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Volumn 16, Issue 23, 2006, Pages 6024-6027
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Enzyme inhibition potency enhancement by active site metal chelating and hydrogen bonding induced conformation-restricted cyclopropanecarbonyl derivatives
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Author keywords
Conformation restricted; Enzyme inhibition; Hydrogen bonding; Metal chelating
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Indexed keywords
CARBONYL DERIVATIVE;
CYCLOPROPANE DERIVATIVE;
CYCLOPROPANECARBONYL DERIVATIVE;
UNCLASSIFIED DRUG;
ARTICLE;
CHELATION;
CONFORMATIONAL TRANSITION;
CRYSTAL STRUCTURE;
DRUG CONFORMATION;
DRUG POTENCY;
DRUG RECEPTOR BINDING;
DRUG SYNTHESIS;
ENZYME ACTIVE SITE;
ENZYME INHIBITION;
HYDROGEN BOND;
LIGAND BINDING;
MOLECULAR INTERACTION;
X RAY CRYSTALLOGRAPHY;
4-HYDROXYPHENYLPYRUVATE DIOXYGENASE;
ANIMALS;
BINDING SITES;
CHELATING AGENTS;
CRYSTALLOGRAPHY, X-RAY;
CYCLOPROPANES;
ENZYME INHIBITORS;
FACTOR XA;
HYDROGEN BONDING;
METALS;
MODELS, MOLECULAR;
MOLECULAR CONFORMATION;
OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS;
RATS;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 33750512746
PISSN: 0960894X
EISSN: None
Source Type: Journal
DOI: 10.1016/j.bmcl.2006.08.125 Document Type: Article |
Times cited : (10)
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References (18)
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