Synthesis of antimicrobial 2,9,10-trisubstituted-6-oxo-7,12-dihydro-chromeno[3,4-b]quinoxalines

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 24, 2006, Pages 6181-6184

  Kotharkar, Sandeep A ^a   Shinde, Devanand B ^a  

^a DR BABASAHEB AMBEDKAR MARATHWADA UNIVERSITY   (India)

Author keywords

Antimicrobial activity; Quinoxallinones

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; QUINOXALINE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; MICROORGANISM; NONHUMAN;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; BACTERIA; CHROMONES; FUNGI; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; QUINOXALINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33750805781     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.09.040     Document Type: Article

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13. 6] DMSO) δ: 161, 149.2, 131, 129.1, 128.1, 127, 126.2, 125.2, 124.1
14. 6 One hundred microliters of 24 h growth of each microorganism was spread on the surface of nutrient agar for bacteria (Mac Conkey's agar for Escherichia coli) and potato dextrose agar for fungi, in Petri plates. Fifty microliter compounds at the concentration of 100 μg/ml in DMSO saturated on discs of 6 mm diameter were kept on agar surface. The plates were refrigerated for 2 h to allow pre-diffusion of the compounds from the discs into the seeded agar layer and then incubated at 37 °C for 24 h for bacteria and 28 °C for 48 h for fungi. Zones of inhibition were measured in millimeter and size of the disc was subtracted from the zone size to measure final activity. DMSO saturated disc served as solvent control or negative control and Streptomycin saturated discs (30 μg) for bacteria and Nystatin (30 μg) for fungi as reference or positive control.