Exploration of the Mitsunobu reaction with Tosyl- and Boc-hydrazones as nucleophilic agents

Journal of Organic Chemistry

Volumn 71, Issue 18, 2006, Pages 7113-7116

  Keith, John M ^a   Gomez, Leslie ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; COOLING; ELECTRON TRANSPORT PROPERTIES; REACTION KINETICS; SUBSTITUTION REACTIONS;

BOC-HYDRAZONES; ELECTRON WITHDRAWING SUBSTITUENTS; MITSUNOBU REACTION; NUCLEOPHILIC AGENTS;

KETONES;

HYDRAZONE DERIVATIVE;

ALKYLATION; ARTICLE; ELECTRON TRANSPORT; MITSUNOBU REACTION; REACTION ANALYSIS; REACTION TIME;

ALCOHOLS; CHEMISTRY, ORGANIC; HYDRAZONES;

EID: 33750475898     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo061185g     Document Type: Article

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20. 2).
21. 3.
22. Boc-hydrazones were prepared by heating a 1:1 mixture of hydrazide and aldehyde (typically 1 g) in ethanol with 10 drops glacial HOAc at 80 °C for 15 min and then allowing the solution to cool. The hydrazone product can then be isolated by vacuum filtration.
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