Recognition elements that determine affinity and sequence-specific binding to DNA of 2QN, a biosynthetic bis-quinoline analogue of echinomycin

Anti-Cancer Drug Design

Volumn 14, Issue 3, 1999, Pages 291-303

  Bailly, Christian ^a   Echepare, Susana ^b   Gago, Federico ^b   Waring, Michael J ^c  

^a INSERM   (France)

^b UNIVERSITY OF ALCALÁ   (Spain)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

2QN; DNA binding; Echinomycin; Footprinting; Minor groove recognition; Molecular modelling; Quinoxaline antibiotics; Sequence specificity

Indexed keywords

DEOXYRIBONUCLEASE I; ECHINOMYCIN; NUCLEASE; PURINE DERIVATIVE; QUINOLINE DERIVATIVE;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BINDING AFFINITY; CHROMATOPHORE; CPG ISLAND; DISSOCIATION CONSTANT; DNA FOOTPRINTING; DRUG DESIGN; DRUG DNA BINDING; MOLECULAR MODEL; MOLECULAR RECOGNITION; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STREPTOMYCES;

ANTI-BACTERIAL AGENTS; BASE PAIRING; BASE SEQUENCE; BINDING SITES; DEOXYRIBONUCLEASE I; DNA; DNA FOOTPRINTING; ECHINOMYCIN; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

STREPTOMYCES; STREPTOMYCES ECHINATUS;

EID: 0032840116     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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