Alterations in neuronal transport but not blood-brain barrier transport are observed during gamma-hydroxybutyrate (GHB) sedative/hypnotic tolerance

Pharmaceutical Research

Volumn 23, Issue 9, 2006, Pages 2067-2077

  Bhattacharya, Indranil ^a   Raybon, Joseph J ^a   Boje, Kathleen M K ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

GABA transport; Gamma hydroxybutyric acid; Membrane fluidity; Pharmacokinetics; Tolerance

Indexed keywords

4 AMINOBUTYRIC ACID; HYPNOTIC SEDATIVE AGENT; INTRAVENOUS ANESTHETIC AGENT; OXYBATE SODIUM;

ANIMAL; AREA UNDER THE CURVE; ARTICLE; BINDING COMPETITION; BLOOD BRAIN BARRIER; BODY EQUILIBRIUM; DRUG EFFECT; DRUG TOLERANCE; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MEMBRANE FLUIDITY; METABOLISM; NERVE CELL; PERFUSION; RAT; SPRAGUE DAWLEY RAT; SYNAPTOSOME; TEMPERATURE; TRANSPORT AT THE CELLULAR LEVEL;

ANESTHETICS, INTRAVENOUS; ANIMALS; AREA UNDER CURVE; BINDING, COMPETITIVE; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CHROMATOGRAPHY, LIQUID; DRUG TOLERANCE; GAMMA-AMINOBUTYRIC ACID; HYPNOTICS AND SEDATIVES; MALE; MASS SPECTROMETRY; MEMBRANE FLUIDITY; MUSCULOSKELETAL EQUILIBRIUM; NEURONS; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY; SODIUM OXYBATE; SYNAPTOSOMES; TEMPERATURE;

EID: 33750603138     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-9066-6     Document Type: Article

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