Gleditsia sinensis fruit extract is a potential chemotherapeutic agent in chronic and acute myelogenous leukemia

Oncology Reports

Volumn 10, Issue 5, 2003, Pages 1601-1607

  Chow, Larry Ming Cheung ^a   Chui, Chung Hin ^a,b   Tang, Johnny Cheuk On ^a   Teo, Ivy Tuang Ngo ^a   Lau, Fung Yi ^b   Cheng, Gregory Yin Ming ^b   Wong, Raymond Seu Ming ^b   Leung, Thomas Wai Tong ^b   Lai, Ka Bik ^b   Yau, Mabel Yin Chun ^a   Gou, Dean ^c   Chan, Albert Sun Chi ^a  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c PEKING UNIVERSITY   (China)

Author keywords

Apoptosis; in vitro; Traditional Chinese medicine

Indexed keywords

DNA FRAGMENT; PLANT EXTRACT; PLANT MEDICINAL PRODUCT;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ARTICLE; BONE MARROW; CELL CYCLE G1 PHASE; CELL DEATH; CELL DIVISION; CELL STRAIN HL 60; CELL STRAIN K 562; CHEMICAL MODEL; CHRONIC MYELOID LEUKEMIA; CLONOGENIC ASSAY; DOSE RESPONSE; FEMALE; FLOW CYTOMETRY; GLEDITSIA; HUMAN; MALE; METABOLISM; MIDDLE AGED; NICK END LABELING; PHYTOTHERAPY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME;

ADULT; BONE MARROW; CELL DEATH; CELL DIVISION; COLONY-FORMING UNITS ASSAY; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLOW CYTOMETRY; G1 PHASE; GLEDITSIA; HL-60 CELLS; HUMANS; IN SITU NICK-END LABELING; K562 CELLS; LEUKEMIA, MYELOCYTIC, ACUTE; LEUKEMIA, MYELOID, CHRONIC; MALE; MIDDLE AGED; MODELS, CHEMICAL; PHYTOTHERAPY; PLANT EXTRACTS; PLANT PREPARATIONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS;

EID: 2142742816     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.10.5.1601     Document Type: Article

References (22)

1. Staba EJ: Ginseng. Lancet 7: 1309-1310, 1985.
2. Kakizoe T: Asian studies of cancer chemoprevention: last clinical results. Eur J Cancer 36: 1303-1309, 2000.
3. Shin HR, Kim JY, Yun TK, Morgan G and Vainio H: The cancer-preventive potential of Panax ginseng: a review of human and experimental evidence. Cancer Causes Control 11: 565-576, 2000. (Pubitemid 30342846)
4. Konoshima T, Takasaki M, Ichiishi E, Murakami T, Tokuda H, Nishino H, Due NM, Kasai R and Yamasaki K: Cancer chemopreventive activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis. Cancer Lett 147: 11-16, 1999.
5. Klepser TB and Klepser ME: Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 56: 125-138, 1999. (Pubitemid 29052733)
6. Baek NI, Kim DS, Lee YH, Park JD, Lee CB and Kim SI: Cytotoxicity of ginseng saponins and their degradation products against some cancer cell lines. Arch Pharm Res 18: 164-168, 1995.
7. Kitagawa I, Yoshikawa M, Yoshihara M, Hayashi T and Toniyama T: Chemical studies on crude drug precession. I. On the constituents of Ginseng Radix Ruba. Yakugaku Zasshi 103: 612-622, 1983. (Pubitemid 13027064)
8. Ota T, Fujikawa-Yamamoto K, Zong ZP, Yamazaki M, Odashima S, Kitagawa I, Abe H and Arichi S: Plant glycoside modulation of cell surface related to control of differentiation in cultured B16 melanoma cells. Cancer Res 47: 3863-3867, 1987. (Pubitemid 17105740)
9. Ota T, Maeda M and Odashima S: Mechanism of action of Ginsenoside-h2; uptake and metabolism of Ginsenoside-Rh2 by cultured B-16 melanoma cells. J Pharm Sci 80: 1141-1146, 1991.
10. Liu WK, Xu SX and Che CT: Anti-proliferative effect of ginseng saponins on human prostate cancer cell line. Life Sci 67: 1297-1306, 2000. (Pubitemid 30640817)
11. Ren WP and Tang DG: Extract of Solanum Muricatum (Pepino/CSG) inhibits tumor growth by inducing apoptosis. Anticancer Res 19: 403-408, 1999.
12. Huynh HT and Teel RW: Selective induction of apoptosis in human mammary cancer cells (MCF-7) by Pycnogenol. Anticancer Res 20: 2417-2420, 2000. (Pubitemid 30614445)
13. Jiangsu New Medical College. In: Zhong Yao Da Ci Dian. Shanghai People's Public Health Publishing House, Shanghai, pp2198, 1977.
14. Zhang Z, Koike K, Jia Z, Nikaido T, Guo D and Zheng, J: Four new triterpenoidal saponins acylated with one monoterpenic acid from Gleditsia siensis. J Nat Prod 62: 740-745, 1999. (Pubitemid 29259093)
15. Strobel T, Swanson L, Korsmeyer S and Cannistra SA: BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway. Proc Natl Acad Sci USA 93: 14094-14099, 1996. (Pubitemid 26424251)
16. Tang C, Willingham MC, Reed JC, Miyashita T, Ray S, Ponnathpur V, Huang Y, Mahoney ME, Bullock G and Bhalla K: High levels of p26BCL-2 oncoprotein retard Taxol-induced apoptosis in human pre-B leukemia cells. Leukemia 8: 1960-1969, 1994.
17. Sung MK, Kendall CWC, Koo MM and Rao AV: Effect of soybean saponins and gypsophilla saponin on growth and viability of colon carcinoma cells in culture. Nutr Cancer 23: 259-270, 1995.
18. 2 production by peritoneal macrophages. Planta Med 51: 208-212, 1985.
19. Hsu MJ, Cheung JS and Huang HC: Effect of saikosaponin, a triterpene saponin, on apoptosis in lymphocytes: association with c-myc, p53, and bcl-2 mRNA. Br J Pharmacol 131: 1285-1293, 2000.
20. Chow LMC, Tang JCO, Teo ITN, Chui CH, Lau FY, Leung TWT, Cheng G, Wong RSM, Wong ILK, Tsang KMS, ZhaoYZ, Tan WQ, Lai KB, Lam WH, Guo DA and Chan ASC: The antiproliferative activity of extract from Gleditsia sinensis fruit on human solid tumour cell lines. Chemotherapy (In press).
21. Kim SE, Lee YH, Park JH and Lee SK: Ginsenoside-RS4, a new type of ginseng saponin concurrently induces apoptosis and selectively elevates protein levels of p53 and p21WAF1 in human hepatoma. Eur J Cancer 35: 507-511, 1999. (Pubitemid 29151953)
22. Lee SJ, Sung JH, Lee SJ, Moon CK and Lee BH: Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma resistant to cisplatin. Cancer Lett 144: 39-43, 1999.