHLORO 3 [N [4 (N,N DIMETHYLCARBAMOYL)CINNAMIDOACETYL] N METHYLAMINO]BENZYLOXY] 2 METHYLIMIDAZO[1,2 A]PYRIDINE; 8 [2,6 DICHLORO 3 [N [4 (N METHYLCARBAMOYL)CINNAMAMIDOACETYL] N METHYLAMINO]BENZYLOXY] 2 METHYL 4 (2 PYRIDYLMETHOXY)QUINOLINE; 8 [2,6 DICHLORO 3 [N [4 (N METHYLCARBAMOYL)CINNAMAMIDOACETYL] N METHYLAMINO]BENZYLOXY] 2 METHYLQUINOLINE; [[4 [2 [[BIS(CYCLOHEXYLAMINO)METHYLENE]AMINO] 3 (2 NAPHTHYL)PROPIONAMIDO]PHENYL]METHYL]TRIBUTYLPHOSPHONIUM CHLORIDE; [LEUCYL 8 ]DES ARGINYL 9 BRADYKININ; ACETYLLYSYLBRADYKININ[7 [3 (2 NAPHTHYL)ALANINE] 8 ISOLEUCINE 9 DEARGININE]; BRADYKININ; BRADYKININ ANTAGONIST; BRADYKININ B1 RECEPTOR; BRADYKININ B2 RECEPTOR; BRADYKININ RECEPTOR AGONIST; BRADYZIDE; CP 2522; FR 184280; ICATIBANT; KALLIKREIN; KININOGEN; L 755807; LABRADIMIL; LYSYL[LEUCYL 8 ]DES ARGINYL 9 BRADYKININ; LYSYLLYSYLARGINYLPROLYL(4 HYDROXYPROLYL)GLYCYL 2 (2,3 DIHYDRO 1H INDEN 2 YL)GLYCYLSERYL 2 (2,3 DIHYDRO 1H INDEN 2 YL)GLYCYLOCTAHYDRO 1H INDOLE 2 CARBOXYLIC ACID; MARTINELLINE; PHOSPHONIUM DERIVATIVE; PS 020990; QUINOLINE DERIVATIVE; SSR 240612; UNCLASSIFIED DRUG; UNINDEXED DRUG; WIN 62318;

EID: 33750828145     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/tsw.2006.226     Document Type: Article
Times cited : (24)

References (30)
  • 1
    • 0026556434 scopus 로고
    • Bioregulation of kinins: Kallikreins, kininogens, and kininases
    • Bhoola, K.D., Figueroa, C.D., and Worthy, K. (1992) Bioregulation of kinins: kallikreins, kininogens, and kininases. Pharmacol. Rev. 44, 1-80.
    • (1992) Pharmacol. Rev. , vol.44 , pp. 1-80
    • Bhoola, K.D.1    Figueroa, C.D.2    Worthy, K.3
  • 3
    • 0033005640 scopus 로고    scopus 로고
    • Identification of kallidin degrading enzymes in the isolated perfused rat heart
    • Wolfrum, S., Dendorfer, A., and Dominiak, P. (1999) Identification of kallidin degrading enzymes in the isolated perfused rat heart. Jpn. J. Pharmacol. 79, 117-120.
    • (1999) Jpn. J. Pharmacol. , vol.79 , pp. 117-120
    • Wolfrum, S.1    Dendorfer, A.2    Dominiak, P.3
  • 4
    • 0035112754 scopus 로고    scopus 로고
    • Ligand mediated regulation of kinin receptors in the rabbit
    • Marceau, F. et al. (2001) Ligand mediated regulation of kinin receptors in the rabbit. Biol. Chem. 382, 131-133.
    • (2001) Biol. Chem. , vol.382 , pp. 131-133
    • Marceau, F.1
  • 5
    • 9044242645 scopus 로고    scopus 로고
    • Reduced gene expression of vascular endothelial NO synthase and cyclooxygenase in heart failure
    • Smith, C.J. et al. (1996) Reduced gene expression of vascular endothelial NO synthase and cyclooxygenase in heart failure. Circ. Res. 78, 58-64.
    • (1996) Circ. Res. , vol.78 , pp. 58-64
    • Smith, C.J.1
  • 6
    • 0033812122 scopus 로고    scopus 로고
    • Bradykinin B1 receptor mediates inhibition of neointima formation in rat artery after balloon angioplasty
    • Agata, J. et al. (2000) Bradykinin B1 receptor mediates inhibition of neointima formation in rat artery after balloon angioplasty. Hypertension 36, 364-370.
    • (2000) Hypertension , vol.36 , pp. 364-370
    • Agata, J.1
  • 7
    • 0035379715 scopus 로고    scopus 로고
    • The bradykinin B1 receptor promotes angiogenesis by up regulation of endogenous FGF-2 in endothelium via the nitric oxide synthase pathway
    • Parenti, A. et al. (2001) The bradykinin B1 receptor promotes angiogenesis by up regulation of endogenous FGF-2 in endothelium via the nitric oxide synthase pathway. FASEB J. 15, 1487-1489.
    • (2001) FASEB J. , vol.15 , pp. 1487-1489
    • Parenti, A.1
  • 8
    • 0037162482 scopus 로고    scopus 로고
    • Bradykinin-12-lipooxygenase-VR1 signaling pathway for inflammatory hyperalgesia
    • Shin, J. et al. (2002) Bradykinin-12-lipooxygenase-VR1 signaling pathway for inflammatory hyperalgesia. Proc. Natl. Acad. Sci. U. S. A. 99, 10150-10155.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 10150-10155
    • Shin, J.1
  • 9
    • 22544487505 scopus 로고    scopus 로고
    • Immunolocalization and expression of kinin B1R and B2R in human inflammatory bowel disease
    • Stadnicki, A. et al. (2005) Immunolocalization and expression of kinin B1R and B2R in human inflammatory bowel disease. Am. J. Physiol. Gastrointest. Liver Physiol. 289, 6361-6366.
    • (2005) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.289 , pp. 6361-6366
    • Stadnicki, A.1
  • 10
    • 0035041069 scopus 로고    scopus 로고
    • Kinin receptors and their antagonists as novel therapeutic agents
    • Yusuf Ozturk. (2001) Kinin receptors and their antagonists as novel therapeutic agents. Curr. Pharm. Des. 7, 135-161.
    • (2001) Curr. Pharm. Des. , vol.7 , pp. 135-161
    • Ozturk, Y.1
  • 11
    • 0035076062 scopus 로고    scopus 로고
    • Bradykinin receptor antagonist type 2 attenuate the inflammatory changes in peptidoglycan induced acute arthritis in the Lewis rat
    • Uknis, A.B. et al. (2001) Bradykinin receptor antagonist type 2 attenuate the inflammatory changes in peptidoglycan induced acute arthritis in the Lewis rat. Inflamm. Res. 50, 149-155.
    • (2001) Inflamm. Res. , vol.50 , pp. 149-155
    • Uknis, A.B.1
  • 12
    • 0033999859 scopus 로고    scopus 로고
    • 2 trasgenic knockout mice
    • 2 trasgenic knockout mice. Br. J. Pharmacol. 129, 1732-1738.
    • (2000) Br. J. Pharmacol. , vol.129 , pp. 1732-1738
    • Samadfam, R.1
  • 14
    • 0038811842 scopus 로고    scopus 로고
    • 2 receptor agonists in the treatment of cardiovascular disease
    • 2 receptor agonists in the treatment of cardiovascular disease. Expert Opin. Investig. Drugs 12, 759-770.
    • (2003) Expert Opin. Investig. Drugs , vol.12 , pp. 759-770
    • Heitsch, H.1
  • 15
    • 0842289491 scopus 로고    scopus 로고
    • Mediators of bradykinin induced vasorelaxation in human coronary microarteries
    • Batenburg, W.W. et al. (2004) Mediators of bradykinin induced vasorelaxation in human coronary microarteries. Hypertension 43, 488-492.
    • (2004) Hypertension , vol.43 , pp. 488-492
    • Batenburg, W.W.1
  • 16
    • 0035103962 scopus 로고    scopus 로고
    • 2 receptor knockout mice
    • 2 receptor knockout mice. Hypertension 37, 967-973.
    • (2001) Hypertension , vol.37 , pp. 967-973
    • Cerveuka, L.1
  • 17
    • 0242551429 scopus 로고    scopus 로고
    • 2 receptor is required for full expression renal COX-2 and renin
    • 2 receptor is required for full expression renal COX-2 and renin. Peptides 24, 1141-1147.
    • (2003) Peptides , vol.24 , pp. 1141-1147
    • Imig, J.D.1
  • 18
    • 0036324650 scopus 로고    scopus 로고
    • 2 receptor activation reduces renal fibrosis
    • 2 receptor activation reduces renal fibrosis. Jelin Investig. 110, 371-379.
    • (2002) Jelin Investig. , vol.110 , pp. 371-379
    • Schanstra, J.P.1
  • 19
    • 0037141858 scopus 로고    scopus 로고
    • Two ACEs and a heart
    • Bernstein, K.E. (2002) Two ACEs and a heart. J. Nat. 471, 799-802.
    • (2002) J. Nat. , vol.471 , pp. 799-802
    • Bernstein, K.E.1
  • 20
    • 0035168589 scopus 로고    scopus 로고
    • Tissue kallikrein KLK is expressed de novo in endothelial cells and mediates relaxation of human umbilical veins
    • Dedio, J. et al. (2001) Tissue kallikrein KLK is expressed de novo in endothelial cells and mediates relaxation of human umbilical veins. Biol. Chem. 382, 1483-1490.
    • (2001) Biol. Chem. , vol.382 , pp. 1483-1490
    • Dedio, J.1
  • 21
    • 0031911945 scopus 로고    scopus 로고
    • Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mk1, mk9, mk13, and mk22)
    • Kikkawa, Y. et al. (1998) Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mk1, mk9, mk13, and mk22). Biochim. Biophys. Acta 1382, 55-64.
    • (1998) Biochim. Biophys. Acta , vol.1382 , pp. 55-64
    • Kikkawa, Y.1
  • 22
    • 0034785580 scopus 로고    scopus 로고
    • Increased AT1 receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness
    • AbdAlla, S. et al. (2001) Increased AT1 receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness. J. Nat. Med. 7, 1003-1009.
    • (2001) J. Nat. Med. , vol.7 , pp. 1003-1009
    • Abdalla, S.1
  • 23
    • 14144251086 scopus 로고    scopus 로고
    • International union of pharmacology. XLV. Classification of the kinin receptor family: From molecular mechanisms to pathophysiological consequences
    • Leeb-Lundberg, L.M. et al. (2005) International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol. Rev. 57, 27-77.
    • (2005) Pharmacol. Rev. , vol.57 , pp. 27-77
    • Leeb-Lundberg, L.M.1
  • 24
    • 0035850304 scopus 로고    scopus 로고
    • First total synthesis of martinellic acid, a naturally occurring bradykinin receptor antagonist
    • Ma, D. et al. (2001) First total synthesis of martinellic acid, a naturally occurring bradykinin receptor antagonist. J. Org. Lett. 3, 2189-2191.
    • (2001) J. Org. Lett. , vol.3 , pp. 2189-2191
    • Ma, D.1
  • 25
    • 0038399929 scopus 로고    scopus 로고
    • Facilitation of drug entry into the CNS via transient permeation of blood brain barrier: Laboratory and preliminary clinical evidences from bradykinin receptor agonist, cereport
    • Borlongan, C.V. and Emerich, D.F. (2003) Facilitation of drug entry into the CNS via transient permeation of blood brain barrier: laboratory and preliminary clinical evidences from bradykinin receptor agonist, cereport. Brain Res. Bull. 60, 297-306.
    • (2003) Brain Res. Bull. , vol.60 , pp. 297-306
    • Borlongan, C.V.1    Emerich, D.F.2
  • 26
    • 0031716315 scopus 로고    scopus 로고
    • Traumatic brain contusions: A clinical role for the kinin antagonist CP-0127
    • Narotam, P.K. et al. (1998) Traumatic brain contusions: a clinical role for the kinin antagonist CP-0127. J. Acta Neurochir. (Wien) 140, 793-802.
    • (1998) J. Acta Neurochir. (Wien) , vol.140 , pp. 793-802
    • Narotam, P.K.1
  • 27
    • 0037103138 scopus 로고    scopus 로고
    • Upregulation of functional kinin B1 receptors in allergic airway inflammation
    • Christiansen, S.C. et al. (2002) Upregulation of functional kinin B1 receptors in allergic airway inflammation. J. Immunol. 169, 2054-2060.
    • (2002) J. Immunol. , vol.169 , pp. 2054-2060
    • Christiansen, S.C.1
  • 28
    • 0141649387 scopus 로고    scopus 로고
    • Bradykinin antagonist as anticancer agents
    • Stewart, J.M. (2003) Bradykinin antagonist as anticancer agents. Curr. Pharm. Des. 9, 2036-2042.
    • (2003) Curr. Pharm. Des. , vol.9 , pp. 2036-2042
    • Stewart, J.M.1
  • 29
    • 0142103703 scopus 로고    scopus 로고
    • Does the kinin system mediate in cardiovascular abnormalities? An overview
    • Sharma, J.N. (2003) Does the kinin system mediate in cardiovascular abnormalities? An overview. J. Clin. Pharmacol. 43(11), 1187-1195.
    • (2003) J. Clin. Pharmacol. , vol.43 , Issue.11 , pp. 1187-1195
    • Sharma, J.N.1
  • 30
    • 25444504534 scopus 로고    scopus 로고
    • The kallikrein-kinin system: Current and future pharmacological targets
    • Moreau, M.E. et al. (2005) The kallikrein-kinin system: current and future pharmacological targets. J. Pharmacol. Sci. 99, 15-16.
    • (2005) J. Pharmacol. Sci. , vol.99 , pp. 15-16
    • Moreau, M.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.