Apoptotic activity of a novel synthetic cantharidin analogue on hepatoma cell lines

International Journal of Molecular Medicine

Volumn 17, Issue 5, 2006, Pages 945-949

  Kok, Stanton Hon Lung ^a   Chui, Chung Hin ^a,b   Lam, Wing Sze ^a   Chen, Jien ^a   Lau, Fung Yi ^b   Cheng, Gregory Yin Ming ^b   Wong, Raymond Siu Ming ^b   Lai, Paul Po San ^b   Leung, Thomas Wai Tong ^c   Tang, Johnny Cheuk On ^a   Chan, Albert Sun Chi ^a  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c HONG KONG SANATORIUM AND HOSPITAL   (Hong Kong)

Author keywords

Apoptosis; Cantharidin; Hepatoma

Indexed keywords

ANTINEOPLASTIC AGENT; CAN 032; CANTHARIDIN; DNA FRAGMENT; DRUG DERIVATIVE; THIAZOLE DERIVATIVE;

ADULT; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL CYCLE; CELL SIZE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; FEMALE; GENETICS; HUMAN; LIVER CELL CARCINOMA; MALE; PATHOLOGY; PATHOPHYSIOLOGY; PHASE CONTRAST MICROSCOPY; SYNTHESIS; TUMOR CELL LINE;

ADULT; ANTINEOPLASTIC AGENTS; APOPTOSIS; BONE MARROW CELLS; CANTHARIDIN; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL LINE, TUMOR; CELL SIZE; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MICROSCOPY, PHASE-CONTRAST; MOLECULAR STRUCTURE; THIAZOLES;

EID: 33750586978     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.17.5.945     Document Type: Article

References (17)

1. Leung TWT, Patt YZ, Lau WY, Ho SKW, Yu SC, Chan ATC, Mok TSK, Yeo W, Liew CT, Leung NW, Tang AMY and Johnson PJ: Complete pathological remission is possible with systemic combination chemotherapy for inoperable hepatocellular carcinoma. Clin Cancer Res 5: 1676-1681, 1999.
2. Tsauer W, Lin JG, Lin PY, Hsu FL and Chiang HC: The effects of cantharidin analogues on xanthine oxidase. Anticancer Res 17: 2095-2098, 1997.
3. Zhang S: A study on antitumor chemotherapeutic agents: synthesis of N-cantharidine derivatives. Yao Xue Xue Bao 16: 784-786, 1981.
4. Kok SHL, Chui CH, Lam WS, Cheng J, Tang JCO, Lau FY, Cheng GYM, Wong RSM and Chan ASC: Induction of apoptosis on carcinoma cells by two synthetic cantharidin analogues. Int J Mol Med 17: 151-157, 2006.
5. Chow LMC, Chui CH, Tang JCO, Teo I, Lau FY, Cheng GYM, Wong RSM, Leung TWT, Lai KB, Yau M, Gou D and Chan ASC: Gleditsia sinensis fruit extract is a potential chemotherapeutic agent in chronic and acute myelogenous leukemia. Oncol Rep 10: 1601-1607, 2003.
6. Lau FY, Chui CH, Gambari R, Kok SHL, Kan KL, Cheng GYM, Wong RSM, Teo ITN, Cheng CH, Wan TSK, Chan ASC and Tang JCO: Antiproliferative and apoptosis-inducing activity of Brucea javanica extract on human carcinoma cells. Int J Mol Med 16: 1157-1162, 2005.
7. Chow LMC, Chui CH, Tang JCO, Lau FY, Yau MYC, Cheng GYM, Wong RSM, Lai PBS, Leung TWT, Teo ITN, Cheung F, Guo D and Chan ASC: Anti-angiogenic potential of Gleditsia sinensis fruit extract. Int J Mol Med 12: 269-273, 2003.
8. Chui CH, Cheng GYM, Ke B, Lau FY, Wong RSM, Kok SHL, Fatima S, Cheung F, Cheng CH, Chan ASC and Tang JCO: Growth inhibitory potential of effective microorganism fermentation extract (EM-X) on cancer cells. Int J Mol Med 14: 925-929, 2004.
9. Cheung F, Chui CH, Chan ASC, Lau FY, Cheng GYM, Wong RSM, Kok SHL, Teo ITN, Cheng CH and Tang JCO: Inhibition of proteasome activity in Gleditsia sinensis fruit extract-mediated apoptosis on human carcinoma cells. Int J Mol Med 16: 925-929, 2005.
10. Teo ITN, Chui CH, Tang JCO, Lau FY, Cheng GYM, Wong RSM, Kok SHL, Cheng CH, Chan ASC and Ho KP: Antiproliferation and induction of cell death of Phaffia rhodozyma extract fermented by brewer malt waste on breast cancer cells. Int J Mol Med 16: 931-936, 2005.
11. Chui CH, Lau FY, Tang JCO, Kam KL, Cheng GYM, Wong RSM, Kok SHL, Lai PBS, Ho R, Gambari R and Chan ASC: Activities of fresh juice of Scutellaria barbata and warmed water extract of Radix Sophorae Tonkinensis on antiproliferation and apoptosis of human cancer cell lines. Int J Mol Med 16: 337-341, 2005.
12. Chow LMC, Tang JCO, Teo ITN, Chui CH, Lau FY, Leung TWT, Cheng G, Wong RSM, Wong ILK, Tsang KMS, Tan WQ, Zhao YZ, Lai KB, Lam WH, Guo DA and Chan ASC: Antiproliferative activity of the extract of Gleditsia sinensis fruit on human solid tumour cell lines. Chemotherapy 48: 303-308, 2002.
13. Chui CH, Lau FY, Chan ASC, Cheng GYM, Wong RSM, Lai KB, Kok SHL, Au Yeung TTL, Teo ITN, Yau MYC, Cheung F, Cheng CH and Tang JCO: Gleditsia sinensis fruit extract-induced apoptosis involves changes of reactive oxygen species level, mitochondrial membrane depolarization and caspase 3 activation. Int J Mol Med 15: 539-543, 2005.
14. Chui CH, Gambari R, Lau FY, Teo ITN, Ho KP, Cheng GYM, Ke B, Higa T, Kok HL, Chan ACS and Tang JCO: Anti-cancer potential of traditional Chinese herbal medicines and microbial fermentation products. Minerva Biotec 17: 183-191, 2005.
15. Yang NS, Shyur LF, Chen CH, Wang SY and Tzeng CM: Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in MCF-7 cells. J Biomed Sci 11: 418-422, 2004.
16. Harris CC: Hepatocellular carcinogenesis: recent advances and speculation. Cancer Cells 2: 146-148, 1990.
17. Okuda K: Hepatocellular carcinoma: recent progress. Hepatology 15: 948-963, 1992.