The limitation of IL-10-exposed dendritic cells in the treatment of experimental autoimmune myasthenia gravis and myasthenia gravis

Cellular Immunology

Volumn 241, Issue 2, 2006, Pages 95-101

  Xiao, Bao Guo ^a,b   Duan, Rui Sheng ^c   Zhu, Wen Hua ^a   Lu, Chuan Zhen ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c THE FIRST AFFILIATED HOSPITAL OF SHANDONG FIRST MEDICAL UNIVERSITY   (China)

Author keywords

Delivery route; Dendritic cells; Experimental autoimmune myasthenia gravis; IL 10

Indexed keywords

CHOLINERGIC RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 10;

ADOPTIVE IMMUNOTHERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; CELL ISOLATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; IMMUNIZATION; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE MIGRATION INHIBITION TEST; LYMPH NODE; MYASTHENIA GRAVIS; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN CELL; T LYMPHOCYTE;

ANIMALS; B-LYMPHOCYTES; CELL MOVEMENT; CELL PROLIFERATION; DENDRITIC CELLS; FEMALE; HUMANS; IMMUNOGLOBULIN G; IMMUNOTHERAPY; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SUBCUTANEOUS; INTERFERON TYPE II; INTERLEUKIN-10; LYMPH NODES; MYASTHENIA GRAVIS; MYASTHENIA GRAVIS, AUTOIMMUNE, EXPERIMENTAL; RATS; RATS, INBRED LEW; RECEPTORS, CHOLINERGIC; T-LYMPHOCYTES; TISSUE THERAPY;

EID: 33750442235     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2006.08.005     Document Type: Article

References (26)

1. Zhang G.X., Xiao B.G., Yu L.Y., van der Meide P.H., Link H., et al. Interleukin 10 aggravates experimental autoimmune myasthenia gravis through inducing Th2 and B cell responses to AChR. J. Neuroimmunol. 113 (2001) 10-18
2. Poussin M.A., Goluszko E., Hughes T.K., et al. Suppression of experimental autoimmune myasthenia gravis in IL-10 gene-disrupted mice is associated with reduced B cells and serum cytotoxicity on mouse cell line expressing AChR. J. Neuro. Immunol. 111 (2000) 152-160
3. Matusevicius D., Navikas V., Palasik W., et al. Tumor necrosis factor-α, lymphotoxin, interleukin (IL)-6, IL-10, IL-12 and perforin mRNA expression in mononuclear cells in response to acetylcholine receptor is augmented in myasthenia gravis. J. Neuroimmunol. 71 (1996) 191-198
4. Huang Y.M., Kivisakk P., Ozenci V., et al. Increased levels of circulating acetylcholine receptor (AChR)-reactive IL-10-secreting cells are characteristic for myasthenia gravis (MG). Clin. Exp. Immunol. 118 (1999) 304-308
5. Howard M., and O'Garra A. Biological properties of interleukin 10. Immunol. Today 13 (1992) 198-200
6. Takayama T., Morelli A.E., Onai N., et al. Mammalian and viral IL-10 enhance C-C chemokine receptor 5 but down-regulate C-C chemokine receptor 7 expression by myeloid dendritic cells: impact on chemotactic responses and in vivo homing ability. J. Immunol. 166 (2001) 7136-7143
7. Okada N., Mori N., Koretomo R., et al. Augmentation of the migratory ability of DC-based vaccine into regional lymph nodes by efficient CCR7 gene transduction. Gene Ther. 12 (2005) 129-139
8. Furuhashi T., Yamaguchi Y., Wang F.S., et al. Hepatic CCR7lowCD62LlowCD45RClow allograft dendritic cells migrate to the splenic red pulp in immunologically unresponsive rats. J. Surg. Res. 124 (2005) 29-37
9. -/- mice and spontaneous development of asthma-like disease. Proc. Natl. Acad. Sci. USA 102 (2005) 10598-10603
10. Zhu M., Wei M.F., Liu F., et al. Interleukin-10 modified dendritic cells induce allo-hyporesponsiveness and prolong small intestine allograft survival. World J. Gastroenterol. 9 (2003) 2509-2512
11. Jiang H., Hou L., Qiao H., et al. Administration of tolerogenic dendritic cells induced by interleukin-10 prolongs rat splenic allograft survival. Trans. Proc. 36 (2004) 3255-3259
12. Weir C.R., Nicolson K., and Backstrom B.T. Experimental autoimmune encephalomyelitis induction in naïve mice by dendritic cells presenting a self-peptide. Immunol. Cell Biol. 80 (2002) 14-20
13. Duan R.S., Adikari S.B., Huang Y.M., et al. Protective potential of experimental autoimmune myasthenia gravis in Lewis rats by IL-10-modified dendritic cells. Neurobiol. Dis. 16 (2004) 461-467
14. Lindstrom J., Einarson B., and Tzartos S. Production and assay of antibodies to acetylcholine receptors. Meth. Enzymol. 74 (1981) 432-460
15. Berman P.W., and Patrick J. Experimental myasthenia gravis. A murine system. J. Exp. Med. 152 (1980) 507-520
16. Zhang G.X., Navikas V., and Link H. Cytokines and the pathogenesis of myasthenia gravis. Muscle Nerve 20 (1997) 543-551
17. Wang B., Zhuang L., Fujisawa H., et al. Enhanced epidermal Langerhans cell migration in IL-10 knockout mice. J. Immunol. 162 (1999) 277-283
18. Verginis P., Li H.S., and Carayanniotis G. Tolerogenic semimature dendritic cells suppress experimental autoimmune thyroiditis by activation of thyroglobulin-specific CD4+CD25+ T cells. J. Immunol. 174 (2005) 7433-7439
19. Feili-Hariri M., Falkner D.H., Gambotto A., et al. Dendritic cells transduced to express interleukin-4 prevent diabetes in nonobese diabetic mice with advanced insulitis. Hum. Gene Ther. 14 (2003) 13-23
20. Kim S.H., Kim S., Evans C.H., et al. Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4. J. Immunol. 166 (2001) 3499-3505
21. Morita Y., Yang J., Gupta R., et al. Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis. J. Clin. Invest. 107 (2001) 1275-1284
22. Zhang Q.H., Link H., and Xiao B.G. Efficacy of peripheral tolerance induced by dendritic cells is dependent on route of delivery. J. Autoimmunity 23 (2004) 37-43
23. Demangel C., Bertolino P., and Britton W.J. Autocrine IL-10 impairs DC-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12. Eur. J. Immunol. 32 (2002) 994-1002
24. Wu Q., Wang Y., Wang J., et al. The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues. J. Exp. Med. 190 (1999) 629-638
25. Soesatyo M., Thepen T., Ghufron M., et al. A study on the migration of macrophages and DC towards the gut. Adv. Exp. Med. Biol. 329 (1993) 321-326
26. Xiao B.G., Huang Y.M., Yang J.S., et al. Bone marrow-derived dendritic cells from experimental allergic encephalomyelitis induce immune tolerance to EAE in Lewis rats. Clin. Exp. Immunol. 125 (2001) 300-309