Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice

Genes, Brain and Behavior

Volumn 5, Issue 8, 2006, Pages 614-623

  Martin, Maureen V ^a,b   Dong, Hongxin ^a   Vallera, Dana ^a   Lee, David ^a   Lu, Lu ^c   Williams, Robert W ^c   Rosen, Glenn D ^d   Cheverud, James M ^a   Csernansky, John G ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAINT LOUIS UNIVERSITY   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Anterior hippocampus; AXB BXA; BXD; Dorsal hippocampus; Mice; Posterior hippocampus; Quantitative trait locus; Recombinant inbred strains; Schizophrenia; Ventral hippocampus

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; CHROMOSOME 13; CHROMOSOME 15; CHROMOSOME 2; CHROMOSOME 5; CHROMOSOME 8; CHROMOSOME ANALYSIS; GENE LOCUS; GENETIC CORRELATION; HIPPOCAMPUS; INBREEDING; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS;

AGE FACTORS; ANIMALS; CHROMOSOME MAPPING; FEMALE; HIPPOCAMPUS; MALE; MICE; MICE, INBRED STRAINS; ORGAN SIZE; PHENOTYPE; QUANTITATIVE TRAIT LOCI; RECOMBINATION, GENETIC; SEX FACTORS; SPECIES SPECIFICITY;

EID: 33750533789     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2006.00215.x     Document Type: Article

References (34)

1. Arnold, S.E. & Trojanowski, J.Q. (1996) Human fetal hippocampi development: I. Cytoarchitecture, myeloarchitecture, and neuronal morphologic features. J Comp Neurol 267, 274-292.
2. Bannerman, D.M., Grubb, M., Deacon, R.M.J., Yee, B.K. & Feldon, J. (2003) Ventral hippocampal lesions affect anxiety but not spatial learning. Behav Brain Res 139, 197-213.
3. Bannerman, D.M., Rawlins, J.N., McHugh, S.B., Deacon, R.M., Yee, B.K., Bast, T., Zhang, W.N., Pothuizen, H.H. & Feldon, J. (2004) Regional dissociations within the hippocampus - memory and anxiety. Neurosci Biobehav Rev 28, 273-283.
4. Benes, F.M., Turtle, M., Khan, Y. & Farol, P. (1994) Myelination of a key relay zone in the hippocampal formation occurs in the human brain during childhood, adolescence, adulthood. Arch Gen Psychiatry 51, 477-484.
5. Bernasconi, N., Bernasconi, A., Caramanos, Z., Antel, S.B., Andermann, F. & Arnold, D.L. (2003) Mesial temporal damage in temporal lobe epilepsy: a volume tric MRI study of the hippocampus, amygdale and parahippocampal region. Brain 126, 462-469.
6. Cheverud, J.M., Ehrich, T.H., Hrbek, T., Kenney, J.P., Pletscher, L.S. & Semenkovich, C.F. (2004) Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains. Diabetes 53, 3328-3336.
7. Csernansky, J.G., Wang, L., Jones, D., Rastogi-Cruz, D., Posener, J.A., Heydebrand, G., Miller, J.P. & Miller, M.I. (2002) Hippocampal deformities in schizophrenia characterized by high dimensional brain mapping. Am J Psychiatry 159, 2000-2006.
8. Deacon, R.M.J. & Rawlins, J.N.P. (2005) Hippocampal lesions, species-typical behaviors and anxiety in mice. Behav Brain Res 156, 241-249.
9. Degroot, A. & Treit, D. (2004) Anxiety is functionally segregated within the septo-hippocampal system. Brain Res 19, 60-71.
10. Falconer, D.S. & Mackay, T. (1997) Introduction to Quantitative Genetics. John Wiley & Sons, New York.
11. Friedman, D.P., Aggleton, J.P. & Saunders, R. (2002) Comparison of hippocampal, amygdala, and perirhinal projections to the nucleus accumbens: combined anterograde and retrograde tracing study in the macaque brain. J Comp Neurol 450, 345-365.
12. Goldman, M.B. & Mitchell, C.P. (2004) What is the functional significance of hippocampal pathology in schizophrenia? Schizophr Bull 30, 367-392.
13. van Groen, T., Miettinen, P. & Kadish, I. (2003) The entorhinal cortex of the mouse: organization of the projection to the hippocampal formation. Hippocampus 13, 133-149.
14. Hörtnagl, H., Berger, M.L., Sperk, G. & Pifl, C.H. (1991) Regional heterogeneity in the distribution of neurotransmitter markers in the rat hippocampus. Neuroscience 45, 261-272.
15. Kusljic, S. & van den Buuse, M. (2004) Functional dissociation between serotonergic pathways in dorsal and ventral hippocampus in psychotomimetic drug-induced locomotor hyperactivity and prepulse inhibition. Eur J Neurosci 20, 3424-3432.
16. Maguire, E.A., Spiers, H.J., Good, C.D., Hartley, T., Frackowiak, R.S. & Burgess, N. (2003) Navigation expertise and the human hippocampus: a structural brain imaging analysis. Hippocampus 13, 250-259.
17. Moser, M.-B. & Moser, E.I. (1998) Functional differentiation in the hippocampus. Hippocampus 8, 608-619.
18. Nelson, M.D., Saykin, A.J., Flashman, L.A. & Riordan, H.J. (1998) Hippocampal Volume reduction in schizophrenia as assessed by magnetic resonance imaging: a meta-analytic study. Arch Gen Psychiatry 55, 433-440.
19. Neumeister, A., Wood, S., Bonne, O., Nugent, A.C., Luckenbaugh, D.A., Young, T., Bain, E.E., Charney, D.S. & Drevets, W.C. (2005) Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects. Biol Psychiatry 57, 935-937.
20. Peirce, J.L., Chesler, E.J., Williams, R.W. & Lu, L. (2003) Genetic architecture of the mouse hippocampus: identification of gene loci with selective regional effects. Genes Brain Behav 2, 238-252.
21. van Petten, C. (2004) Relationship between hippocampal Volume and memory ability in healthy individuals across the lifespan: review and meta-analysis. Neuropsychologia 42, 1394-1413.
22. Pitkänen, A., Pikkarainen, M., Nurminen, N. & Ylinen, A. (2000) Recipricol connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat. Ann N Y Acad Sci 911, 369-391.
23. Pothuizen, H.H.J., Zhang, W.N., Jongen-Rêlo, A.L., Feldon, J. & Yee, B.K. (2004) Dissociation of function between the dorsal and ventral hippocampus in spatial learning abilities of the rat: a within-subject, within-task comparison of reference and working spatial memory. Eur J Neurosci 19, 705-712.
24. Richmond, M.A., Pouzet, B., Veeman, L., Feldon, J., Yee, B.K., Rawlins, J.N.P. & Bannerman, D.M. (1999) Dissociating context and space within the hippocampus: effects of complete, dorsal, and ventral excitotoxic hippocampal lesions on conditioned freezing and spatial learning. Behav Neurosci 113, 1189-1203.
25. Sokal, R.R. & Rohlf, F.J. (1994) Biometry, 3rd ed. Freeman, San Francisco, CA, USA.
26. Sullivan, E.V., Marsh, L. & Pfefferbaum, A. (2005) Preservation of hippocampal volume throughout adulthood in healthy men and women. Neurobiol Aging 26, 1093-1098.
27. Szentkuti, A., Guderian, S., Schiltz, K., Kaufmann, J., Munte, T.F., Heinze, H.J. & Duzel, E. (2004) Quantitative MR analyses of the hippocampus: unspecific metabolic changes in aging. J Neurol 251, 1345-1353.
28. Tepest, R., Wang, L., Miller, M.I., Falkai, P. & Csernansky, J.G. (2003) Hippocampal deformities in the unaffected siblings of schizophrenia subjects. Biol Psychiatry 11, 1234-1240.
29. Trivedi, M.A. & Coover, G.D. (2004) Lesions of the ventral hippocampus, but not the dorsal hippocampus, impair conditioned fear expression and inhibitory avoidance on the elevated T-maze. Neurobiol Learn Mem 81, 172-184.
30. Utsunomiya, H., Takani, K., Okazaki, M. & Mitsudome, A. (1999) Development of the temporal lobe in infants and children: analysis by MR-based volume try. AJNR Am J Neuroradiol 20, 717-723.
31. Verwer, R.W., Meijer, R.J., Van Uum, H.F. & Witter, M.P. (1997) Collateral projections from the rat hippocampal formation to the lateral and medial prefrontal cortex. Hippocampus 7, 397-402.
32. Williams, R.W., Gu, J., Qi, S. & Lu, L. (2001) The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis. Genome Biol 11, research0046.
33. Witter, M.P., Van Hoesen, G.W. & Amaral, D.G. (1989) Topographical organization of the entorhinal projection to the dentate gyrus of the monkey. J Neurosci 9, 216-228.
34. Zygourakis, C.C. & Rosen, G.D. (2003) Quantitative trait loci modulate ventricular size in the mouse brain. J Comp Neuro 461, 362-369.