Identification of kallidin degrading enzymes in the isolated perfused rat heart

Japanese Journal of Pharmacology

Volumn 79, Issue 1, 1999, Pages 117-120

  Wolfrum, Sebastian ^a   Dendorfer, Andreas ^a   Dominiak, Peter ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Aminopeptidase M; Kallidin; Kinin metabolism

Indexed keywords

AMASTATIN; ARGININE CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE; KALLIDIN; KININASE; MEMBRANE METALLOENDOPEPTIDASE; MICROSOMAL AMINOPEPTIDASE; PHOSPHORAMIDON; RAMIPRILAT;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATED HEART; MALE; NONHUMAN; RAT;

EID: 0033005640     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.79.117     Document Type: Article

References (17)

1. Bhoola KD, Figueroa CD and Worthy K: Bioregulation of kinins: kallikreins, kininogens, and kininases. Pharmacol Rev 44, 4-81 (1992)
2. Auch-Schwelk W, Bossaller C, Claus M, Graf K, Gräfe M and Fleck E: ACE inhibitors are endothelium dependent vasodilators of coronary arteries during submaximal stimulation with bradykinin. Cardiovasc Res 27, 312-317 (1993)
3. 9-bradykinin by angiotensin converting enzyme. Biochem Pharmacol 35, 1951-1956 (1986)
4. Nolly H, Carbini LA, Scicli G, Carretero OA and Scicli AG: A local kallikrein-kinin system is present in rat hearts. Hypertension 23, 919-923 (1994)
5. Ito K, Zhu YZ, Zhu YC, Gohlke P and Unger T: Contribution of bradykinin to the cardioprotective action of angiotensin converting enzyme inhibition in hypertension and after myocardial infarction. Jpn J Pharmacol 75, 311-318 (1997)
6. Dendorfer A, Wolfrum S, Wellhöner P, Korsman K and Dominiak P: Intravascular and interstitial degradation of bradykinin in isolated perfused rat heart. Br J Pharmacol 122, 1179-1187 (1997)
7. Dendorfer A, Vordermark D and Dominiak P: Degradation of bradykinin by bovine tracheal epithelium and isolated epithelial cells. Br J Pharmacol 120, 121-129 (1997)
8. Orawski AT and Susz JP: Metabolism of bradykinin by multipie coexisting membrane-bound peptidases in lung: techniques for investigating the role of each peptidases using specific inhibitors. Adv Exp Med Biol 247B, 355-364 (1989)
9. Gillespie TJ, Konings PN, Merrill BJ and Davis TP: A specific enzyme assay for aminopeptidase M in rat brain. Life Sci 51, 2097-2106 (1992)
10. Unger T, Moursi M, Ganten D, Hermann K and Lang RE: Antihypertensive action of converting enzyme inhibitor perindopril (S9490) in spontaneously hypertensive rats: comparison with enalapril (MK421) and ramipril (HOE498). J Cardiovasc Pharmacol 8, 276-285 (1986)
11. Sheikh IA and Kaplan AP: Studies of the digestion of bradykinin, lys-bradykinin, and kinin-degadation products by carboxypeptidases A, B, and N. Biochem Pharmacol 35, 1957-1963 (1986)
12. Palmieri FE, Bausback HH and Ward PE: Metabolism of vasoactive peptides by vascular endothelium and smooth muscle aminopeptidase M. Biochem Pharmacol 38, 173-180 (1989)
13. Palmieri FE and Ward PE: Vascular, plasma membrane aminopeptidase M. Metabolism of vasoactive peptides. Biochem Pharmacol 34, 2309-2317 (1985)
14. Ward PE, Benter IF and Wilk S: Metabolism of vasoactive peptides by plasma and purified renal aminopeptidase M. Biochem Pharmacol 40, 1725-1732 (1990)
15. Bausback HH and Ward PE: Kallidin and bradykinin metabolism by isolated cerebral microvessels. Biochem Pharmacol 37, 2973-2978 (1988)
16. Li Q, Feenstra M, Pfaffendorf M, Eijsman L and van Zwieten PA: Comparative vasoconstrictor effects of angiotensin II, III, and IV in human isolated saphenous vein. J Cardiovasc Pharmacol 29, 451-456 (1997)
17. Li Q, Zhang J, Pfaffendorf M and van Zwieten PA: Direct positive chronotropic effects of angiotensin II and angiotensin III in pithed rats and in rat isolated atria. Br J Pharmacol 118, 1653-1658 (1996)