Human cationic trypsinogen is sulfated on Tyr154

FEBS Journal

Volumn 273, Issue 22, 2006, Pages 5044-5050

  Sahin Tóth, Miklós ^a,b   Kukor, Zoltán ^a   Nemoda, Zsófia ^a  

^a BOSTON UNIVERSITY   (United States)

^b Evans 433 ^*  (United States)

Author keywords

Hereditary pancreatitis; Human anionic trypsin; Human cationic trypsin; Post translational modification; Tyrosine sulfation

Indexed keywords

ENZYME PRECURSOR; PHOSPHOTYROSINE; SODIUM SULFATE; TRYPSINOGEN; TYROSINE SULFATE;

ARTICLE; CATION EXCHANGE; CHEMICAL MODIFICATION; CONTROLLED STUDY; ELECTROPHORESIS; ENZYME ACTIVATION; ENZYME PURIFICATION; HUMAN; HUMAN CELL; HYDROLYSIS; MUTATIONAL ANALYSIS; NONHUMAN; PANCREAS JUICE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SULFATION; THIN LAYER CHROMATOGRAPHY;

ANIMALS; CATIONS; CATTLE; CELL LINE; CHROMATOGRAPHY, THIN LAYER; ELECTROPHORESIS; ENZYME ACTIVATION; HUMANS; HYDROLYSIS; PANCREATIC JUICE; PROTEIN PROCESSING, POST-TRANSLATIONAL; SULFUR; SULFUR COMPOUNDS; SULFUR ISOTOPES; TRYPSINOGEN; TYROSINE;

BOS TAURUS; PRIMATES; VERTEBRATA;

EID: 33750539321     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2006.05501.x     Document Type: Article

References (20)

1. Teich N, Rosendahl J, Tóth M, Mössner J & Sahin-Tóth M (2006) Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitis. Hum Mutat 27, 721-730.
2. Witt H, Sahin-Tóth M, Landt O, Chen JM, Kahne T, Drenth JP, Kukor Z, Szepessy E, Halangk W, Dahm S, et al. (2006) A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. Nat Genet 38, 668-673.
3. Gaboriaud C, Serre L, Guy-Crotte O, Forest E & Fontecilla-Camps JC (1996) Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151. J Mol Biol 259, 995-1010.
4. Szilágyi L, Kénesi E, Katona G, Kaslik G, Juhász G & Gráf L (2001) Comparative in vitro studies on native and recombinant human cationic trypsins. Cathepsin B is a possible pathological activator of trypsinogen in pancreatitis. J Biol Chem 276, 24574-24580.
5. Scheele G, Bartelt D & Bieger W (1981) Characterization of human exocrine pancreatic proteins by two-dimensional isoelectric focusing/sodium dodecyl sulfate gel electrophoresis. Gastroenterology 80, 461-473.
6. Bettelheim FR (1954) Tyrosine-O-sulfate in a peptide from fibrinogen. J Am Chem Soc 76, 2838-2839.
7. Huttner WB (1982) Sulphation of tyrosine residues - a widespread modification of proteins. Nature 299, 273-276.
8. Huttner WB (1984) Determination and occurrence of tyrosine O-sulfate in proteins. Methods Enzymol 107, 200-223.
9. Blode H, Heinrich T & Diringer H (1990) A quantitative assay for tyrosine sulfation and tyrosine phosphorylation in peptides. Biol Chem Hoppe Seyler 371, 145-151.
10. Moore KL (2003) The biology and enzymology of protein tyrosine O-sulfation. J Biol Chem 278, 24243-24246.
11. Ouyang Y, Lane WS & Moore KL (1998) Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins. Proc Natl Acad Sci USA 95, 2896-2901.
12. Beisswanger R, Corbeil D, Vannier C, Thiele C, Dohrmann U, Kellner R, Ashman K, Niehrs C & Huttner WB (1998) Existence of distinct tyrosylprotein sulfotransferase genes: molecular characterization of tyrosylprotein sulfotransferase-2. Proc Natl Acad Sci USA 95, 11134-11139.
13. Ouyang YB & Moore KL (1998) Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans. J Biol Chem 273, 24770-24774.
14. Ouyang YB, Crawley JT, Aston CE & Moore KL (2002) Reduced body weight and increased postimplantation fetal death in tyrosylprotein sulfotransferase-1-deficient mice. J Biol Chem 277, 23781-23787.
15. Borghei A, Ouyang YB, Westmuckett AD, Marcello MR, Landel CP, Evans JP & Moore KL (2006) Targeted disruption of tyrosylprotein sulfotransferase-2, an enzyme that catalyzes post-translational protein tyrosine O-sulfation, causes male infertility. J Biol Chem 281, 9423-9431.
16. Keim V, Iovanna JL, Orelle B, Verdier JM, Busing M, Hopt U & Dagorn JC (1992) A novel exocrine protein associated with pancreas transplantation in humans. Gastroenterology 103, 248-254.
17. Nemoda Z & Sahin-Tóth M (2006) Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen. J Biol Chem 281, 11879-11886.
18. Sahin-Tóth M (2000) Human cationic trypsinogen. Role of Asn-21 in zymogen activation and implications in hereditary pancreatitis. J Biol Chem 275, 22750-22755.
19. Sahin-Tóth M & Tóth M (2000) Gain-of-function mutations associated with hereditary pancreatitis enhance autoactivation of human cationic trypsinogen. Biochem Biophys Res Commun 278, 286-289.
20. Kukor Z, Tóth M & Sahin-Tóth M (2003) Human anionic trypsinogen. Properties of autocatalytic activation and degradation and implications in pancreatic diseases. Eur J Biochem 270, 2047-2058.