-
1
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987; 235: 177-82.
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
Levin, W.J.4
Ullrich, A.5
McGuire, W.L.6
-
2
-
-
0024337144
-
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
-
Slamon DJ, Godolphin W, Jones LA, et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989; 244: 707-12.
-
(1989)
Science
, vol.244
, pp. 707-712
-
-
Slamon, D.J.1
Godolphin, W.2
Jones, L.A.3
-
3
-
-
21644438384
-
The diverse signaling network of EGFR, HER2, HER3 and HER4 tyrosine kinase receptors and the consequences for therapeutic approaches
-
Zaczek A, Brandt B, Bielawski KP. The diverse signaling network of EGFR, HER2, HER3 and HER4 tyrosine kinase receptors and the consequences for therapeutic approaches. Histol Histopathol 2005; 20: 1005-15.
-
(2005)
Histol Histopathol
, vol.20
, pp. 1005-1015
-
-
Zaczek, A.1
Brandt, B.2
Bielawski, K.P.3
-
4
-
-
0028941212
-
Identification and characterization of c-erbB-2 proteins in serum, breast tumor tissue, and SK-BR-3 cell line
-
Wu JT, Zhang P, Astill ME, Lyons BW, Wu LH. Identification and characterization of c-erbB-2 proteins in serum, breast tumor tissue, and SK-BR-3 cell line. J Clin Lab Anal 1995; 9: 141-50.
-
(1995)
J Clin Lab Anal
, vol.9
, pp. 141-150
-
-
Wu, J.T.1
Zhang, P.2
Astill, M.E.3
Lyons, B.W.4
Wu, L.H.5
-
5
-
-
0033559210
-
Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells
-
Codony-Servat J, Albanell J, Lopez-Talavera JC, Arribas J, Baselga J. Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells. Cancer Res 1999; 59: 1196-201.
-
(1999)
Cancer Res
, vol.59
, pp. 1196-1201
-
-
Codony-Servat, J.1
Albanell, J.2
Lopez-Talavera, J.C.3
Arribas, J.4
Baselga, J.5
-
6
-
-
0035874981
-
Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells
-
Molina MA, Codony-Servat J, Albanell J, Rojo F, Arribas J, Baselga J. Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells. Cancer Res 2001; 61: 4744-9.
-
(2001)
Cancer Res
, vol.61
, pp. 4744-4749
-
-
Molina, M.A.1
Codony-Servat, J.2
Albanell, J.3
Rojo, F.4
Arribas, J.5
Baselga, J.6
-
7
-
-
0028358856
-
Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin
-
Sliwkowski MX, Schaefer G, Akita RW, et al. Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin. J Biol Chem 1994; 269: 14661-5.
-
(1994)
J Biol Chem
, vol.269
, pp. 14661-14665
-
-
Sliwkowski, M.X.1
Schaefer, G.2
Akita, R.W.3
-
8
-
-
2442701289
-
The ErbB/HER receptor protein-tyrosine kinases and cancer
-
Roskoski R Jr. The ErbB/HER receptor protein-tyrosine kinases and cancer. Biochem Biophys Res Commun 2004; 319: 1-11.
-
(2004)
Biochem Biophys Res Commun
, vol.319
, pp. 1-11
-
-
Roskoski Jr., R.1
-
9
-
-
0024023873
-
Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3
-
King CR, Borrello I, Bellot F, Comoglio P, Schlessinger J. Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3. Embo J 1988; 7: 1647-51.
-
(1988)
Embo J
, vol.7
, pp. 1647-16351
-
-
King, C.R.1
Borrello, I.2
Bellot, F.3
Comoglio, P.4
Schlessinger, J.5
-
10
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001; 344: 783-92.
-
(2001)
N Engl J Med
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
11
-
-
22344446208
-
Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group
-
Marty M, Cognetti F, Maraninchi D, et al. Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group. J Clin Oncol 2005; 23: 4265-74.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4265-4274
-
-
Marty, M.1
Cognetti, F.2
Maraninchi, D.3
-
12
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
-
Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005; 353: 1673-84.
-
(2005)
N Engl J Med
, vol.353
, pp. 1673-1684
-
-
Romond, E.H.1
Perez, E.A.2
Bryant, J.3
-
13
-
-
26844503270
-
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
-
Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005; 353: 1659-72.
-
(2005)
N Engl J Med
, vol.353
, pp. 1659-1672
-
-
Piccart-Gebhart, M.J.1
Procter, M.2
Leyland-Jones, B.3
-
14
-
-
0141615794
-
Potential clinical utility of serum HER-2/neu oncoprotein concentrations in patients with breast cancer
-
Carney WP, Neumann R, Lipton A, Leitzel K, Ali S, Price CP. Potential clinical utility of serum HER-2/neu oncoprotein concentrations in patients with breast cancer. Clin Chem 2003; 49: 1579-98.
-
(2003)
Clin Chem
, vol.49
, pp. 1579-1598
-
-
Carney, W.P.1
Neumann, R.2
Lipton, A.3
Leitzel, K.4
Ali, S.5
Price, C.P.6
-
15
-
-
0036534121
-
Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer
-
Esteva FJ, Valero V, Booser D, et al. Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer. J Clin Oncol 2002; 20: 1800-8.
-
(2002)
J Clin Oncol
, vol.20
, pp. 1800-1808
-
-
Esteva, F.J.1
Valero, V.2
Booser, D.3
-
16
-
-
33644528230
-
Clinical utility of serum HER2/neu in monitoring and prediction of progression-free survival in metastatic breast cancer patients treated with trastuzumab-based therapies
-
Esteva FJ, Cheli CD, Fritsche H, et al. Clinical utility of serum HER2/ neu in monitoring and prediction of progression-free survival in metastatic breast cancer patients treated with trastuzumab-based therapies. Breast Cancer Res 2005; 7: R436-R43.
-
(2005)
Breast Cancer Res
, vol.7
-
-
Esteva, F.J.1
Cheli, C.D.2
Fritsche, H.3
-
17
-
-
3543146052
-
Monitoring of serum Her-2/neu predicts response and progression-free survival to trastuzumab-based treatment in patients with metastatic breast cancer
-
Köstler WJ, Schwab B, Singer CF, et al. Monitoring of serum Her-2/ neu predicts response and progression-free survival to trastuzumab-based treatment in patients with metastatic breast cancer. Clin Cancer Res 2004; 10: 1618-24.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 1618-1624
-
-
Köstler, W.J.1
Schwab, B.2
Singer, C.F.3
-
18
-
-
6444240419
-
ADVIA Centaur HER-2/neu shows value in monitoring patients with metastatic breast
-
Lüftner D, Cheli C, Mickelson K, Sampson E, Possinger K. ADVIA Centaur HER-2/neu shows value in monitoring patients with metastatic breast cancer. Int J Biol Markers 2004; 19: 175-82.
-
(2004)
Cancer Int J Biol Markers
, vol.19
, pp. 175-182
-
-
Lüftner, D.1
Cheli, C.2
Mickelson, K.3
Sampson, E.4
Possinger, K.5
-
19
-
-
0037388251
-
ZD1839, a specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces the formation of inactive EGFR/HER2 and EGFR/ HER3 heterodimers and prevents heregulin signaling in HER2-overexpressing breast cancer cells
-
Anido J, Matar P, Albanell J, et al. ZD1839, a specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces the formation of inactive EGFR/HER2 and EGFR/HER3 heterodimers and prevents heregulin signaling in HER2-overexpressing breast cancer cells. Clin Cancer Res 2003; 9: 1274-83.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1274-1283
-
-
Anido, J.1
Matar, P.2
Albanell, J.3
-
20
-
-
0034722889
-
The EGF receptor family as targets for cancer therapy
-
Mendelsohn J, Baselga J. The EGF receptor family as targets for cancer therapy. Oncogene 2001; 19: 6550-65.
-
(2001)
Oncogene
, vol.19
, pp. 6550-6565
-
-
Mendelsohn, J.1
Baselga, J.2
-
21
-
-
0037931402
-
Quantitative analysis of HER2-mediated effects on HER2 and epidermal growth factor receptor endocytosis: Distribution of homo- and heterodimers depends on relative HER2
-
Hendriks BS, Opresko LK, Wiley HS, Lauffenburger D. Quantitative analysis of HER2-mediated effects on HER2 and epidermal growth factor receptor endocytosis: distribution of homo- and heterodimers depends on relative HER2 levels. J Biol Chem 2003; 278: 23343-51.
-
(2003)
Levels J Biol Chem
, vol.278
, pp. 23343-23351
-
-
Hendriks, B.S.1
Opresko, L.K.2
Wiley, H.S.3
Lauffenburger, D.4
-
22
-
-
0037106273
-
Targeting the epidermal growth factor receptor for cancer therapy
-
Mendelsohn J. Targeting the epidermal growth factor receptor for cancer therapy. J Clin Oncol 2002; 20: 1S-13S.
-
(2002)
J Clin Oncol
, vol.20
-
-
Mendelsohn, J.1
-
23
-
-
4644301280
-
Normal levels of serum EGFR and decreases in several cancers
-
Carney W, Burrell M, Morris LD, Hamer P. Normal levels of serum EGFR and decreases in several cancers. Proc AACR 2002; 43: 240.
-
(2002)
Proc AACR
, vol.43
, pp. 240
-
-
Carney, W.1
Burrell, M.2
Morris, L.D.3
Hamer, P.4
-
24
-
-
12244261580
-
Soluble epidermal growth factor receptor (sEGFR/sErbB1) as a potential risk, screening, and diagnostic serum biomarker of epithelial ovarian cancer
-
Baron AT, Cora EM, Lafky JM, et al. Soluble epidermal growth factor receptor (sEGFR/sErbB1) as a potential risk, screening, and diagnostic serum biomarker of epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev 2003; 12: 103-13.
-
(2003)
Cancer Epidemiol Biomarkers Prev
, vol.12
, pp. 103-113
-
-
Baron, A.T.1
Cora, E.M.2
Lafky, J.M.3
-
25
-
-
0035884620
-
Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: Evidence from a phase III randomized trial
-
Ellis MJ, Coop A, Singh B, et al. Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a phase III randomized trial. J Clin Oncol 2001; 19: 3808-16.
-
(2001)
J Clin Oncol
, vol.19
, pp. 3808-3816
-
-
Ellis, M.J.1
Coop, A.2
Singh, B.3
-
26
-
-
0034666345
-
Activation (tyrosine phosphorylation) of ErbB-2 (HER-2/neu): A study of incidence and correlation with outcome in breast cancer
-
Thor AD, Liu S, Edgerton S, et al. Activation (tyrosine phosphorylation) of ErbB-2 (HER-2/neu): a study of incidence and correlation with outcome in breast cancer. J Clin Oncol 2000; 18: 3230-9.
-
(2000)
J Clin Oncol
, vol.18
, pp. 3230-3239
-
-
Thor, A.D.1
Liu, S.2
Edgerton, S.3
-
27
-
-
0037087535
-
Elevated serum her-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer
-
Lipton A, Ali SM, Leitzel K, et al. Elevated serum her-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer. J Clin Oncol 2002; 20: 1467-72.
-
(2002)
J Clin Oncol
, vol.20
, pp. 1467-1472
-
-
Lipton, A.1
Ali, S.M.2
Leitzel, K.3
-
28
-
-
33645823082
-
Serum EGFR/HER-2 combination predicts poor survival in metastatic breast cancer
-
(abstract)
-
Leitzel K, Souder C, Ali S, et al. Serum EGFR/HER-2 combination predicts poor survival in metastatic breast cancer. Proc ASCO 2005; 9613 (abstract).
-
(2005)
Proc ASCO
, pp. 9613
-
-
Leitzel, K.1
Souder, C.2
Ali, S.3
-
29
-
-
3142769775
-
Prognostic and predictive impact of the HER-2/neu extracellular domain (ECD) in the serum of patients treated with chemotherapy for metastatic breast cancer
-
Müller V, Witzel I, Lück H, et al. Prognostic and predictive impact of the HER-2/neu extracellular domain (ECD) in the serum of patients treated with chemotherapy for metastatic breast cancer. Breast Cancer Res Treat 2004; 86: 9-18.
-
(2004)
Breast Cancer Res Treat
, vol.86
, pp. 9-18
-
-
Müller, V.1
Witzel, I.2
Lück, H.3
-
30
-
-
0034518668
-
Monitoring therapy by serum HER-2/neu
-
Schwartz MK, Smith C, Schwartz DC, Dnistrian A, Neiman I. Monitoring therapy by serum HER-2/neu. Int J Biol Markers 2000; 15: 324-9.
-
(2000)
Int J Biol Markers
, vol.15
, pp. 324-329
-
-
Schwartz, M.K.1
Smith, C.2
Schwartz, D.C.3
Dnistrian, A.4
Neiman, I.5
-
31
-
-
0029005754
-
Elevated serum c-erbB-2 antigen levels and decreased response to hormone therapy of breast cancer
-
Leitzel K, Teramoto Y, Konrad K, et al. Elevated serum c-erbB-2 antigen levels and decreased response to hormone therapy of breast cancer. J Clin Oncol 1995; 13: 1129-35.
-
(1995)
J Clin Oncol
, vol.13
, pp. 1129-1135
-
-
Leitzel, K.1
Teramoto, Y.2
Konrad, K.3
-
32
-
-
0035447953
-
Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer stage IV colon adenocarcinoma: Implications for a standardized scoring system
-
Goldstein NS, Armin M. Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer stage IV colon adenocarcinoma: implications for a standardized scoring system. Cancer 2001; 92: 1331-46.
-
(2001)
Cancer
, vol.92
, pp. 1331-1346
-
-
Goldstein, N.S.1
Armin, M.2
-
33
-
-
0037010058
-
Epidermal growth factor receptor expression and measurement in solid tumors
-
Spaulding DC, Spaulding BO. Epidermal growth factor receptor expression and measurement in solid tumors. Semin Oncol 2002; 29: 45-54.
-
(2002)
Semin Oncol
, vol.29
, pp. 45-54
-
-
Spaulding, D.C.1
Spaulding, B.O.2
-
34
-
-
14544277088
-
Relationship of epidermal growth factor receptor expression to ErbB-2 signaling activity and prognosis in breast cancer patients
-
DiGiovanna MP, Stern DF, Edgerton SM, Whalen SG, Moore D, 2nd, Thor AD. Relationship of epidermal growth factor receptor expression to ErbB-2 signaling activity and prognosis in breast cancer patients. J Clin Oncol 2005; 23: 1152-60.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1152-1160
-
-
DiGiovanna, M.P.1
Stern, D.F.2
Edgerton, S.M.3
Whalen, S.G.4
Moore II, D.5
Thor, A.D.6
-
35
-
-
23444460828
-
Epidermal growth factor receptor expression correlates with poor survival in patients who have breast carcinoma treated with doxorubicin-based neoadjuvant chemotherapy
-
Buchholz TA, Tu X, Ang KK, et al. Epidermal growth factor receptor expression correlates with poor survival in patients who have breast carcinoma treated with doxorubicin-based neoadjuvant chemotherapy. Cancer 2005; 104: 676-81.
-
(2005)
Cancer
, vol.104
, pp. 676-681
-
-
Buchholz, T.A.1
Tu, X.2
Ang, K.K.3
-
36
-
-
0024822342
-
Epidermal growth factor receptors in breast cancer: Association with early relapse and death, poor response to hormones and interactions with neu
-
Harris AL, Nicholson S, Sainsbury JR, Farndon J, Wright C. Epidermal growth factor receptors in breast cancer: association with early relapse and death, poor response to hormones and interactions with neu. J Steroid Biochem 1989; 34: 123-31.
-
(1989)
J Steroid Biochem
, vol.34
, pp. 123-131
-
-
Harris, A.L.1
Nicholson, S.2
Sainsbury, J.R.3
Farndon, J.4
Wright, C.5
-
37
-
-
0036164390
-
Prognostic value of epidermal growth factor receptor (EGFR) and its relationship to the estrogen receptor status in 1029 patients with breast cancer
-
Tsutsui S, Ohno S, Murakami S, Hachitanda Y, Oda S. Prognostic value of epidermal growth factor receptor (EGFR) and its relationship to the estrogen receptor status in 1029 patients with breast cancer. Breast Cancer Res Treat 2002; 71: 67-75.
-
(2002)
Breast Cancer Res Treat
, vol.71
, pp. 67-75
-
-
Tsutsui, S.1
Ohno, S.2
Murakami, S.3
Hachitanda, Y.4
Oda, S.5
-
38
-
-
0028293921
-
Epidermal growth factor receptor expression in breast cancer: Association with response to endocrine therapy
-
Nicholson RI, McClelland RA, Gee JM, et al. Epidermal growth factor receptor expression in breast cancer: association with response to endocrine therapy. Breast Cancer Res Treat 1994; 29: 117-25.
-
(1994)
Breast Cancer Res Treat
, vol.29
, pp. 117-125
-
-
Nicholson, R.I.1
McClelland, R.A.2
Gee, J.M.3
-
39
-
-
20244388653
-
Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies
-
Spector NL, Xia W, Burris H, 3rd, et al. Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies. J Clin Oncol 2005; 23: 2502-12.
-
(2005)
J Clin Oncol
, vol.23
, pp. 2502-2512
-
-
Spector, N.L.1
Xia, W.2
Burris III, H.3
-
40
-
-
0035161223
-
A preliminary study of serum concentrations of soluble epidermal growth factor receptor (sErbB1), gonadotropins, and steroid hormones in healthy men and women
-
Baron AT, Lafky JM, Suman VJ, et al. A preliminary study of serum concentrations of soluble epidermal growth factor receptor (sErbB1), gonadotropins, and steroid hormones in healthy men and women. Cancer Epidemiol Biomarkers Prev 2001; 10: 1175-85.
-
(2001)
Cancer Epidemiol Biomarkers Prev
, vol.10
, pp. 1175-1185
-
-
Baron, A.T.1
Lafky, J.M.2
Suman, V.J.3
|