Dithranol abolishes UCH-L1 immunoreactivity in the nerve fibers of the rat orofacial skin

Brain Research

Volumn 1121, Issue 1, 2006, Pages 216-220

  Orojan, Ivan ^a,b   Szigeti, Csaba ^c   Varszegi, Szilvia ^c   Dobo, Endre ^c   Gulya, Karoly ^c  

^a Municipal Hospital   (Hungary)

^b Regional Outpatient Health Service   (Hungary)

^c UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Dithranol; Inflammation; Nerve fiber; Protein gene product 9.5; Rat; Skin; Ubiquitin carboxyl terminal hydrolase L1

Indexed keywords

CORTICOSTEROID; DITHRANOL; UBIQUITIN CARBOXYLTERMINAL HYDROLASE L1; UBIQUITIN THIOLESTERASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NERVE FIBER; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PSORIASIS; RAT; SKIN INFLAMMATION; SKIN NERVE; STAINING; WESTERN BLOTTING;

ANIMALS; ANTHRALIN; DERMATOLOGIC AGENTS; FACE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INFLAMMATION; MALE; MODELS, ANIMAL; MOUTH; NERVE FIBERS; PSORIASIS; RATS; RATS, SPRAGUE-DAWLEY; SKIN; SOFTWARE; UBIQUITIN THIOLESTERASE;

ANIMALIA;

EID: 33750683984     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.08.088     Document Type: Article

References (32)

1. Al'Abadie M.S., Senior H., Bleehen J., and Gawkrodger S.S. Neuropeptides and general neuronal marker in psoriasis-An immunohistochemical study. Clin. Exp. Dermatol. 20 (1995) 384-389
2. Choi J., Levey A.I., Weintraub S.T., Rees H.D., Gearing M., Chin L.-S., and Li L. Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. J. Biol. Chem. 279 (2004) 13256-13264
3. Ciechanover A., Orian A., and Schwartz A.L. The ubiquitin-mediated proteolytic pathway: mode of action and clinical implications. J. Cell Biochem. Suppl. 34 (2000) 40-51
4. Doran J.F., Jackson P., Kynoch P.A., and Thompson R.J. Isolation of PGP 9.5, a new human neuron-specific protein detected by high-resolution two-dimensional electrophoresis. J. Neurochem. 40 (1983) 1542-1547
5. Evans P.C. Regulation of pro-inflammatory signalling networks by ubiquitin: identification of novel targets for anti-inflammatory drugs. Expert Rev. Mol. Med. 7 (2005) 1-19
6. Facer P., Mann D., Mathur R., Pandya S., Ladiwala U., Singhal B., Hongo J., Sinicropi D.V., Terenghi G., and Anand P. Do nerve growth factor-related mechanisms contribute to loss of cutaneous nociception in leprosy?. Pain 85 (2000) 231-238
7. Gagne B., Gelinas S., Bureau G., Lagace B., Ramassamy C., Chiasson K., Valastro B., and Martinoli M.G. Effects of estradiol, phytoestrogens, and Ginkgo biloba extracts against 1-methyl-4-phenyl-pyridine-induced oxidative stress. Endocrine 21 (2003) 89-95
8. Ge Y., Tsukatani T., Nishimura T., Furukawa M., and Miwa T. Cell death of olfactory receptor neurons in a rat with nasosinusitis infected artificially with Staphylococcus. Chem. Senses 27 (2002) 521-527
9. Hagforsen E., Nordlind K., and Michaelsson G. Skin nerve fibres and their contacts with mast cells in patients with palmoplantar pustulosis. Arch. Dermatol. Res. 292 (2000) 269-274
10. Johansson O., Han S.W., and Enhamre A. Altered cutaneous innervation in psoriatic skin as revealed by PGP 9.5 immunohistochemistry. Arch. Dermatol. Res. 283 (1991) 519-523
11. Lambelet P., Ducret F., Loliger J., Maignan J., Reichert U., and Shroot B. The relevance of secondary radicals in the mode of action of anthralin. Free Radic. Biol. Med. 9 (1990) 183-190
12. Lange R.W., Germolec D.R., Foley J.F., and Luster M.I. Antioxidants attenuate anthralin-induced skin inflammation in BALB/c mice: role of specific proinflammatory cytokines. J. Leukoc. Biol. 64 (1998) 170-176
13. Larsen C.N., Krantz B.A., and Wilkinson K.D. Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases. Biochemistry 37 (1998) 3358-3368
14. Li Z., Melandri F., Berdo I., Jansen M., Hunter L., Wright S., Valbrun D., and Figueiredo-Pereira M.E. Delta12-prostaglandin J2 inhibits the ubiquitin hydrolase UCH-L1 and elicits ubiquitin-protein aggregation without proteasome inhibition. Biochem. Biophys. Res. Comm. 319 (2004) 1171-1180
15. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
16. McBride S.R., Walker P., and Reynolds N.J. Optimizing the frequency of outpatient short-contact dithranol treatment used in combination with broadband ultraviolet B for psoriasis: a randomized, within-patient controlled trial. Br. J. Dermatol. 149 (2003) 1259-1265
17. McGill A., Frank A., Emmett N., Turnbull D.M., Birch-Machin M.A., and Reynolds N.J. The anti-psoriatic drug anthralin accumulates in keratinocyte mitochondria, dissipates mitochondrial membrane potential, and induces apoptosis through a pathway dependent on respiratory competent mitochondria. FASEB J. 19 (2005) 1012-1014
18. McGrouther D.A., and Ahmad F.S. A preliminary report: the changes in the neuropeptide containing epidermal innervation in response to inflammatory reactions elicited in human breast skin. J.R. Coll. Surg. Edinb. 43 (1998) 49-52
19. Munoz-Castaneda J.R., Muntane J., Munoz M.C., Bujalance I., Montilla P., and Tunez I. Estradiol and catecholestrogens protect against adriamycin-induced oxidative stress in erythrocytes of ovariectomized rats. Toxicol. Lett. 160 (2006) 196-203
20. Nissalo S., Hietanen J., Malmstrom M., Hukkanen M., Polak J., and Konttinen Y.T. Disorder-specific changes in innervation in oral lichen planus and lichenoid reactions. J. Oral. Pathol. Med. 29 (2000) 361-369
21. Pelissier M.A., Muller C., Hill M., and Morfin R. Protection against dextran sodium sulfate-induced colitis by dehydroepiandrosterone and 7alpha-hydroxy-dehydroepiandrosterone in the rat. Steroids 71 (2006) 240-248
22. Poli E., Lazzaretti M., Grandi D., Pozzoli C., and Coruzzi G. Morphological and functional alterations of the myenteric plexus in rats with TNBS-induced colitis. Neurochem. Res. 26 (2001) 1085-1093
23. Shroot B., and Brown C. Free radicals in skin exposed to dithranol and its derivatives. Arzneilmittelforsch 36 (1986) 1253-1255
24. Simone D.A., Nolano M., Johnson T., Wendelschafer-Crabb G., and Kennedy W.R. Intradermal injection of capsaicin in humans produces degeneration and subsequent reinnervation of epidermal nerve fibers: correlation with sensory function. J. Neurosci. 18 (1998) 8947-8959
25. Steinhoff M., Stander S., Seeliger S., Ansel J.C., Schmelz M., and Luger T. Modern aspects of cutaneous neurogenic inflammation. Arch. Dermatol. 139 (2003) 1479-1488
26. Swinkels O.Q., Prins M., Tosserams E.F., Gerritsen M.J., Van Der Valk P.G., and Van De Kerkhof P.C. The influence of a topical corticosteroid on short-contact high-dose dithranol therapy. Br. J. Dermatol. 145 (2001) 63-69
27. Swinkels O.Q., Prins M., van Vlijmen-Willems I.M., Gerritsen M.J., van der Valk P.G., and van de Kerkhof P.C. The response of uninvolved skin of patients with psoriasis to single and repeated applications of dithranol cream: an immunohistochemical assessment. Skin Pharmacol. Appl. Skin Physiol. 15 (2002) 385-392
28. Swinkels O.Q., Kucharekova M., Prins M., Gerritsen M.J., van der Valk P.G., and van de Kerkhof P.C. The effects of topical corticosteroids and a coal tar preparation on dithranol-induced irritation in patients with psoriasis. Skin Pharmacol. Appl. Skin Physiol. 16 (2003) 12-17
29. van de Kerkhof P.C., and Franssen M.E. Psoriasis of the scalp. Diagnosis and management. Am. J. Clin. Dermatol. 2 (2001) 159-165
30. van der Vleuten C.J., de Jong E.M., and van de Kerkhof P.C. Epidermal differentiation characteristics of the psoriatic plaque during short contact treatment with dithranol cream. Clin. Exp. Dermatol. 21 (1996) 409-414
31. Wilkinson K.D., Lee K.M., Deshpande S., Duerksen-Hughes P., Boss J.M., and Pohl J. The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase. Science 246 (1989) 670-673
32. Willis C.M., Britton L.E., Reiche L., and Wilkinson J.D. Reduced levels of glutathione S-transferases in patch test reactions to dithranol and sodium lauryl sulphate as demonstrated by quantitative immunocytochemistry: evidence for oxidative stress in acute irritant contact dermatitis. Eur. J. Dermatol. 11 (2001) 99-104