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Volumn 29, Issue 6, 2006, Pages 477-488

Pharmacodynamic effects and pharmacokinetic profile of a long-term continuous rate infusion of racemic ketamine in healthy conscious horses

Author keywords

[No Author keywords available]

Indexed keywords

5,6 DEHYDRONORKETAMINE; DRUG METABOLITE; ENZYME; FATTY ACID; GLUCOSE; HYDROCORTISONE; HYDROXYNORKETAMINE; INSULIN; KETAMINE; LACTIC ACID; NARKETAN; NORKETAMINE; UNCLASSIFIED DRUG;

EID: 33750582242     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2006.00794.x     Document Type: Article
Times cited : (58)

References (53)
  • 2
    • 0019403610 scopus 로고
    • Conversational SAAM - An interactive program for kinetic analysis of biological systems
    • Boston, R.C., Greif, P.C. & Berman, M. (1981) Conversational SAAM - an interactive program for kinetic analysis of biological systems. Computer Methods and Programs in Biomedicine, 13, 111-119.
    • (1981) Computer Methods and Programs in Biomedicine , vol.13 , pp. 111-119
    • Boston, R.C.1    Greif, P.C.2    Berman, M.3
  • 3
    • 0036263604 scopus 로고    scopus 로고
    • Ketamine, an N-methyl-D-aspartate receptor antagonist, inhibits the reflex responses to distension of the rat urinary bladder
    • Castroman, P.J. & Ness, T.J. (2002a) Ketamine, an N-methyl-D-aspartate receptor antagonist, inhibits the reflex responses to distension of the rat urinary bladder. Anesthesiology, 96, 1401-1409.
    • (2002) Anesthesiology , vol.96 , pp. 1401-1409
    • Castroman, P.J.1    Ness, T.J.2
  • 4
    • 0036260332 scopus 로고    scopus 로고
    • Ketamine, an N-methyl-D-aspartate receptor antagonist, inhibits the spinal neuronal responses to distension of the rat urinary bladder
    • Castroman, P.J. & Ness, T.J. (2002b) Ketamine, an N-methyl-D-aspartate receptor antagonist, inhibits the spinal neuronal responses to distension of the rat urinary bladder. Anesthesiology, 96, 1410-1419.
    • (2002) Anesthesiology , vol.96 , pp. 1410-1419
    • Castroman, P.J.1    Ness, T.J.2
  • 5
    • 0027477465 scopus 로고
    • Contribution of central neuroplasticity to pathological pain: Review of clinical and experimental evidence
    • Coderre, T.J., Katz, J., Vaccarinou, A.L. & Melzack, R. (1993) Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain, 52, 259-285.
    • (1993) Pain , vol.52 , pp. 259-285
    • Coderre, T.J.1    Katz, J.2    Vaccarinou, A.L.3    Melzack, R.4
  • 7
    • 0020042852 scopus 로고
    • Plasma levels of ketamine and two of its metabolites in surgical patients using a gas chromatographic mass fragmentaographic assay
    • Domino, E.F., Zsigmond, E.K., Domino, L.E., Domino, K.E., Kothary, S.P. & Domino, S.E. (1982) Plasma levels of ketamine and two of its metabolites in surgical patients using a gas chromatographic mass fragmentaographic assay. Anesthesia Analgesia, 61, 87-92.
    • (1982) Anesthesia Analgesia , vol.61 , pp. 87-92
    • Domino, E.F.1    Zsigmond, E.K.2    Domino, L.E.3    Domino, K.E.4    Kothary, S.P.5    Domino, S.E.6
  • 8
    • 0035860356 scopus 로고    scopus 로고
    • Tissue uptake of ketamine and norketamine enantiomers in the rat - Indirect evidence for extrahepatic metabolic inversion
    • Edwards, S.R. & Mather, L.E. (2001) Tissue uptake of ketamine and norketamine enantiomers in the rat - indirect evidence for extrahepatic metabolic inversion. Life Sciences, 69, 2051-2066.
    • (2001) Life Sciences , vol.69 , pp. 2051-2066
    • Edwards, S.R.1    Mather, L.E.2
  • 9
    • 0036138838 scopus 로고    scopus 로고
    • Concurrent ketamine and alfentanil administration: Pharmacokinetic considerations
    • Edwards, S.R., Minto, C.F. & Mather, L.E. (2002) Concurrent ketamine and alfentanil administration: pharmacokinetic considerations. British Journal of Anaesthesia, 88, 94-100.
    • (2002) British Journal of Anaesthesia , vol.88 , pp. 94-100
    • Edwards, S.R.1    Minto, C.F.2    Mather, L.E.3
  • 10
    • 0033794460 scopus 로고    scopus 로고
    • Targeting the N-methyl-D-aspartate receptor for chronic pain management. Preclinical animal studies, recent clinical experience and future research directions
    • Fisher, K., Coderre, T.J. & Hagen, N. (2000) Targeting the N-methyl-D-aspartate receptor for chronic pain management. Preclinical animal studies, recent clinical experience and future research directions. Journal of Pain and Symptom Management, 20, 358-373.
    • (2000) Journal of Pain and Symptom Management , vol.20 , pp. 358-373
    • Fisher, K.1    Coderre, T.J.2    Hagen, N.3
  • 11
    • 0027288890 scopus 로고
    • Pharmacokinetics and pharmacodynamics of ketamine enantiomers in surgical patients using a stereoselective analytical method
    • Geisslinger, G., Hering, W., Thomann, P., Knoll, R., Kamp, H.-D. & Brine, K. (1993) Pharmacokinetics and pharmacodynamics of ketamine enantiomers in surgical patients using a stereoselective analytical method. British Journal of Anaesthesia, 70, 666-671.
    • (1993) British Journal of Anaesthesia , vol.70 , pp. 666-671
    • Geisslinger, G.1    Hering, W.2    Thomann, P.3    Knoll, R.4    Kamp, H.-D.5    Brine, K.6
  • 14
    • 0033951931 scopus 로고    scopus 로고
    • The effects of ketamine on the temporal summation (wind-up) of the R(III) nociceptive flexion reflex and pain in humans
    • Guirimand, F., Dupont, X., Brasseur, L., Chauvin, M. & Bouhassira, D. (2000) The effects of ketamine on the temporal summation (wind-up) of the R(III) nociceptive flexion reflex and pain in humans. Anesthesia Analgesia, 90, 408-414.
    • (2000) Anesthesia Analgesia , vol.90 , pp. 408-414
    • Guirimand, F.1    Dupont, X.2    Brasseur, L.3    Chauvin, M.4    Bouhassira, D.5
  • 15
    • 0034866570 scopus 로고    scopus 로고
    • Stability of ketamine and its metabolites norketamine and dehydronorketamine in human biological samples
    • Hijazi, Y., Bolon, M. & Boulieu, R. (2001) Stability of ketamine and its metabolites norketamine and dehydronorketamine in human biological samples. Clinical Chemistry, 47, 1713-1715.
    • (2001) Clinical Chemistry , vol.47 , pp. 1713-1715
    • Hijazi, Y.1    Bolon, M.2    Boulieu, R.3
  • 16
    • 0344851901 scopus 로고    scopus 로고
    • Ketamine in chronic pain management: An evidence-based review
    • Hocking, G. & Cousins, M.J. (2003) Ketamine in chronic pain management: an evidence-based review. Anesthesia Analgesia, 97, 1730-1739.
    • (2003) Anesthesia Analgesia , vol.97 , pp. 1730-1739
    • Hocking, G.1    Cousins, M.J.2
  • 17
    • 0035987178 scopus 로고    scopus 로고
    • Assessment of the effect of dextromethorphan and ketamine on the acute nociceptive threshold and wind-up of the second pain response in healthy male volunteers
    • Hughes, A.M., Rhodes, J., Fisher, G., Sellers, M. & Growcott, J.W. (2002) Assessment of the effect of dextromethorphan and ketamine on the acute nociceptive threshold and wind-up of the second pain response in healthy male volunteers. British Journal of Clinical Pharmacology, 53, 604-612.
    • (2002) British Journal of Clinical Pharmacology , vol.53 , pp. 604-612
    • Hughes, A.M.1    Rhodes, J.2    Fisher, G.3    Sellers, M.4    Growcott, J.W.5
  • 18
    • 0028406315 scopus 로고
    • Factors affecting the circadian rhythm in plasma cortisol concentrations in the horse
    • Irvine, C.H. & Alexander, S.L. (1994) Factors affecting the circadian rhythm in plasma cortisol concentrations in the horse. Domestic Animal Endocrinology, 11, 227-238.
    • (1994) Domestic Animal Endocrinology , vol.11 , pp. 227-238
    • Irvine, C.H.1    Alexander, S.L.2
  • 21
    • 0029859039 scopus 로고    scopus 로고
    • A comparison of romifidine and xylazine when used with diazepam/ketamine for short duration anesthesia in the horse
    • Kerr, C.L., McDonell, W. & Young, S.S. (1996) A comparison of romifidine and xylazine when used with diazepam/ketamine for short duration anesthesia in the horse. Canadian Veterinary Journal, 37, 601-609.
    • (1996) Canadian Veterinary Journal , vol.37 , pp. 601-609
    • Kerr, C.L.1    McDonell, W.2    Young, S.S.3
  • 22
    • 0028630784 scopus 로고
    • Ketamine suppresses tumor necrosis factor-alpha activity and mortality in carrageenan sensitized endotoxin shock model
    • Koga, K., Ogata, M., Takenaka, I., Matsumoto, T. & Shigematsu, A. (1994) Ketamine suppresses tumor necrosis factor-alpha activity and mortality in carrageenan sensitized endotoxin shock model. Circulatory Shock, 44, 160-168.
    • (1994) Circulatory Shock , vol.44 , pp. 160-168
    • Koga, K.1    Ogata, M.2    Takenaka, I.3    Matsumoto, T.4    Shigematsu, A.5
  • 23
    • 14844363424 scopus 로고    scopus 로고
    • Ketamine inhibits LPS-induced tumour necrosis factor-alpha and interleukin-6 in an equine macrophage cell line
    • Lankveld, D.P.K., Bull, S., Van Dijk, P., Fink-Gremmels, J. & Hellebrekers, L. (2005) Ketamine inhibits LPS-induced tumour necrosis factor-alpha and interleukin-6 in an equine macrophage cell line. Veterinary Research, 36, 257-262.
    • (2005) Veterinary Research , vol.36 , pp. 257-262
    • Lankveld, D.P.K.1    Bull, S.2    Van Dijk, P.3    Fink-Gremmels, J.4    Hellebrekers, L.5
  • 24
    • 0035854069 scopus 로고    scopus 로고
    • Effect of ketamine on spinal cord nociceptive transmission in normal and monoarthritic rats
    • Laurido, C., Pelissier, T., Perez, H., Flores, F. & Hernandez, A. (2001) Effect of ketamine on spinal cord nociceptive transmission in normal and monoarthritic rats. Neuroreport, 12, 1551-1554.
    • (2001) Neuroreport , vol.12 , pp. 1551-1554
    • Laurido, C.1    Pelissier, T.2    Perez, H.3    Flores, F.4    Hernandez, A.5
  • 25
    • 0017815021 scopus 로고
    • The development of tolerance to ketamine in rats and the significance of hepatic metabolism
    • Livingston, A. & Waterman, A.E. (1978) The development of tolerance to ketamine in rats and the significance of hepatic metabolism. British Journal of Pharmacology, 64, 63-69.
    • (1978) British Journal of Pharmacology , vol.64 , pp. 63-69
    • Livingston, A.1    Waterman, A.E.2
  • 28
    • 0034785689 scopus 로고    scopus 로고
    • Urine concentrations of ketamine and norketamine following illegal consumption
    • Moore, K.A., Sklerov, J., Levine, B. & Jacobs, A.J. (2001) Urine concentrations of ketamine and norketamine following illegal consumption. Journal of Analytical Toxicology, 25, 583-588.
    • (2001) Journal of Analytical Toxicology , vol.25 , pp. 583-588
    • Moore, K.A.1    Sklerov, J.2    Levine, B.3    Jacobs, A.J.4
  • 29
    • 0026862471 scopus 로고
    • Effect of experimentally induced endotoxemia on serum interleukin-6 activity in horses
    • Morris, D.D., Crowe, N. & Moldawer, L.L. (1992) Effect of experimentally induced endotoxemia on serum interleukin-6 activity in horses. American Journal of Veterinary Research, 53, 753-756.
    • (1992) American Journal of Veterinary Research , vol.53 , pp. 753-756
    • Morris, D.D.1    Crowe, N.2    Moldawer, L.L.3
  • 30
    • 0026757784 scopus 로고
    • Effects of ketamine infusion on halothane minimal alveolar concentration in horses
    • Muir, W.W. & Sams, R. (1992) Effects of ketamine infusion on halothane minimal alveolar concentration in horses. American Journal of Veterinary Research, 53, 1802-1806.
    • (1992) American Journal of Veterinary Research , vol.53 , pp. 1802-1806
    • Muir, W.W.1    Sams, R.2
  • 31
    • 0017595850 scopus 로고
    • Evaluation of xylazine and ketamine hydrochloride for anesthesia in horses
    • Muir, W.W., Skarda, R.T. & Milne, D.W. (1977) Evaluation of xylazine and ketamine hydrochloride for anesthesia in horses. American Journal of Veterinary Research, 38, 195-201.
    • (1977) American Journal of Veterinary Research , vol.38 , pp. 195-201
    • Muir, W.W.1    Skarda, R.T.2    Milne, D.W.3
  • 32
    • 0029914606 scopus 로고    scopus 로고
    • Simultaneous infusions of propofol and ketamine in ponies premedicated with detomidine: A pharmacokinetic study
    • Nolan, A., Reid, J., Welsh, E., Flaherty, D., McCormack, R. & Monteiro, A.M. (1996) Simultaneous infusions of propofol and ketamine in ponies premedicated with detomidine: a pharmacokinetic study. Research in Veterinary Science, 60, 262-266.
    • (1996) Research in Veterinary Science , vol.60 , pp. 262-266
    • Nolan, A.1    Reid, J.2    Welsh, E.3    Flaherty, D.4    McCormack, R.5    Monteiro, A.M.6
  • 33
    • 0029937786 scopus 로고    scopus 로고
    • Systemic ketamine attenuates nociceptive behaviors in a rat model of peripheral neuropathy
    • Quian, J., Brown, S.D. & Carlton, S.M. (1996) Systemic ketamine attenuates nociceptive behaviors in a rat model of peripheral neuropathy. Brain Research, 715, 51-62.
    • (1996) Brain Research , vol.715 , pp. 51-62
    • Quian, J.1    Brown, S.D.2    Carlton, S.M.3
  • 34
    • 0023127393 scopus 로고
    • Detection and identification of ketamine and its metabolites in horse urine
    • Sams, R. & Pizzo, P. (1987) Detection and identification of ketamine and its metabolites in horse urine. Journal of Analytical Toxicology, 11, 58-62.
    • (1987) Journal of Analytical Toxicology , vol.11 , pp. 58-62
    • Sams, R.1    Pizzo, P.2
  • 35
    • 0032980878 scopus 로고    scopus 로고
    • Use and efficacy of low-dose ketamine in the management of acute postoperative pain: A review of current techniques and outcomes
    • Schmid, R.L., Sandler, A.N. & Katz, J. (1999) Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes. Pain, 82, 111-125.
    • (1999) Pain , vol.82 , pp. 111-125
    • Schmid, R.L.1    Sandler, A.N.2    Katz, J.3
  • 37
    • 0027383003 scopus 로고
    • Rapid high-performance liquid chromatographic method for the determination of ketamine and its metabolite dehydronorketamine in equine serum
    • Seay, S.S., Aucoin, D.P. & Tyczkowska, K.L. (1993) Rapid high-performance liquid chromatographic method for the determination of ketamine and its metabolite dehydronorketamine in equine serum. Journal of Chromatography, 620, 281-287.
    • (1993) Journal of Chromatography , vol.620 , pp. 281-287
    • Seay, S.S.1    Aucoin, D.P.2    Tyczkowska, K.L.3
  • 38
    • 0141682425 scopus 로고    scopus 로고
    • WinSAAM: A windows-based compartmental modeling system
    • [Review] [18 refs]
    • Stefanovski, D., Moate, P.J. & Boston, R.C. (2003) WinSAAM: a windows-based compartmental modeling system. [Review] [18 refs]. Metabolism: Clinical & Experimental, 52, 1153-1166.
    • (2003) Metabolism: Clinical & Experimental , vol.52 , pp. 1153-1166
    • Stefanovski, D.1    Moate, P.J.2    Boston, R.C.3
  • 39
    • 12344321505 scopus 로고    scopus 로고
    • The effects of racemic ketamine on painful stimulation of skin and viscera in human subjects
    • Strigo, I.A., Duncan, G.H., Bushnell, C., Boivin, M., Wainer, I., Rosas, E.R. & Persson, J. (2005) The effects of racemic ketamine on painful stimulation of skin and viscera in human subjects. Pain, 113, 255-264.
    • (2005) Pain , vol.113 , pp. 255-264
    • Strigo, I.A.1    Duncan, G.H.2    Bushnell, C.3    Boivin, M.4    Wainer, I.5    Rosas, E.R.6    Persson, J.7
  • 40
    • 0035065337 scopus 로고    scopus 로고
    • Comparison of the effects of MK-801, ketamine and memantine on responses of spinal dorsal horn neurones in a rat model of mononeuropathy
    • Suzuki, R., Matthews, E.A. & Dickenson, A.H. (2001) Comparison of the effects of MK-801, ketamine and memantine on responses of spinal dorsal horn neurones in a rat model of mononeuropathy. Pain, 91, 101-109.
    • (2001) Pain , vol.91 , pp. 101-109
    • Suzuki, R.1    Matthews, E.A.2    Dickenson, A.H.3
  • 41
    • 0034796597 scopus 로고    scopus 로고
    • Ketamine inhibits endotoxin-induced shock in rats
    • Taniguchi, T., Shibata, K. & Yamamoto, K. (2001) Ketamine inhibits endotoxin-induced shock in rats. Anesthesiology, 95, 928-932.
    • (2001) Anesthesiology , vol.95 , pp. 928-932
    • Taniguchi, T.1    Shibata, K.2    Yamamoto, K.3
  • 42
    • 0344851897 scopus 로고    scopus 로고
    • The dose-related effects of ketamine on mortality and cytokine responses to endotoxin-induced shock in rats
    • Taniguchi, T., Takemoto, Y., Kanakura, H. & Yamamoto, K. (2003) The dose-related effects of ketamine on mortality and cytokine responses to endotoxin-induced shock in rats. Anesthesia Analgesia, 97, 1769-1772.
    • (2003) Anesthesia Analgesia , vol.97 , pp. 1769-1772
    • Taniguchi, T.1    Takemoto, Y.2    Kanakura, H.3    Yamamoto, K.4
  • 43
    • 1642502510 scopus 로고    scopus 로고
    • The antiinflammatory effects of ketamine in endotoxemic rats during moderate and mild hypothermia
    • Taniguchi, T., Kanakura, H., Takemoto, Y. & Yamamoto, K. (2004) The antiinflammatory effects of ketamine in endotoxemic rats during moderate and mild hypothermia. Anesthesia Analgesia, 98, 1114-1120.
    • (2004) Anesthesia Analgesia , vol.98 , pp. 1114-1120
    • Taniguchi, T.1    Kanakura, H.2    Takemoto, Y.3    Yamamoto, K.4
  • 45
    • 0016173684 scopus 로고
    • A safe method for rapidly achieving plasma cconcentration plateaus
    • Wagner, J.G. (1974) A safe method for rapidly achieving plasma cconcentration plateaus. Clinical Pharmacology and Therapeutics, 16, 691-700.
    • (1974) Clinical Pharmacology and Therapeutics , vol.16 , pp. 691-700
    • Wagner, J.G.1
  • 46
    • 0034625646 scopus 로고    scopus 로고
    • Repeated administration of low dose ketamine for the treatment of monoarthritic pain in the rat
    • Wang, Y., Huang, C., Cao, Y. & Han, J.S. (2000) Repeated administration of low dose ketamine for the treatment of monoarthritic pain in the rat. Life Sciences, 67, 261-267.
    • (2000) Life Sciences , vol.67 , pp. 261-267
    • Wang, Y.1    Huang, C.2    Cao, Y.3    Han, J.S.4
  • 49
    • 0023107228 scopus 로고
    • The pharmacokinetics of intravenously administered ketamine in the horse
    • Waterman, A.E., Robertson, S.A. & Lane, J.G. (1987) The pharmacokinetics of intravenously administered ketamine in the horse. Research in Veterinary Science, 42, 161-166.
    • (1987) Research in Veterinary Science , vol.42 , pp. 161-166
    • Waterman, A.E.1    Robertson, S.A.2    Lane, J.G.3
  • 50
    • 0020037594 scopus 로고
    • Ketamine its pharmacology and therapeutic uses
    • White, P.F., Way, W.L. & Trevor, A.J. (1982) Ketamine its pharmacology and therapeutic uses. Anesthesiology, 56, 119-136.
    • (1982) Anesthesiology , vol.56 , pp. 119-136
    • White, P.F.1    Way, W.L.2    Trevor, A.J.3
  • 51
    • 0025974775 scopus 로고
    • The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states
    • Woolf, C.J. & Thompson, S.W. (1991) The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states. Pain, 44, 293-299.
    • (1991) Pain , vol.44 , pp. 293-299
    • Woolf, C.J.1    Thompson, S.W.2
  • 53
    • 0032733588 scopus 로고    scopus 로고
    • Ketamine does not inhibit inflammatory responses of cultured human endothelial cells but reduces chemotactic activation of neutrophils
    • Zahler, S., Heindl, B. & Becker, B.F. (1999) Ketamine does not inhibit inflammatory responses of cultured human endothelial cells but reduces chemotactic activation of neutrophils. Acta Anaesthesiologica Scandinavica, 43, 1011-1016.
    • (1999) Acta Anaesthesiologica Scandinavica , vol.43 , pp. 1011-1016
    • Zahler, S.1    Heindl, B.2    Becker, B.F.3


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