Preconception counseling for women with thrombophilia

Clinical Obstetrics and Gynecology

Volumn 49, Issue 4, 2006, Pages 906-919

  Silver, Robert M ^a   Warren, Jennifer E ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Preconception counseling; Pregnancy; Thrombophilia; Thrombophilic embolism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ACETYLSALICYLIC ACID; BLOOD CLOTTING FACTOR 5 LEIDEN; ENOXAPARIN; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; PHOSPHOLIPID ANTIBODY;

ABORTION; ALLERGY; ANTICOAGULANT THERAPY; ANTIPHOSPHOLIPID SYNDROME; ANTITHROMBIN III DEFICIENCY; CLINICAL TRIAL; FETUS DEATH; FETUS WASTAGE; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL SYMPTOM; GENE MUTATION; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; HYPERCOAGULABILITY; HYPERHOMOCYSTEINEMIA; INJECTION SITE BLEEDING; INJECTION SITE CONTUSION; MASS SCREENING; MATERNAL CARE; ORAL CONTRACEPTION; OSTEOPENIA; PREECLAMPSIA; PREGNANCY OUTCOME; PRENATAL GROWTH; PROSPECTIVE STUDY; PROTEIN C DEFICIENCY; PROTEIN S DEFICIENCY; REVIEW; SOLUTIO PLACENTAE; THROMBOPHILIA; VENOUS THROMBOEMBOLISM;

FACTOR V; FEMALE; GENETIC COUNSELING; GENETIC SCREENING; HUMANS; MUTATION; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; PREGNANCY OUTCOME; PRENATAL CARE; PROTHROMBIN; THROMBOPHILIA;

EID: 33750620217     PISSN: 00099201     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.grf.0000211959.53498.a4     Document Type: Review

References (22)

1. Lockwood CJ. Inherited thrombophilias in pregnant patients: detection and treatment paradigm. Obstet Gynecol. 2002;99:333-341.
2. Gerhardt A, Scharf RE, Beckmann MW, et al. Prothrombin and factor V mutations in women with a history of thrombosis during pregnancy and the puerperium. N Engl J Med. 2000;342:374-380.
3. Robertson L, Wu O, Langhorne P, et al. Thrombophilia in pregnancy: a systematic review. Br J Haematol. 2006;132:171-196.
4. Brill-Edwards P, Ginsberg JS, Gent M, et al, Safety of withholding heparin in pregnant women with a history of venous thromboembolism. Recurrence of Clot in This Pregnancy Study Group. N Engl J Med. 2000;343:1439-1444.
5. Dizon-Townson D, Miller C, Sibai B, et al. The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus. Obstet Gynecol. 2005;106:517-524.
6. Lindqvist PG, Svensson PJ, Marsaal K, et al. Activated protein C resistance (FV:Q506) and pregnancy. Thromb Haemost. 1999;81:532-537.
7. Paidas MJ, Ku DH, Langhoff-Roos J, et al. Inherited thrombophilias and adverse pregnancy outcome: screening and management. Semin Perinatol. 2005;29:150-163.
8. Kupferminc MJ, Eldor A, Steinman N, et al. Increased frequency of genetic thrombophilia in women with complications of pregnancy. N Engl J Med. 1999;340:9-13.
9. Surkan PJ, Stephansson O, Dickman PW, et al. Previous preterm and small-for-gestational-age births and the subsequent risk of stillbirth. N Engl J Med. 2004;350:777-785.
10. DiNisio M, Peters L, Middeldorp S. Anticoagulants for the treatment of recurrent pregnancy loss in women without antiphospholipid syndrome. Cochrane Database Syst Rev. 2005; CD004734.
11. Rey E, Kahn SR, David M, et al. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet. 2003;361:901-908.
12. Martinelli I, Taioli E, Cetin I, et al. Mutations in coagulation factors in women with unexplained late fetal loss. N Engl J Med. 2000;343:1015-1018.
13. Kujovich JL. Thrombophilia and pregnancy complications. Am J Obstet Gynecol. 2004;191:412-424.
14. Howley HE, Walker M, Rodger MA. A systematic review of the association between factor V Leiden or prothrombin gene variant and intrauterine growth restriction. Am J Obstet Gynecol. 2005;192:694-708.
15. Infante-Rivard C, Rivard GE, Yotov WV, et al. Absence of association of thrombophilia polymorphisms with intrauterine growth restriction. N Engl J Med. 2002;347:19-25.
16. Tulppala M, Marttunen M, Soderstrom-Anttila V, et al. Low-dose aspirin in prevention of miscarriage in women with unexplained or autoimmune related recurrent miscarriage: effect on prostacyclin and thromboxane A2 production. Hum Reprod. 1997;12:1567-1572.
17. Rai R, Backos M, Baxter N, et al. Recurrent miscarriage-an aspirin a day? Hum Reprod. 2000;15:2220-2223.
18. Frias AE Jr, Luikenaar RA, Sullivan AE, et al., Poor obstetric outcome in subsequent pregnancies in women with prior fetal death. Obstet Gynecol. 2004;104:521-526.
19. Gris JC, Mercier E, Quere I, et al. Low-molecular-weight heparin Versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder. Blood. 2004;103:3695-3699.
20. Alfirevic Z, Mousa HA, Martlew V, et al. Postnatal screening for thrombophilia in women with severe pregnancy complications. Obstet Gynecol. 2001;97:753-759.
21. Wu O, Robertson L, Twaddle S, et al. Screening for thrombophilia in high-risk situations: systematic review and cost-effectiveness analysis. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study. Health Technol Assess. 2006;10:1-110.
22. Gynecologist ACOG. Thromboembolism in Pregnacy, in Practice Bulletin no. 19. August 2000.