-
1
-
-
0035939330
-
Studies leading to the identification of ZD1839 (IRESSA): An orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer
-
Barker AJ, Gibson KH, Grundy W, Godfrey AA, Barlow JJ, Healy MP, Woodburn JR, Ashton SE, Curry BJ, Scarlett L, Henthorn L, Richards L: Studies leading to the identification of ZD1839 (IRESSA): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer. Bioorg Med Chem Lett 11: 1911-1914, 2001
-
(2001)
Bioorg Med Chem Lett
, vol.11
, pp. 1911-1914
-
-
Barker, A.J.1
Gibson, K.H.2
Grundy, W.3
Godfrey, A.A.4
Barlow, J.J.5
Healy, M.P.6
Woodburn, J.R.7
Ashton, S.E.8
Curry, B.J.9
Scarlett, L.10
Henthorn, L.11
Richards, L.12
-
2
-
-
0038166890
-
Epidermal growth factor receptor targeted therapy by ZD 1839 (Iressa) in patients with brain metastases from non-small cell lung cancer (NSCLC)
-
Cappuzzo F, Ardizzoni A, Soto-Parra H, Gridelli C, Maione P, Tiseo M, Calandri C, Bartolini S, Santoro A, Crino L: Epidermal growth factor receptor targeted therapy by ZD 1839 (Iressa) in patients with brain metastases from non-small cell lung cancer (NSCLC). Lung Cancer 41: 227-231, 2003
-
(2003)
Lung Cancer
, vol.41
, pp. 227-231
-
-
Cappuzzo, F.1
Ardizzoni, A.2
Soto-Parra, H.3
Gridelli, C.4
Maione, P.5
Tiseo, M.6
Calandri, C.7
Bartolini, S.8
Santoro, A.9
Crino, L.10
-
3
-
-
0042121200
-
ZD 1839 in patients with brain metastases from non-small-cell lung cancer (NSCLC): Report of four cases
-
Cappuzzo F, Calandri C, Bartolini S, Crino L: ZD 1839 in patients with brain metastases from non-small-cell lung cancer (NSCLC): report of four cases. Br J Cancer 89: 246-247, 2003
-
(2003)
Br J Cancer
, vol.89
, pp. 246-247
-
-
Cappuzzo, F.1
Calandri, C.2
Bartolini, S.3
Crino, L.4
-
4
-
-
0034896362
-
Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor
-
Ciardiello F, Caputo R, Bianco R, Damiano V, Fontanini G, Cuccato S, De Placido S, Bianco AR, Tortora G: Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor. Clin Cancer Res 7: 1459-1465, 2001
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1459-1465
-
-
Ciardiello, F.1
Caputo, R.2
Bianco, R.3
Damiano, V.4
Fontanini, G.5
Cuccato, S.6
De Placido, S.7
Bianco, A.R.8
Tortora, G.9
-
5
-
-
0037674062
-
Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck
-
Cohen EEW, Rosen F, Stadler WM, Recant W, Stenson K, Huo D, Vokes EE: Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol 21: 1980-1987, 2003
-
(2003)
J Clin Oncol
, vol.21
, pp. 1980-1987
-
-
Cohen, E.E.W.1
Rosen, F.2
Stadler, W.M.3
Recant, W.4
Stenson, K.5
Huo, D.6
Vokes, E.E.7
-
6
-
-
0043210670
-
FDA drug approval summary: Gefitinib (ZD1839) (Iressa) tablets
-
Cohen MH, Williams GA, Sridhara R, Chen G, Pazdur R: FDA drug approval summary: gefitinib (ZD1839) (Iressa) tablets. Oncologist 8: 303-306, 2003
-
(2003)
Oncologist
, vol.8
, pp. 303-306
-
-
Cohen, M.H.1
Williams, G.A.2
Sridhara, R.3
Chen, G.4
Pazdur, R.5
-
7
-
-
2342429344
-
Report of Brain Tumor Registry of Japan (1969-1996)
-
Committee of Brain Tumor Registry of Japan: 1-111
-
Committee of Brain Tumor Registry of Japan: Report of Brain Tumor Registry of Japan (1969-1996). Neurol Med Chir (Tokyo) 43 Suppl: i-vii, 1-111, 2003
-
(2003)
Neurol Med Chir (Tokyo)
, vol.43
, Issue.SUPPL.
-
-
-
8
-
-
0345714775
-
Phase II trial of ZD1839 (IRESSA) in patients with advanced renal cell carcinoma
-
Drucker B, Bacik J, Ginsberg M, Marion S, Russo P, Mazumdar M, Motzer R: Phase II trial of ZD1839 (IRESSA) in patients with advanced renal cell carcinoma. Invest New Drugs 21: 341-345, 2003
-
(2003)
Invest New Drugs
, vol.21
, pp. 341-345
-
-
Drucker, B.1
Bacik, J.2
Ginsberg, M.3
Marion, S.4
Russo, P.5
Mazumdar, M.6
Motzer, R.7
-
9
-
-
0028937815
-
Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype
-
Fontanini G, Vignati S, Bigini D, Mussi A, Lucchi H, Angeletti CA, Pingitore R, Pepe S, Basolo F, Bevilacqua G: Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype. Eur J Cancer 31A: 178-183, 1995
-
(1995)
Eur J Cancer
, vol.31 A
, pp. 178-183
-
-
Fontanini, G.1
Vignati, S.2
Bigini, D.3
Mussi, A.4
Lucchi, H.5
Angeletti, C.A.6
Pingitore, R.7
Pepe, S.8
Basolo, F.9
Bevilacqua, G.10
-
10
-
-
0012381722
-
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial)
-
Fukuoka M, Yano S, Giaccone G, Tamura T, Nakagawa K, Douillard JY, Nishiwaki Y, Vansteenkiste J, Kudoh S, Rischin D, Eek R, Horai T, Noda K, Takata I, Smit E, Averbuch S, Macleod A, Feyereislova A, Dong RP, Baselga J: Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial). J Clin Oncol 21: 2237-2246, 2003
-
(2003)
J Clin Oncol
, vol.21
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
Tamura, T.4
Nakagawa, K.5
Douillard, J.Y.6
Nishiwaki, Y.7
Vansteenkiste, J.8
Kudoh, S.9
Rischin, D.10
Eek, R.11
Horai, T.12
Noda, K.13
Takata, I.14
Smit, E.15
Averbuch, S.16
Macleod, A.17
Feyereislova, A.18
Dong, R.P.19
Baselga, J.20
more..
-
11
-
-
1542503746
-
Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 1
-
Giaccone G, Herbst RS, Manegold C, Scagliotti G, Rosell R, Miller V, Natale RB, Schiller JH, Von Pawel J, Pluzanska A, Gatzemeier U, Grous J, Ochs JS, Averbuch SD, Wolf MK, Rennie P, Fandi A, Johnson DH: Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial - INTACT 1. J Clin Oncol 22: 777-784, 2004
-
(2004)
J Clin Oncol
, vol.22
, pp. 777-784
-
-
Giaccone, G.1
Herbst, R.S.2
Manegold, C.3
Scagliotti, G.4
Rosell, R.5
Miller, V.6
Natale, R.B.7
Schiller, J.H.8
Von Pawel, J.9
Pluzanska, A.10
Gatzemeier, U.11
Grous, J.12
Ochs, J.S.13
Averbuch, S.D.14
Wolf, M.K.15
Rennie, P.16
Fandi, A.17
Johnson, D.H.18
-
12
-
-
0026028343
-
Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers
-
Gullick WJ: Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers. Br Med Bull 47: 87-98, 1991
-
(1991)
Br Med Bull
, vol.47
, pp. 87-98
-
-
Gullick, W.J.1
-
13
-
-
0036848833
-
Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa)
-
Heimberger AB, Learn CA, Archer GE, McLendon RE, Chewning TA, Tuck FL, Pracyk JB, Friedman AH, Friedman HS, Bigner DD, Sampson JH: Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa). Clin Cancer Res 8: 3496-3502, 2002
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3496-3502
-
-
Heimberger, A.B.1
Learn, C.A.2
Archer, G.E.3
McLendon, R.E.4
Chewning, T.A.5
Tuck, F.L.6
Pracyk, J.B.7
Friedman, A.H.8
Friedman, H.S.9
Bigner, D.D.10
Sampson, J.H.11
-
14
-
-
1542713370
-
Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 2
-
Herbst RS, Giaccone G, Schiller JH, Natale RB, Miller V, Manegold C, Scagliotti G, Rosell R, Oliff I, Reeves JA, Wolf MK, Krebs AD, Averbuch SD, Ochs JS, Grous J, Fandi A, Johnson DH: Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial - INTACT 2. J Clin Oncol 22: 785-794, 2004
-
(2004)
J Clin Oncol
, vol.22
, pp. 785-794
-
-
Herbst, R.S.1
Giaccone, G.2
Schiller, J.H.3
Natale, R.B.4
Miller, V.5
Manegold, C.6
Scagliotti, G.7
Rosell, R.8
Oliff, I.9
Reeves, J.A.10
Wolf, M.K.11
Krebs, A.D.12
Averbuch, S.D.13
Ochs, J.S.14
Grous, J.15
Fandi, A.16
Johnson, D.H.17
-
15
-
-
0037431759
-
Severe acute interstitial pneumonia and gefitinib
-
Inoue A, Saijo Y, Maemondo M, Gomi K, Tokue Y, Kimura Y, Ebina M, Kikuchi T, Moriya T, Nukiwa T: Severe acute interstitial pneumonia and gefitinib. Lancet 361: 137-139, 2003
-
(2003)
Lancet
, vol.361
, pp. 137-139
-
-
Inoue, A.1
Saijo, Y.2
Maemondo, M.3
Gomi, K.4
Tokue, Y.5
Kimura, Y.6
Ebina, M.7
Kikuchi, T.8
Moriya, T.9
Nukiwa, T.10
-
16
-
-
0142055937
-
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
-
Kris MG, Natale RB, Herbst RS, Lynch TJ Jr, Prager D, Belani CP, Schiller JH, Kelly K, Spiridonidis H, Sandler A, Albain KS, Cella D, Wolf MK, Averbuch SD, Ochs JJ, Kay AC: Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 290: 2149-2158, 2003
-
(2003)
JAMA
, vol.290
, pp. 2149-2158
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
Lynch Jr., T.J.4
Prager, D.5
Belani, C.P.6
Schiller, J.H.7
Kelly, K.8
Spiridonidis, H.9
Sandler, A.10
Albain, K.S.11
Cella, D.12
Wolf, M.K.13
Averbuch, S.D.14
Ochs, J.J.15
Kay, A.C.16
-
17
-
-
18844417090
-
High incidence of disease recurrence in the brain and leptomeninges in patients with nonsmall cell lung carcinoma after response to gefitinib
-
Omuro AM, Kris MG, Miller VA, Franceschi E, Shah N, Milton DT, Abrey LE: High incidence of disease recurrence in the brain and leptomeninges in patients with nonsmall cell lung carcinoma after response to gefitinib. Cancer 103: 2344-2348, 2005
-
(2005)
Cancer
, vol.103
, pp. 2344-2348
-
-
Omuro, A.M.1
Kris, M.G.2
Miller, V.A.3
Franceschi, E.4
Shah, N.5
Milton, D.T.6
Abrey, L.E.7
-
18
-
-
1842500007
-
Phase II trial of gefitinib in recurrent glioblastoma
-
Rich JN, Reardon DA, Peery T, Dowell JM, Quinn JA, Penne KL, Wikstrand CJ, Van Duyn LB, Dancey JE, McLendon RE, Kao JC, Stenzel TT, Ahmed Rasheed BK, Tourt-Uhlig SE, Herndon JE 2nd, Vredenburgh JJ, Sampson JH, Friedman AH, Bigner DD, Friedman HS: Phase II trial of gefitinib in recurrent glioblastoma. J Clin Oncol 22: 133-142, 2004
-
(2004)
J Clin Oncol
, vol.22
, pp. 133-142
-
-
Rich, J.N.1
Reardon, D.A.2
Peery, T.3
Dowell, J.M.4
Quinn, J.A.5
Penne, K.L.6
Wikstrand, C.J.7
Van Duyn, L.B.8
Dancey, J.E.9
McLendon, R.E.10
Kao, J.C.11
Stenzel, T.T.12
Ahmed Rasheed, B.K.13
Tourt-Uhlig, S.E.14
Herndon II, J.E.15
Vredenburgh, J.J.16
Sampson, J.H.17
Friedman, A.H.18
Bigner, D.D.19
Friedman, H.S.20
more..
-
19
-
-
14944378048
-
Gefitinib ('Iressa', ZD1839) is active against brain metastases in a 77 year old patient
-
Roggero E, Busi G, Palumbo A, Pedrazzini A: Gefitinib ('Iressa', ZD1839) is active against brain metastases in a 77 year old patient. J Neurooncol 71: 277-280, 2005
-
(2005)
J Neurooncol
, vol.71
, pp. 277-280
-
-
Roggero, E.1
Busi, G.2
Palumbo, A.3
Pedrazzini, A.4
-
20
-
-
0028955388
-
Epidermal growth factor-related peptides and their receptors in human malignancies
-
Salomon DS, Brandt R, Ciardiello F, Normanno N: Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 19: 183-232, 1995
-
(1995)
Crit Rev Oncol Hematol
, vol.19
, pp. 183-232
-
-
Salomon, D.S.1
Brandt, R.2
Ciardiello, F.3
Normanno, N.4
-
21
-
-
0036896089
-
Gamma knife radiosurgery and brain metastases: Local control, survival, and quality of life
-
Vesagas TS, Aguilar JA, Mercado ER, Mariano MM: Gamma knife radiosurgery and brain metastases: local control, survival, and quality of life. J Neurosurg 97(5 Suppl): 507-510, 2002
-
(2002)
J Neurosurg
, vol.97
, Issue.5 SUPPL.
, pp. 507-510
-
-
Vesagas, T.S.1
Aguilar, J.A.2
Mercado, E.R.3
Mariano, M.M.4
-
22
-
-
0037819319
-
A case study documenting the anticancer activity of ZD1839 (Iressa) in the brain
-
Villano JL, Mauer AM, Vokes EE: A case study documenting the anticancer activity of ZD1839 (Iressa) in the brain. Ann Oncol 14: 656-658, 2003
-
(2003)
Ann Oncol
, vol.14
, pp. 656-658
-
-
Villano, J.L.1
Mauer, A.M.2
Vokes, E.E.3
-
23
-
-
0030061424
-
Specific inhibition of epidermal growth factor receptor tyrosine kinase by 4-anilinoquinazolines
-
Wakeling AE, Barker AJ, Davies DH, Brown DS, Green LR, Cartlidge SA, Woodburn JR: Specific inhibition of epidermal growth factor receptor tyrosine kinase by 4-anilinoquinazolines. Breast Cancer Res Treat 38: 67-73, 1996
-
(1996)
Breast Cancer Res Treat
, vol.38
, pp. 67-73
-
-
Wakeling, A.E.1
Barker, A.J.2
Davies, D.H.3
Brown, D.S.4
Green, L.R.5
Cartlidge, S.A.6
Woodburn, J.R.7
-
24
-
-
0346991841
-
EGFR tyrosine kinase inhibitor "gefitinib (Iressa)" for cancer therapy
-
Yano S, Yamaguchi M, Dong RP: EGFR tyrosine kinase inhibitor "gefitinib (Iressa)" for cancer therapy. Nippon Yakurigaku Zasshi 122: 491-497, 2003
-
(2003)
Nippon Yakurigaku Zasshi
, vol.122
, pp. 491-497
-
-
Yano, S.1
Yamaguchi, M.2
Dong, R.P.3
|