Sirolimus Attenuates Chronic Allograft Nephropathy in an Experimental Rat Kidney Transplantation Model

Transplantation Proceedings

Volumn 38, Issue 8, 2006, Pages 2699-2700

  Savikko, J ^a,b   von Willebrand, E ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b PÄIJÄT HÄME CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; CYCLOSPORIN A; GROWTH FACTOR; RAPAMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; CHRONIC ALLOGRAFT NEPHROPATHY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FIBROGENESIS; GRAFT SURVIVAL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; ISOGRAFT; KIDNEY ALLOGRAFT; KIDNEY FUNCTION; KIDNEY TRANSPLANTATION; LONG TERM POTENTIATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPECIES COMPARISON; THERAPY EFFECT; TISSUE SECTION; TREATMENT OUTCOME; TREATMENT RESPONSE;

ANIMALS; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; POSTOPERATIVE COMPLICATIONS; RATS; SIROLIMUS; TRANSPLANTATION, HOMOLOGOUS; TRANSPLANTATION, ISOGENEIC;

EID: 33750626715     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2006.08.009     Document Type: Article

References (6)

1. Halloran P.F., Melk A., and Barth C. Rethinking chronic allograft nephropathy: the concept of accelerated senescence. J Am Soc Nephrol 10 (1999) 167
2. Paul L.C. Chronic allograft nephropathy- a model of impaired repair from injury?. Nephrol Dial Transplant 15 (2000) 149
3. Ruiz J.C., Campistol J.M., Grinyo J.M., et al. Early cyclosporine A withdrawal in kidney-transplant recipients receiving sirolimus prevents progression of chronic pathologic allograft lesions. Transplantation 78 (2004) 1312
4. Murghia M., Jordan S., and Kahan B. The side effect profile of sirolimus: a phase I study in quiescent cyclosporine-prednisolone-treated renal transplant patients. Kidney Int 49 (1996) 209
5. Savikko J., Kallio E.A., Taskinen E., et al. The effect of acute rejection and CsA- treatment on induction of PDGF and its receptors in the development of chronic rat renal allograft rejection. Transplantation 73 (2002) 506
6. Podder H., Stepkowski S.M., Napoli K.L., et al. Pharmacokinetic interactions augment toxicities of sirolimus/cyclosporine combinations. J Am Soc Nephrol 12 (2001) 1059