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Volumn 18, Issue 6, 2006, Pages 559-565

A meta-regression analysis of treatment effect modifiers in trials with flexible-dose oral sildenafil for erectile dysfunction in broad-spectrum populations

Author keywords

Meta analysis; Phosphodiesterase inhibitors; Randomized controlled trials; Sildenafil

Indexed keywords

SILDENAFIL;

EID: 33750493582     PISSN: 09559930     EISSN: 14765489     Source Type: Journal    
DOI: 10.1038/sj.ijir.3901479     Document Type: Review
Times cited : (10)

References (47)
  • 1
    • 2542438558 scopus 로고    scopus 로고
    • The multinational Men's Attitudes to Life Events and Sexuality (MALES) study: I. Prevalence of erectile dysfunction and related health concerns in the general population
    • Rosen RC, Fisher WA, Eardley I, Niederberger C, Nadel A, Sand M. The multinational Men's Attitudes to Life Events and Sexuality (MALES) study: I. Prevalence of erectile dysfunction and related health concerns in the general population. Curr Med Res Opin 2004; 20: 607-617.
    • (2004) Curr Med Res Opin , vol.20 , pp. 607-617
    • Rosen, R.C.1    Fisher, W.A.2    Eardley, I.3    Niederberger, C.4    Nadel, A.5    Sand, M.6
  • 2
    • 0042324048 scopus 로고    scopus 로고
    • Prevalence of erectile dysfunction and associated factors among men without concomitant diseases: A population study
    • Erectile Dysfunction Epidemiology Cross National Study Group
    • Nicolosi A, Glasser DB, Moreira ED, Villa M, Erectile Dysfunction Epidemiology Cross National Study Group. Prevalence of erectile dysfunction and associated factors among men without concomitant diseases: a population study. Int J Impot Res 2003; 15: 253-257.
    • (2003) Int J Impot Res , vol.15 , pp. 253-257
    • Nicolosi, A.1    Glasser, D.B.2    Moreira, E.D.3    Villa, M.4
  • 4
    • 0036871575 scopus 로고    scopus 로고
    • Oral agents: First-line therapy for erectile dysfunction
    • Brock G. Oral agents: first-line therapy for erectile dysfunction. Eur Urol Suppl 2002; 1: 12-18.
    • (2002) Eur Urol Suppl , vol.1 , pp. 12-18
    • Brock, G.1
  • 5
    • 0037195229 scopus 로고    scopus 로고
    • Erectile dysfunction: Comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil - Review of the literature
    • Gresser U, Gleiter CH. Erectile dysfunction: comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil - review of the literature. Eur J Med Res 2002; 7: 435-446.
    • (2002) Eur J Med Res , vol.7 , pp. 435-446
    • Gresser, U.1    Gleiter, C.H.2
  • 7
    • 1542756561 scopus 로고    scopus 로고
    • Vardenafil: A new approach to the treatment of erectile dysfunction
    • Hellstrom WJ. Vardenafil: a new approach to the treatment of erectile dysfunction. Curr Urol Rep 2003; 4: 479-487.
    • (2003) Curr Urol Rep , vol.4 , pp. 479-487
    • Hellstrom, W.J.1
  • 8
    • 0036755020 scopus 로고    scopus 로고
    • The efficacy of sildenafil citrate (viagra) in clinical populations: An update
    • Carson CC, Burnett AL, Levine LA, Nehra A. The efficacy of sildenafil citrate (viagra) in clinical populations: an update. Urology 2002; 60(Suppl 2B): 12-27.
    • (2002) Urology , vol.60 , Issue.SUPPL. 2B , pp. 12-27
    • Carson, C.C.1    Burnett, A.L.2    Levine, L.A.3    Nehra, A.4
  • 9
    • 33646539152 scopus 로고    scopus 로고
    • Efficacy of PDE-5-inhibitors for erectile dysfunction. A comparative meta-analysis of fixeddose regimen randomized controlled trials administering the International Index of Erectile Function in broad spectrum populations
    • in print
    • Berner MM, Kriston L, Harms A. Efficacy of PDE-5-inhibitors for erectile dysfunction. A comparative meta-analysis of fixeddose regimen randomized controlled trials administering the International Index of Erectile Function in broad spectrum populations. Int J Impot Res 2006 (in print).
    • (2006) Int J Impot Res
    • Berner, M.M.1    Kriston, L.2    Harms, A.3
  • 10
    • 0035213667 scopus 로고    scopus 로고
    • Systematic review of randomised controlled trials of sildenafil (Viagra) in the treatment of male erectile dysfunction
    • Burls A, Gold L, Clark W. Systematic review of randomised controlled trials of sildenafil (Viagra) in the treatment of male erectile dysfunction. Br J Gen Pract 2001; 51: 1004-1012.
    • (2001) Br J Gen Pract , vol.51 , pp. 1004-1012
    • Burls, A.1    Gold, L.2    Clark, W.3
  • 11
    • 0037166642 scopus 로고    scopus 로고
    • Sildenafil for male erectile dysfunction: A systematic review and meta-analysis
    • Fink HA, Mac Donald R, Rutks IR, Nelson DB, Wilt TJ. Sildenafil for male erectile dysfunction: a systematic review and meta-analysis. Arch Intern Med 2002; 162: 1349-1360.
    • (2002) Arch Intern Med , vol.162 , pp. 1349-1360
    • Fink, H.A.1    Mac Donald, R.2    Rutks, I.R.3    Nelson, D.B.4    Wilt, T.J.5
  • 12
    • 10844279076 scopus 로고    scopus 로고
    • Vardenafil (Levitra) for erectile dysfunction: A systematic review and meta-analysis of clinical trial reports
    • Markou S, Perimenis P, Gyftopoulos K, Athanasopoulos A, Barbalias G. Vardenafil (Levitra) for erectile dysfunction: a systematic review and meta-analysis of clinical trial reports. Int J Impot Res 2004; 16: 470-478.
    • (2004) Int J Impot Res , vol.16 , pp. 470-478
    • Markou, S.1    Perimenis, P.2    Gyftopoulos, K.3    Athanasopoulos, A.4    Barbalias, G.5
  • 13
    • 28544444480 scopus 로고    scopus 로고
    • An open-label, multicentre, randomized, crossover study comparing sildenafil citrate and tadalafil for treating erectile dysfunction in men naive to phosphodiesterase 5 inhibitor therapy
    • Eardley I, Mirone V, Montorsi F, Ralph D, Kell P, Warner MR et al. An open-label, multicentre, randomized, crossover study comparing sildenafil citrate and tadalafil for treating erectile dysfunction in men naive to phosphodiesterase 5 inhibitor therapy. BJU Int 2005; 96: 1323-1332.
    • (2005) BJU Int , vol.96 , pp. 1323-1332
    • Eardley, I.1    Mirone, V.2    Montorsi, F.3    Ralph, D.4    Kell, P.5    Warner, M.R.6
  • 14
    • 0030926566 scopus 로고    scopus 로고
    • The International Index of Erectile Function (IIEF): A multidimensional scale for assessment of erectile dysfunction
    • Rosen RC, Riley A, Wagner G. The International Index of Erectile Function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997; 49: 822-830.
    • (1997) Urology , vol.49 , pp. 822-830
    • Rosen, R.C.1    Riley, A.2    Wagner, G.3
  • 15
    • 0032792320 scopus 로고    scopus 로고
    • Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function
    • Cappelleri JC, Rosen RC, Smith MD, Mishra A, Osterloh IH. Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function. Urology 1999; 54: 346-351.
    • (1999) Urology , vol.54 , pp. 346-351
    • Cappelleri, J.C.1    Rosen, R.C.2    Smith, M.D.3    Mishra, A.4    Osterloh, I.H.5
  • 18
    • 0029785769 scopus 로고    scopus 로고
    • The relation between treatment benefit and underlying risk in meta-analysis
    • Sharp SJ, Thompson SG, Altman DG. The relation between treatment benefit and underlying risk in meta-analysis. BMJ 1996; 313: 735-738.
    • (1996) BMJ , vol.313 , pp. 735-738
    • Sharp, S.J.1    Thompson, S.G.2    Altman, D.G.3
  • 19
    • 0035859525 scopus 로고    scopus 로고
    • Systematic reviews in health care: Investigating and dealing with publication and other biases in meta-analysis
    • Sterne JAC, Egger M, Smith GD. Systematic reviews in health care: investigating and dealing with publication and other biases in meta-analysis. BMJ 2001; 323: 101-105.
    • (2001) BMJ , vol.323 , pp. 101-105
    • Sterne, J.A.C.1    Egger, M.2    Smith, G.D.3
  • 21
    • 0033619529 scopus 로고    scopus 로고
    • Explaining heterogeneity in metaanalysis: A comparison of methods
    • Thompson SG, Sharp SJ. Explaining heterogeneity in metaanalysis: a comparison of methods. Stat Med 1999; 18: 2693-2708.
    • (1999) Stat Med , vol.18 , pp. 2693-2708
    • Thompson, S.G.1    Sharp, S.J.2
  • 23
    • 0036686213 scopus 로고    scopus 로고
    • Sildenafil citrate (Viagra) in the treatment of men with erectile dysfunction in southern Latin America: A double-blind, randomized, placebo-controlled, parallel-group, multicenter, flexible-dose escalation study
    • Southern Latin America Sildenafil Study Group
    • Becher E, Tejada NA, Gomez R, Decia R, Southern Latin America Sildenafil Study Group. Sildenafil citrate (Viagra) in the treatment of men with erectile dysfunction in southern Latin America: a double-blind, randomized, placebo-controlled, parallel-group, multicenter, flexible-dose escalation study. Int J Impot Res 2002; 14(Suppl 2): 33-41.
    • (2002) Int J Impot Res , vol.14 , Issue.SUPPL. 2 , pp. 33-41
    • Becher, E.1    Tejada, N.A.2    Gomez, R.3    Decia, R.4
  • 24
    • 0033835542 scopus 로고    scopus 로고
    • Relationship between patient self-assessment of erectile function and the erectile function domain of the international index of erectile function
    • Cappelleri JC, Siegel RL, Osterloh IH, Rosen RC. Relationship between patient self-assessment of erectile function and the erectile function domain of the international index of erectile function. Urology 2000; 56: 477-481.
    • (2000) Urology , vol.56 , pp. 477-481
    • Cappelleri, J.C.1    Siegel, R.L.2    Osterloh, I.H.3    Rosen, R.C.4
  • 25
    • 0034864622 scopus 로고    scopus 로고
    • ASSESS-3: A randomised, double-blind, flexible-dose clinical trial of the efficacy and safety of oral sildenafil in the treatment of men with erectile dysfunction in Taiwan
    • Chen KK, Hsieh JT, Huang ST, Jiaan DB, Lin JS, Wang CJ et al. ASSESS-3: a randomised, double-blind, flexible-dose clinical trial of the efficacy and safety of oral sildenafil in the treatment of men with erectile dysfunction in Taiwan. Int J Impot Res 2001; 13: 221-229.
    • (2001) Int J Impot Res , vol.13 , pp. 221-229
    • Chen, K.K.1    Hsieh, J.T.2    Huang, S.T.3    Jiaan, D.B.4    Lin, J.S.5    Wang, C.J.6
  • 26
    • 0037562892 scopus 로고    scopus 로고
    • A double-blind, randomised- Placebo, controlled, parallel group, multicentre, flexible-dose escalation study to assess the efficacy and safety of sildenafil administered as required to male outpatients with erectile dysfunction in Korea
    • Choi HK, Ahn TY, Kim JJ, Kim SC, Paick JS, Suh JK et al. A double-blind, randomised- placebo, controlled, parallel group, multicentre, flexible-dose escalation study to assess the efficacy and safety of sildenafil administered as required to male outpatients with erectile dysfunction in Korea. Int J Impot Res 2003; 15: 80-86.
    • (2003) Int J Impot Res , vol.15 , pp. 80-86
    • Choi, H.K.1    Ahn, T.Y.2    Kim, J.J.3    Kim, S.C.4    Paick, J.S.5    Suh, J.K.6
  • 27
    • 0033119145 scopus 로고    scopus 로고
    • Sildenafil citrate (Viagra) in erectile dysfunction: Near normalization in men with broad-spectrum erectile dysfunction compared with age-matched healthy control subjects
    • Dinsmore WW, Hodges M, Hargreaves C, Osterloh IH, Smith MD, Rosen RC. Sildenafil citrate (Viagra) in erectile dysfunction: near normalization in men with broad-spectrum erectile dysfunction compared with age-matched healthy control subjects. Urology 1999; 53: 800-805.
    • (1999) Urology , vol.53 , pp. 800-805
    • Dinsmore, W.W.1    Hodges, M.2    Hargreaves, C.3    Osterloh, I.H.4    Smith, M.D.5    Rosen, R.C.6
  • 28
    • 18544381742 scopus 로고    scopus 로고
    • Efficacy and safety of flexible-dose oral sildenafil citrate (Viagra) in the treatment of erectile dysfunction in Brazilian and Mexican men
    • Glina S, Bertero E, Claro J, Damiao R, Faria G, Fregonesi A et al. Efficacy and safety of flexible-dose oral sildenafil citrate (Viagra) in the treatment of erectile dysfunction in Brazilian and Mexican men. Int J Impot Res 2002; 14(Suppl 2): S27-S32.
    • (2002) Int J Impot Res , vol.14 , Issue.SUPPL. 2
    • Glina, S.1    Bertero, E.2    Claro, J.3    Damiao, R.4    Faria, G.5    Fregonesi, A.6
  • 30
    • 0036687547 scopus 로고    scopus 로고
    • Efficacy and safety of oral sildenafil citrate (Viagra) in the treatment of male erectile dysfunction in Colombia, Ecuador, and Venezuela: A double-blind, multicenter, placebo-controlled study
    • Gomez F, Davila H, Costa A, Acuna A, Wadskier LA, Plua P et al. Efficacy and safety of oral sildenafil citrate (Viagra) in the treatment of male erectile dysfunction in Colombia, Ecuador, and Venezuela: a double-blind, multicenter, placebo-controlled study. Int J Impot Res 2002; 14(Suppl 2): S42-S47.
    • (2002) Int J Impot Res , vol.14 , Issue.SUPPL. 2
    • Gomez, F.1    Davila, H.2    Costa, A.3    Acuna, A.4    Wadskier, L.A.5    Plua, P.6
  • 31
    • 0038123144 scopus 로고    scopus 로고
    • The efficacy and safety of oral sildenafil in Thai men with erectile dysfunction: A randomized, double-blind, placebo controlled, flexible-dose study
    • for the Thai investigators in ASSESS-2 Study Group
    • Kongkanand A, Ratana-Olarn K, Ruangdilokrat S, Tantiwong A, for the Thai investigators in ASSESS-2 Study Group. The efficacy and safety of oral sildenafil in Thai men with erectile dysfunction: a randomized, double-blind, placebo controlled, flexible-dose study. J Med Assoc Thai 2003; 86: 195-205.
    • (2003) J Med Assoc Thai , vol.86 , pp. 195-205
    • Kongkanand, A.1    Ratana-Olarn, K.2    Ruangdilokrat, S.3    Tantiwong, A.4
  • 32
    • 0038600633 scopus 로고    scopus 로고
    • Efficacy and safety of sildenafil citrate (Viagra) for the treatment of erectile dysfunction in men in Egypt and South Africa
    • Levinson IP, Khalaf IM, Shaeer KZ, Smart DO. Efficacy and safety of sildenafil citrate (Viagra) for the treatment of erectile dysfunction in men in Egypt and South Africa. Int J Impot Res 2003; 15(Suppl 1): S25-S29.
    • (2003) Int J Impot Res , vol.15 , Issue.SUPPL. 1
    • Levinson, I.P.1    Khalaf, I.M.2    Shaeer, K.Z.3    Smart, D.O.4
  • 33
    • 0035156333 scopus 로고    scopus 로고
    • A dose-escalation study to assess the efficacy and safety of sildenafil citrate in men with erectile dysfunction
    • Meuleman E, Cuzin B, Opsomer RJ, Hartmann U, Bailey MJ, Maytom MC et al. A dose-escalation study to assess the efficacy and safety of sildenafil citrate in men with erectile dysfunction. BJU Int 2001; 87: 75-81.
    • (2001) BJU Int , vol.87 , pp. 75-81
    • Meuleman, E.1    Cuzin, B.2    Opsomer, R.J.3    Hartmann, U.4    Bailey, M.J.5    Maytom, M.C.6
  • 34
    • 0033833755 scopus 로고    scopus 로고
    • Asian sildenafil efficacy and safety study (ASSESS-1): A double-blind, placebo-controlled, flexible-dose study of oral sildenafil in Malaysian, Singaporean, and Filipino men with erectile dysfunction
    • Tan HM, Moh CL, Mendoza JB, Gana T, Albano GJ, de la CR et al. Asian sildenafil efficacy and safety study (ASSESS-1): a double-blind, placebo-controlled, flexible-dose study of oral sildenafil in Malaysian, Singaporean, and Filipino men with erectile dysfunction. Urology 2000; 56: 635-640.
    • (2000) Urology , vol.56 , pp. 635-640
    • Tan, H.M.1    Moh, C.L.2    Mendoza, J.B.3    Gana, T.4    Albano, G.J.5    De La, C.R.6
  • 35
    • 0036754975 scopus 로고    scopus 로고
    • Efficacy and safety of sildenafil citrate (Viagra) in black and Hispanic American men
    • Young JM, Bennett C, Gilhooly P, Wessells H, Ramos DE. Efficacy and safety of sildenafil citrate (Viagra) in black and Hispanic American men. Urology 2002; 60(Suppl 2B): 39-48.
    • (2002) Urology , vol.60 , Issue.SUPPL. 2B , pp. 39-48
    • Young, J.M.1    Bennett, C.2    Gilhooly, P.3    Wessells, H.4    Ramos, D.E.5
  • 36
    • 2942695870 scopus 로고    scopus 로고
    • Controlling the risk of spurious findings from meta-regression
    • Higgins JPT, Thompson SG. Controlling the risk of spurious findings from meta-regression. Stat Med 2004; 23: 1663-1682.
    • (2004) Stat Med , vol.23 , pp. 1663-1682
    • Higgins, J.P.T.1    Thompson, S.G.2
  • 37
    • 0037083255 scopus 로고    scopus 로고
    • Individual patient- Versus group-level data meta-regressions for the investigation of treatment effect modifiers: Ecological bias rears its ugly head
    • Anti-Lymphocyte Antibody Induction Therapy Study Group
    • Berlin JA, Santanna J, Schmid CH, Szczech LA, Feldman HI, Anti-Lymphocyte Antibody Induction Therapy Study Group. Individual patient- versus group-level data meta-regressions for the investigation of treatment effect modifiers: ecological bias rears its ugly head. Stat Med 2002; 21: 371-387.
    • (2002) Stat Med , vol.21 , pp. 371-387
    • Berlin, J.A.1    Santanna, J.2    Schmid, C.H.3    Szczech, L.A.4    Feldman, H.I.5
  • 38
    • 4444333174 scopus 로고    scopus 로고
    • Meta-regression detected associations between heterogeneous treatment effects and study-level, but not patient-level, factors
    • Schmid CH, Stark PC, Berlin JA, Landais P, Lau J. Meta-regression detected associations between heterogeneous treatment effects and study-level, but not patient-level, factors. J Clin Epidemiol 2004; 57: 683-697.
    • (2004) J Clin Epidemiol , vol.57 , pp. 683-697
    • Schmid, C.H.1    Stark, P.C.2    Berlin, J.A.3    Landais, P.4    Lau, J.5
  • 39
    • 0034823867 scopus 로고    scopus 로고
    • Funnel plots for detecting bias in meta-analysis: Guidelines on choice of axis
    • Sterne JA, Egger M. Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol 2001; 54: 1046-1055.
    • (2001) J Clin Epidemiol , vol.54 , pp. 1046-1055
    • Sterne, J.A.1    Egger, M.2
  • 41
    • 0032860673 scopus 로고    scopus 로고
    • Clinical efficacy of sildenafil citrate based on etiology and response to prior treatment
    • Jarow JP, Burnett AL, Geringer AM. Clinical efficacy of sildenafil citrate based on etiology and response to prior treatment. J Urol 1999; 162: 722-725.
    • (1999) J Urol , vol.162 , pp. 722-725
    • Jarow, J.P.1    Burnett, A.L.2    Geringer, A.M.3
  • 42
    • 0033253974 scopus 로고    scopus 로고
    • Indications and early results of sildenafil (Viagra) in erectile dysfunction
    • Virag R. Indications and early results of sildenafil (Viagra) in erectile dysfunction. Urology 1999; 54: 1073-1077.
    • (1999) Urology , vol.54 , pp. 1073-1077
    • Virag, R.1
  • 43
    • 14144250622 scopus 로고    scopus 로고
    • Risk factors in predicting a poor response to sildenafil citrate in elderly men with erectile dysfunction
    • Park K, Ku JH, Kim SW, Paick JS. Risk factors in predicting a poor response to sildenafil citrate in elderly men with erectile dysfunction. BJU Int 2005; 95: 366-370.
    • (2005) BJU Int , vol.95 , pp. 366-370
    • Park, K.1    Ku, J.H.2    Kim, S.W.3    Paick, J.S.4
  • 44
    • 0033811958 scopus 로고    scopus 로고
    • Efficacy, safety and patient acceptance of sildenafil citrate as treatment for erectile dysfunction
    • McMahon CG, Samali R, Johnson H. Efficacy, safety and patient acceptance of sildenafil citrate as treatment for erectile dysfunction. J Urol 2000; 164: 1192-1196.
    • (2000) J Urol , vol.164 , pp. 1192-1196
    • McMahon, C.G.1    Samali, R.2    Johnson, H.3
  • 45
    • 0032585801 scopus 로고    scopus 로고
    • Efficacy of sildenafil citrate (Viagra) is not affected by aetiology of erectile dysfunction
    • Shabsigh R. Efficacy of sildenafil citrate (Viagra) is not affected by aetiology of erectile dysfunction. Int J Clin Pract Suppl 1999; 102: 19-20.
    • (1999) Int J Clin Pract Suppl , vol.102 , pp. 19-20
    • Shabsigh, R.1
  • 46
    • 0030923529 scopus 로고    scopus 로고
    • Publication bias: Evidence of delayed publication in a cohort study of clinical research projects
    • Stern JM, Simes RJ. Publication bias: evidence of delayed publication in a cohort study of clinical research projects. BMJ 1997; 315: 640-645.
    • (1997) BMJ , vol.315 , pp. 640-645
    • Stern, J.M.1    Simes, R.J.2
  • 47
    • 0032573850 scopus 로고    scopus 로고
    • Effect of the statistical significance of results on the time to completion and publication of randomized efficacy trials
    • Ioannidis JP. Effect of the statistical significance of results on the time to completion and publication of randomized efficacy trials. JAMA 1998; 279: 281-286.
    • (1998) JAMA , vol.279 , pp. 281-286
    • Ioannidis, J.P.1


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