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Volumn 8, Issue 11, 2006, Pages 905-916

Increases in c-Src expression level and activity do not promote the growth of human colorectal carcinoma cells in vitro and in vivo

Author keywords

c Src; Cell death; Colon cancer; Proliferation; Tet On

Indexed keywords

ARTICLE; CANCER GROWTH; CARCINOGENESIS; CARCINOMA CELL; CELL PROLIFERATION; COLORECTAL CARCINOMA; CONTROLLED STUDY; GENE ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN INDUCTION; XENOGRAFT;

EID: 33750737410     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.06475     Document Type: Article
Times cited : (22)

References (38)
  • 1
    • 0035374609 scopus 로고    scopus 로고
    • The hunting of the Src
    • Martin GS (2001). The hunting of the Src. Nat Rev Mol Cell Biol 2, 467-475.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 467-475
    • Martin, G.S.1
  • 2
    • 2942618768 scopus 로고    scopus 로고
    • A renaissance for SRC
    • Yeatman TJ (2004). A renaissance for SRC. Nat Rev Cancer 4, 470-480.
    • (2004) Nat Rev Cancer , vol.4 , pp. 470-480
    • Yeatman, T.J.1
  • 3
    • 0031439247 scopus 로고    scopus 로고
    • Cellular functions regulated by Src family kinases
    • Thomas SM and Brugge JS (1997). Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 13, 513-609.
    • (1997) Annu Rev Cell Dev Biol , vol.13 , pp. 513-609
    • Thomas, S.M.1    Brugge, J.S.2
  • 4
    • 0028958025 scopus 로고
    • Src family protein tyrosine kinases and cellular signal transduction pathways
    • Erpel Tand Courtneidge SA (1995). Src family protein tyrosine kinases and cellular signal transduction pathways. Curr Opin Cell Biol 7, 176-182.
    • (1995) Curr Opin Cell Biol , vol.7 , pp. 176-182
    • Erpel, T.1    Courtneidge, S.A.2
  • 5
    • 0037150728 scopus 로고    scopus 로고
    • Src in cancer: Deregulation and consequences for cell behaviour
    • Frame MC (2002). Src in cancer: deregulation and consequences for cell behaviour. Biochim Biophys Acta 1602, 114-130.
    • (2002) Biochim Biophys Acta , vol.1602 , pp. 114-130
    • Frame, M.C.1
  • 6
    • 0038386613 scopus 로고    scopus 로고
    • Src family kinases in tumor progression and metastasis
    • Summy JM and Gallick GE (2003). Src family kinases in tumor progression and metastasis. Cancer Metastasis Rev 22, 337-358.
    • (2003) Cancer Metastasis Rev , vol.22 , pp. 337-358
    • Summy, J.M.1    Gallick, G.E.2
  • 7
    • 2542483551 scopus 로고    scopus 로고
    • SRC in human carcinogenesis
    • Russello SV and Shore SK (2004). SRC in human carcinogenesis. Front Biosci 9, 139-144.
    • (2004) Front Biosci , vol.9 , pp. 139-144
    • Russello, S.V.1    Shore, S.K.2
  • 8
    • 0027469402 scopus 로고
    • Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer
    • Talamonti MS, Roh MS, Curley SA, and Gallick GE (1993). Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer. J Clin Invest 91, 53-60.
    • (1993) J Clin Invest , vol.91 , pp. 53-60
    • Talamonti, M.S.1    Roh, M.S.2    Curley, S.A.3    Gallick, G.E.4
  • 9
    • 0025192786 scopus 로고
    • Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis
    • Cartwright CA, Meisler AI, and Eckhart W (1990). Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis. Proc Natl Acad Sci USA 87, 558-562.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 558-562
    • Cartwright, C.A.1    Meisler, A.I.2    Eckhart, W.3
  • 10
    • 0023522557 scopus 로고
    • Analysis of pp60c-src in human colon carcinoma and normal human colon mucosal cells
    • Bolen JB, Veillette A, Schwartz AM, Deseau V, and Rosen N (1987). Analysis of pp60c-src in human colon carcinoma and normal human colon mucosal cells. Oncogene Res 1, 149-168.
    • (1987) Oncogene Res , vol.1 , pp. 149-168
    • Bolen, J.B.1    Veillette, A.2    Schwartz, A.M.3    Deseau, V.4    Rosen, N.5
  • 11
    • 6844259884 scopus 로고    scopus 로고
    • Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential
    • Mao W, Irby R, Coppola D, Fu L, Wloch M, Turner J, Yu H, Garcia R, Jove R, and Yeatman TJ (1997). Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential. Oncogene 15, 3083-3090.
    • (1997) Oncogene , vol.15 , pp. 3083-3090
    • Mao, W.1    Irby, R.2    Coppola, D.3    Fu, L.4    Wloch, M.5    Turner, J.6    Yu, H.7    Garcia, R.8    Jove, R.9    Yeatman, T.J.10
  • 12
    • 0037080135 scopus 로고    scopus 로고
    • Activation of Src kinase in primary colorectal carcinoma: An indicator of poor clinical prognosis
    • Aligayer H, Boyd DD, Heiss MM, Abdalla EK, Curley SA, and Gallick GE (2002). Activation of Src kinase in primary colorectal carcinoma: an indicator of poor clinical prognosis. Cancer 94, 344-351.
    • (2002) Cancer , vol.94 , pp. 344-351
    • Aligayer, H.1    Boyd, D.D.2    Heiss, M.M.3    Abdalla, E.K.4    Curley, S.A.5    Gallick, G.E.6
  • 14
    • 0036570080 scopus 로고    scopus 로고
    • Increased Src activity disrupts cadherin/catenin-mediated homotypic adhesion in human colon cancer and transformed rodent cells
    • Irby RB and Yeatman TJ (2002). Increased Src activity disrupts cadherin/catenin-mediated homotypic adhesion in human colon cancer and transformed rodent cells. Cancer Res 62, 2669-2674.
    • (2002) Cancer Res , vol.62 , pp. 2669-2674
    • Irby, R.B.1    Yeatman, T.J.2
  • 15
    • 0037021230 scopus 로고    scopus 로고
    • Elevated c-Src is linked to altered cell-matrix adhesion rather than proliferation in KM12C human colorectal cancer cells
    • Jones RJ, Avizienyte E, Wyke AW, Owens DW, Brunton VG, and Frame MC (2002). Elevated c-Src is linked to altered cell-matrix adhesion rather than proliferation in KM12C human colorectal cancer cells. Br J Cancer 87, 1128-1135.
    • (2002) Br J Cancer , vol.87 , pp. 1128-1135
    • Jones, R.J.1    Avizienyte, E.2    Wyke, A.W.3    Owens, D.W.4    Brunton, V.G.5    Frame, M.C.6
  • 16
    • 0035992434 scopus 로고    scopus 로고
    • Src family kinase inhibitor PP2 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis
    • Nam JS, Ino Y, Sakamoto M, and Hirohashi S (2002). Src family kinase inhibitor PP2 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis. Clin Cancer Res 8, 2430-2436.
    • (2002) Clin Cancer Res , vol.8 , pp. 2430-2436
    • Nam, J.S.1    Ino, Y.2    Sakamoto, M.3    Hirohashi, S.4
  • 18
    • 0023649625 scopus 로고
    • Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain
    • Cartwright CA, Eckhart W, Simon S, and Kaplan PL (1987). Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain. Cell 49, 83-91.
    • (1987) Cell , vol.49 , pp. 83-91
    • Cartwright, C.A.1    Eckhart, W.2    Simon, S.3    Kaplan, P.L.4
  • 19
    • 0023649672 scopus 로고
    • Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation
    • Kmiecik TE and Shalloway D (1987). Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation. Cell 49, 65-73.
    • (1987) Cell , vol.49 , pp. 65-73
    • Kmiecik, T.E.1    Shalloway, D.2
  • 20
    • 0035921792 scopus 로고    scopus 로고
    • The mechanism of cell cycle regulation by v-Src
    • Riley D, Carragher NO, Frame MC, and Wyke JA (2001). The mechanism of cell cycle regulation by v-Src. Oncogene 20, 5941-5950.
    • (2001) Oncogene , vol.20 , pp. 5941-5950
    • Riley, D.1    Carragher, N.O.2    Frame, M.C.3    Wyke, J.A.4
  • 21
    • 0031471321 scopus 로고    scopus 로고
    • Overexpression of normal c-Src in poorly metastatic human colon cancer cells enhances primary tumor growth but not metastatic potential
    • Irby R, Mao W, Coppola D, Jove R, Gamero A, Cuthbertson D, Fujita DJ, and Yeatman TJ (1997). Overexpression of normal c-Src in poorly metastatic human colon cancer cells enhances primary tumor growth but not metastatic potential. Cell Growth Differ 8, 1287-1295.
    • (1997) Cell Growth Differ , vol.8 , pp. 1287-1295
    • Irby, R.1    Mao, W.2    Coppola, D.3    Jove, R.4    Gamero, A.5    Cuthbertson, D.6    Fujita, D.J.7    Yeatman, T.J.8
  • 22
    • 0035899332 scopus 로고    scopus 로고
    • Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines
    • Gayet J, Zhou XP, Duval A, Rolland S, Hoang JM, Cottu P, and Hamelin R (2001). Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines. Oncogene 20, 5025-5032.
    • (2001) Oncogene , vol.20 , pp. 5025-5032
    • Gayet, J.1    Zhou, X.P.2    Duval, A.3    Rolland, S.4    Hoang, J.M.5    Cottu, P.6    Hamelin, R.7
  • 24
    • 0034699336 scopus 로고    scopus 로고
    • Structure and function of the C-terminal hypervariable region of K-Ras4B in plasma membrane targeting and transformation
    • Welman A, Burger MM, and Hagmann J (2000). Structure and function of the C-terminal hypervariable region of K-Ras4B in plasma membrane targeting and transformation. Oncogene 19, 4582-4591.
    • (2000) Oncogene , vol.19 , pp. 4582-4591
    • Welman, A.1    Burger, M.M.2    Hagmann, J.3
  • 25
    • 0032891889 scopus 로고    scopus 로고
    • Nucleolar segregation during apoptosis of haemopoietic stem cell line FDCP-Mix
    • Reipert S, Bennion G, Hickman JA, and Allen TD (1999). Nucleolar segregation during apoptosis of haemopoietic stem cell line FDCP-Mix. Cell Death Differ 6, 334-341.
    • (1999) Cell Death Differ , vol.6 , pp. 334-341
    • Reipert, S.1    Bennion, G.2    Hickman, J.A.3    Allen, T.D.4
  • 27
    • 33750701914 scopus 로고    scopus 로고
    • Generation of cells expressing improved doxycycline regulated reverse transcriptional transactivator rtTA2S-M2
    • Welman A, Barraclough J, and Dive C (2006). Generation of cells expressing improved doxycycline regulated reverse transcriptional transactivator rtTA2S-M2. Nat Protoc 1, 803-811.
    • (2006) Nat Protoc , vol.1 , pp. 803-811
    • Welman, A.1    Barraclough, J.2    Dive, C.3
  • 28
    • 0035808252 scopus 로고    scopus 로고
    • SRC transcriptional activation in a subset of human colon cancer cell lines
    • Dehm S, Senger MA, and Bonham K (2001). SRC transcriptional activation in a subset of human colon cancer cell lines. FEBS Lett 487, 367-371.
    • (2001) FEBS Lett , vol.487 , pp. 367-371
    • Dehm, S.1    Senger, M.A.2    Bonham, K.3
  • 29
    • 0033603453 scopus 로고    scopus 로고
    • Transcriptional induction of the urokinase receptor gene by a constitutively active Src. Requirement of an upstream motif (-152/-135) bound with Sp1
    • Allgayer H, Wang H, Gallick GE, Crabtree A, Mazar A, Jones T, Kraker AJ, and Boyd DD (1999). Transcriptional induction of the urokinase receptor gene by a constitutively active Src. Requirement of an upstream motif (-152/-135) bound with Sp1. J Biol Chem 274, 18428-18437.
    • (1999) J Biol Chem , vol.274 , pp. 18428-18437
    • Allgayer, H.1    Wang, H.2    Gallick, G.E.3    Crabtree, A.4    Mazar, A.5    Jones, T.6    Kraker, A.J.7    Boyd, D.D.8
  • 30
    • 0034693877 scopus 로고    scopus 로고
    • Role of Src expression and activation in human cancer
    • Irby RB and Yeatman TJ (2000). Role of Src expression and activation in human cancer. Oncogene 19, 5636-5642.
    • (2000) Oncogene , vol.19 , pp. 5636-5642
    • Irby, R.B.1    Yeatman, T.J.2
  • 31
    • 33645072205 scopus 로고    scopus 로고
    • Treatment for advanced tumors: SRC reclaims center stage
    • Summy JM and Gallick GE (2006). Treatment for advanced tumors: SRC reclaims center stage. Clin Cancer Res 12, 1398-1401.
    • (2006) Clin Cancer Res , vol.12 , pp. 1398-1401
    • Summy, J.M.1    Gallick, G.E.2
  • 32
    • 4043063729 scopus 로고    scopus 로고
    • Opposing effects of mutant ras oncoprotein on human fibroblast and epithelial cell proliferation: Implications for models of human tumorigenesis
    • Skinner J, Bounacer A, Bond JA, Haughton MF, deMicco C, and Wynford-Thomas D (2004). Opposing effects of mutant ras oncoprotein on human fibroblast and epithelial cell proliferation: implications for models of human tumorigenesis. Oncogene 23, 5994-5999.
    • (2004) Oncogene , vol.23 , pp. 5994-5999
    • Skinner, J.1    Bounacer, A.2    Bond, J.A.3    Haughton, M.F.4    DeMicco, C.5    Wynford-Thomas, D.6
  • 33
    • 4344646902 scopus 로고    scopus 로고
    • Species- and cell type-specific requirements for cellular transformation
    • Rangarajan A, Hong SJ, Gifford A, and Weinberg RA (2004). Species- and cell type-specific requirements for cellular transformation. Cancer Cell 6, 171-183.
    • (2004) Cancer Cell , vol.6 , pp. 171-183
    • Rangarajan, A.1    Hong, S.J.2    Gifford, A.3    Weinberg, R.A.4
  • 34
    • 0033572412 scopus 로고    scopus 로고
    • Inhibition of Src kinases by a selective tyrosine kinase inhibitor causes mitotic arrest
    • Moasser MM, Srethapakdi M, Sachar KS, Kraker AJ, and Rosen N (1999). Inhibition of Src kinases by a selective tyrosine kinase inhibitor causes mitotic arrest. Cancer Res 59, 6145-6152.
    • (1999) Cancer Res , vol.59 , pp. 6145-6152
    • Moasser, M.M.1    Srethapakdi, M.2    Sachar, K.S.3    Kraker, A.J.4    Rosen, N.5
  • 35
    • 0030970723 scopus 로고    scopus 로고
    • Decreased tumorigenicity of a human colon adenocarcinoma cell line by an antisense expression vector specific for c-Src
    • Staley CA, Parikh NU, and Gallick GE (1997). Decreased tumorigenicity of a human colon adenocarcinoma cell line by an antisense expression vector specific for c-Src. Cell Growth Differ 8, 269-274.
    • (1997) Cell Growth Differ , vol.8 , pp. 269-274
    • Staley, C.A.1    Parikh, N.U.2    Gallick, G.E.3
  • 36
    • 0028910667 scopus 로고
    • Src activity increases and Yes activity decreases during mitosis of human colon carcinoma cells
    • Park J and Cartwright CA (1995). Src activity increases and Yes activity decreases during mitosis of human colon carcinoma cells. Mol Cell Biol 15, 2374-2382.
    • (1995) Mol Cell Biol , vol.15 , pp. 2374-2382
    • Park, J.1    Cartwright, C.A.2
  • 37
    • 27844451525 scopus 로고    scopus 로고
    • Activation of cPLA2 is required for leukotriene D4-induced proliferation in colon cancer cells
    • Parhamifar L, Jeppsson B, and Sjolander A (2005). Activation of cPLA2 is required for leukotriene D4-induced proliferation in colon cancer cells. Carcinogenesis 26, 1988-1998.
    • (2005) Carcinogenesis , vol.26 , pp. 1988-1998
    • Parhamifar, L.1    Jeppsson, B.2    Sjolander, A.3
  • 38
    • 84991414027 scopus 로고    scopus 로고
    • Checking out the G(2)/M transition
    • Smits VA and Medema RH (2001). Checking out the G(2)/M transition. Biochim Biophys Acta 1519, 1-12.
    • (2001) Biochim Biophys Acta , vol.1519 , pp. 1-12
    • Smits, V.A.1    Medema, R.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.