Pharmacokinetics of the calcium-channel blocker diltiazem after a single intravenous dose in horses

Journal of Veterinary Pharmacology and Therapeutics

Volumn 29, Issue 3, 2006, Pages 165-171

  Schwarzwald, C C ^a   Sams, R A ^a   Bonagura, J D ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; CALCIUM CHANNEL BLOCKING AGENT; DEACETYLDILTIAZEM; DILTIAZEM; DRUG METABOLITE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; COMPARTMENT MODEL; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORSE; MALE; MEAN RESIDENCE TIME; NONHUMAN; NONLINEAR SYSTEM; PRIORITY JOURNAL; REGRESSION ANALYSIS; STEADY STATE; TIME; VENOUS BLOOD;

ANIMALS; AREA UNDER CURVE; CALCIUM CHANNEL BLOCKERS; DILTIAZEM; DRUG ADMINISTRATION SCHEDULE; FEMALE; HORSES; INFUSIONS, INTRAVENOUS; MALE;

ANIMALIA; CANIS FAMILIARIS; EQUIDAE; EQUUS CABALLUS;

EID: 33646240068     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2006.00733.x     Document Type: Article

References (29)

1. Clozel J.P. Billette J. Caille G. Theroux P. Cartier R. 1984 Effects of diltiazem on atrioventricular conduction and arterial blood pressure: correlation with plasma drug concentrations Canadian Journal of Physiology and Pharmacology 62 1479 1486
2. Collatos C. 1995 Update on equine therapeutics - treating atrial fibrillation in horses Compendium on Continuing Education for the Practicing Veterinarian 17 243 245
3. Cooke K.L. Snyder P.S. 1998 Calcium channel blockers in veterinary medicine Journal of Veterinary Internal Medicine 12 123 131
4. Dias V.C. Weir S.J. Ellenbogen K.A. 1992 Pharmacokinetics and pharmacodynamics of intravenous diltiazem in patients with atrial fibrillation or atrial flutter Circulation 86 1421 1428
5. Dyke T.M. Hubbell J.A. Sams R.A. Hinchcliff K.W. 1998a Hepatic blood flow in horses during the recuperative period from maximal exercise American Journal of Veterinary Research 59 1476 1480
6. Dyke T.M. Sams R.A. Hinchcliff K.W. 1998b Intensity-dependent effects of acute submaximal exercise on the pharmacokinetics of bromsulphalein in horses American Journal of Veterinary Research 59 1481 1487
7. Edoute Y. Nagachandran P. Svirski B. Ben-Ami H. 2000 Cardiovascular adverse drug reaction associated with combined beta-adrenergic and calcium entry-blocking agents Journal of Cardiovascular Pharmacology 35 556 559
8. Gelzer A.R.M. Moise N.S. Vaidya D. Wagner K.A. Jalife J. 2000 Temporal organization of atrial activity and irregular ventricular rhythm during spontaneous atrial fibrillation: an in vivo study in the horse Journal of Cardiovascular Electrophysiology 11 773 784
9. Giasson S. Garceau D. Homsy W. Dumont L. 1995 Pharmacodynamics and pharmacokinetics of clentiazem and diltiazem in closed-chest anesthetized dogs Cardiovascular Drugs and Therapy 9 685 692
10. Gibaldi M. Perrier D. 1975 Multicompartment models In Pharmacokinetics Eds Gibaldi M. Perrier D. pp 45 96 Marcel Dekker, Inc. New York, USA
11. Hamann S.R. McAllister R.G. 1994 Cardiodepressant actions of combined diltiazem and propranolol in dogs Journal of Cardiovascular Pharmacology 23 31 36
12. Hermann P. Morselli P.L. 1985 Pharmacokinetics of diltiazem and other calcium entry blockers Acta Pharmacologica et Toxicologica 57 Suppl. 2 10 20
13. Kohno K. Takeuchi Y. Etoh A. Noda K. 1977 Pharmacokinetics and bioavailability of diltiazem (CRD-401) in dogs Arzneimittel-forschung 27 1424 1428
14. Laganiere S. Davies R.F. Carignan G. Foris K. Goernert L. Carrier K. Pereira C. McGilveray I. 1996 Pharmacokinetic and pharmacodynamic interactions between diltiazem and quinidine Clinical Pharmacology and Therapeutics 60 255 264
15. McAllister R.G. Jr. Hamann S.R. Blouin R.A. 1985 Pharmacokinetics of calcium-entry blockers American Journal of Cardiology 55 30B 40B
16. Miyamoto M. Nishijima Y. Nakayama T. Hamlin R.L. 2000 Cardiovascular effects of intravenous diltiazem in dogs with iatrogenic atrial fibrillation Journal of Veterinary Internal Medicine 14 445 451
17. Moise N.S. 1999 Diagnosis and management of canine arrhythmias In Textbook of Canine and Feline Cardiology Eds Fox P.R. Sisson D. Moïse N.S. pp 331 385 WB Saunders Company Philadelphia, USA
18. Nappi J.M. Mason J.W. 1996 Quinidine In Cardiovascular Drug Therapy Ed Messerli F.H. pp 1362 1369 WB Saunders Company Philadelphia, USA
19. Opie L.H. 2001 Calcium channel blockers (calcium antagonists) In Drugs for the Heart Eds Opie L.H. Gersh B.J. pp 53 83 W. B. Saunders Company Philadelphia, USA
20. Opie L.H. Gersh B.J. 2001 Digitalis, acute inotropes, and inotropic dilators In Drugs for the Heart Eds Opie L.H. Gersh B.J. pp 154 186 WB Saunders Company Philadelphia, USA
21. Piepho R.W. Bloedow D.C. Lacz J.P. Runser D.J. Dimmit D.C. Browne R.K. 1982 Pharmacokinetics of diltiazem in selected animal species and human beings American Journal of Cardiology 49 525 528
22. Pool P.E. 1996 Diltiazem In Cardiovascular Drug Therapy Ed Messerli F.H. pp 931 971 WB Saunders Company Philadelphia, USA
23. Reef V.B. Reimer J.M. Spencer P.A. 1995 Treatment of atrial fibrillation in horses: new perspectives Journal of Veterinary Internal Medicine 9 57 67
24. Schwarzwald C.C. Bonagura J.D. Luis-Fuentes V. 2005 Effects of diltiazem on hemodynamic variables and ventricular function in healthy horses Journal of Veterinary Internal Medicine 19 703 711
25. Shargel L. Yu A.B.C. 1999 Applied Biopharmaceutics and Pharmacokinetics McGraw-Hill New York, USA
26. Smith M.S. Verghese C.P. Shand D.G. Pritchett E.L. 1983 Pharmacokinetic and pharmacodynamic effects of diltiazem American Journal of Cardiology 51 1369 1374
27. Talajic M. Nattel S. 1986 Frequency-dependent effects of calcium antagonists on atrioventricular conduction and refractoriness: demonstration and characterization in anesthetized dogs Circulation 74 1156 1167
28. Toutain P.L. Bousquet-Melou A. 2004 Plasma clearance Journal of Veterinary Pharmacology and Therapeutics 27 415 425
29. Yeung P.K. Mosher S.J. Quilliam M.A. Montague T.J. 1990 Species comparison of pharmacokinetics and metabolism of diltiazem in humans, dogs, rabbits, and rats Drug Metabolism and Disposition 18 1055 1059