HPLC quantification of the HIV-1 protease inhibitor saquinavir in brain and testis of mice

Biomedical Chromatography

Volumn 20, Issue 10, 2006, Pages 1028-1032

  Mudigonda, Koteshwara ^a   Jukanti, Raju ^a   Apte, Shashank S ^a   Ajjala, Devender R ^b   Shrivastava, Wishu ^b   Kandikere, Vishwottam N ^b   Nirogi, Ramakrishna V S ^b  

^a KAKATIYA UNIVERSITY   (India)

^b SUVEN LIFE SCIENCES LTD   (India)

Author keywords

Brains; HPLC; Saquinavir; Testis

Indexed keywords

DRUG DELIVERY; LIQUID CHROMATOGRAPHY; TISSUE;

HIV-1 PROTEASE INHIBITORS; HPLC; HPLC METHOD; INTERNAL STANDARDS; LIQUID-LIQUID EXTRACTION PROCEDURE; MOUSE BRAIN; SAQUINAVIR; TESTIS; TISSUE MATRIX; UV DETECTION;

MAMMALS;

SAQUINAVIR; SILDENAFIL;

ACCURACY; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG TISSUE LEVEL; LIQUID LIQUID EXTRACTION; MALE; MOUSE; NONHUMAN; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SENSITIVITY AND SPECIFICITY; ULTRAVIOLET RADIATION; VALIDATION PROCESS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33750714425     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.631     Document Type: Article

References (22)

1. Aamnoutse RE, Verweij-van Wissen CP, Underberg WJ, Kleinnijenhuis J, Hekster YA and Burger DM. High-performance liquid chromatography of HIV protease inhibitors in human biological matrices. Journal of Chromatography B 2001; 764: 363.
2. Boner PL, Liu DD, Feely WF, Robinson RA and Wu J. Determination of flunixin in edible bovine tissues using liquid chromatography coupled with tandem mass spectrometry. Journal of Agricultural and Food Chemistry 2003; 51:7555.
3. Cordon-Cardo C, O'Brien JP, Casals D, Rittman-Grauer L, Biedler JL, Melamed MR and Bertino JR. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proceedings of the National Academy of Sciences of the United States of America 1989; 86: 695.
4. Chi J, Jayewardene AL, Stone JA, Motoya T and Aweeka FT. Simultaneous determination of five HIV protease inhibitors nelfinavir, indinavir, ritonavir, saquinavir and amprenavir in human plasma by LC/MS/MS. Journal of Pharmaceutical and Biomedical Analysis 2002; 30: 675.
5. Choo EF, Leake B, Wandel C, Imamura H, Wood AJ, Wilkinson GR and Kim RB. Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metabolism and Disposition 2000; 28: 655.
6. Chun TW and Fauci AS. Latent reservoirs of HIV: obstacles to the eradication of virus. Proceedings of the National Academy of Sciences of the United States of America 1999; 96; 10958.
7. Crommentuyn KM, Rosing H, Nan-Offeringa LG, Hillebrand MJ, Huitema AD and Beijnen JH. Rapid quantification of HIV protease inhibitors in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Journal of Mass Spectrometry 2003; 38: 157.
8. De Clercq E. Emerging anti-HIV drugs. Expert Opinion in Emerging Drugs 2005; 10: 241.
9. Ding Y, Williamson LN, White CA and Bartlett MG. Determination of 2′,3′-dideoxycytidine in maternal plasma, amniotic fluid, placental and fetal tissues by high-performance liquid chromatography. Journal of Chromatography B 2004; 811: 183.
10. Ha HR, Follath F, Bloemhard Y and Krahenbuhl S. Determination of saquinavir in human plasma by high-performance liquid chromatography. Journal of Chromatography B 1997; 694: 427.
11. Hoetelmans RM, van Essenberg M, Meenhorst PL, Mulder JW and Beijnen JH. Determination of saquinavir in human plasma, saliva, and cerebrospinal fluid by ion-pair high-performance liquid chromatography with ultraviolet detection. Journal of Chromatography B 1997; 698: 235.
12. Hugen PW, Burger DM, de Graaff M, ter Hofstede HJ, Hoetelmans RM, Brinkman K, Meenhorst PL, Mulder JW, Koopmans PP and Hekster YA. Saliva as a specimen for monitoring compliance but not for predicting plasma concentrations in patients with HIV treated with indinavir. Therapeutic Drug Monitoring 2000; 22: 437.
13. Kepler TB and Perelson AS. Drug concentration heterogeneity facilitates the evolution of drug resistance. Proceedings of the National Academy of Sciences of the United States of America 1998; 95: 11514.
14. Kim RB, Fromm MF, Wandel C, Leake B, Wood AJ, Roden DM and Wilkinson GR. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. Journal of Clinical Investigation 1998; 101: 289.
15. Lewis JS 2nd, Terriff CM, Coulston DR and Garrison MW. Protease inhibitors: a therapeutic breakthrough for the treatment of patients with human immunodeficiency virus. Clinical Therapeutics 1997; 19: 187.
16. Murdter TE, Sperker B, Bosslet K, Fritz P and Kroemer HK. Simultaneous high-performance liquid chromatographic determination of a glucuronyl prodrug of doxorubicin, doxorubicin and its metabolites in human lung tissue. Journal of Chromatography B 1998; 709: 289.
17. Nakashima K, Kaddoumi A, Mori M, Nakashima MN, Wada M and Aboul-Enein IfY. High-performance liquid chromatographic method for the disposition of mazindol and its metabolite 2-(2-aminoethyl)-3-(p-chlorophenyl)-3-hydroxyphthalimidine in mouse brain and plasma. Analytica Chimica Acta 2004; 502: 39.
18. Pomerantz RJ. Reservoirs of human immunodeficiency virus type 1: the main obstacles to viral eradication. Clinical Infectious Diseases 2002; 34: 91.
19. Ristic S, Tasic J, Piperski V, Dacevic M, Petrovic L and Jokanovic M. HPLC determination of tiazofurin in the rat brain. Journal of Pharmaceutical and Biomedical Analysis 2003; 33: 839.
20. Sparidans RW, Hoetelmans RM and Beijnen JH. Sensitive liquid chromatographic assay for amprenavir, a human immunodeficiency virus protease inhibitor, in human plasma, cerebrospinal fluid and semen. Journal of Chromatography B 2000; 742: 185.
21. Woolf E, Au T, Haddix H and Matuszewski B. Determination of L-735 524, an human immunodeficiency virus protease inhibitor, in human plasma and urine via high-performance liquid chromatography with column switching. Journal of Chromatography A 1995; 692: 45.
22. Zhong L and Yeh KC. Determination of indinavir in human cerebrospinal fluid and plasma by solid-phase extraction and highperformance liquid chromatography with column switching. Journal of Chromatography B 1999; 734: 63.