Ibogaine affects brain energy metabolism

European Journal of Pharmacology

Volumn 552, Issue 1-3, 2006, Pages 11-14

  Paškulin, Roman ^a   Jamnik, Polona ^b   Živin, Marko ^b   Raspor, Peter ^b   Štrukelj, Borut ^b  

^a OMI Institute   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Addiction; Energy metabolism; Glycolysis; Ibogaine; Proteomics; Rat brain; Tricarboxylic acid cycle

Indexed keywords

BRAIN PROTEIN; FRUCTOSE BISPHOSPHATE ALDOLASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; IBOGAINE; MALATE DEHYDROGENASE; PYRUVATE KINASE; TRICARBOXYLIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; CELL FUNCTION; CELL STRUCTURE; CITRIC ACID CYCLE; CONTROLLED STUDY; DETOXIFICATION; DRUG EFFECT; DRUG TOLERANCE; ENERGY METABOLISM; ENZYME INDUCTION; GLYCOLYSIS; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; TWO DIMENSIONAL ELECTROPHORESIS;

ANIMALS; BRAIN; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENERGY METABOLISM; IBOGAINE; INJECTIONS, INTRAPERITONEAL; MALE; PROTEINS; RATS; RATS, WISTAR; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TABERNAEMONTANA;

EID: 33750437295     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.09.008     Document Type: Article

References (26)

1. Ali S.F., Newport G.D., Slikker Jr. W., Rothman R.B., and Baumann M.H. Neuroendocrine and neurochemical effects of acute ibogaine administration: a time course evaluation. Brain Res. 737 (1996) 215-220
2. Ali S.F., Thiriet N., and Zwiller J. Acute ibogaine injection induces expression of the immediate early genes, egr-1 and c-fos, in mouse brain. Brain Res. Mol. Brain Res. 74 (1999) 237-241
3. Alper K.R. Ibogaine: a review. Alkaloids, Chem. Biol. 56 (2001) 1-38
4. Alper K.R., Lotsof H.S., Frenken G.M., Luciano D.J., and Bastiaans J. Treatment of acute opioid withdrawal with ibogaine. Am. J. Addict. 8 (1999) 234-242
5. Baumann M.H., Pablo J.P., Ali S.F., Rothman R.B., and Mash D.C. Noribogaine (12-hydroxyibogamine): a biologically active metabolite of the antiaddictive drug ibogaine. Ann. N. Y. Acad. Sci. 914 (2000) 354-368
6. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
7. Cappendijk S.L., and Dzoljic M.R. Inhibitory effects of ibogaine on cocaine self-administration in rats. Eur. J. Pharmacol. 241 (1993) 261-265
8. De Rios M.D., Grob C.S., and Baker J.R. Hallucinogens and redemption. J. Psychoact. Drugs 34 (2002) 239-248
9. Glick S.D., and Maisonneuve I.M. Development of novel medications for drug addiction. The legacy of an African shrub. Ann. N. Y. Acad. Sci. 909 (2000) 88-103
10. Glick S.D., Maisonneuve I.M., Kitchen B.A., and Fleck M.W. Antagonism of alpha 3 beta 4 nicotinic receptors as a strategy to reduce opioid and stimulant self-administration. Eur. J. Pharmacol. 438 (2002) 99-105
11. Görg A. Two-dimensional electrophoresis. Nature 349 (1991) 545-546
12. He D.Y., McGough N.N., Ravindranathan A., Jeanblanc J., Logrip M.L., Phamluong K., Janak P.H., and Ron D. Glial cell line-derived neutrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumption. J. Neurosci. 25 (2005) 619-628
13. Hough L.B., Pearl S.M., and Glick S.D. Tissue distribution of ibogaine after intraperitoneal and subcutaneous administration. Life Sci. 58 (1996) PL119-PL122
14. Leal M.B., de Souza D.O., and Elisabetsky E. Long-lasting ibogaine protection against NMDA-induced convulsions in mice. Neurochem. Res. 25 (2000) 1083-1087
15. Leal M.B., Michelin K., Souza D.O., and Elisabetsky E. Ibogaine attenuation of morphine withdrawal in mice: role of glutamate N-methyl-d-aspartate receptors. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 27 (2003) 781-785
16. Levant B., and Pazdernik T.L. Differential effects of ibogaine on local cerebral glucose utilization in drug-naive and morphine-dependent rats. Brain Res. 1003 (2004) 159-167
17. Lubec G., Krapfenbauer K., and Fountoulakis M. Proteomics in brain research: potentials and limitations. Prog. Neurobiol. 69 (2003) 193-211
18. Naranjo C. The Healing Journey. New Approaches to Consciousness (1973), Pantheon Books, New York, NY
19. Onaivi E.S., Ali S.F., Chirwa S.S., Zwiller J., Thiriet N., Akinshola B.E., and Ishiguro H. Ibogaine signals addiction genes and methamphetamine alteration of long-term potentiation. Ann. N. Y. Acad. Sci. 965 (2002) 28-46
20. Popik P. Facilation of memory retrieval by the "anti-addictive" alkaloid, ibogaine. Life Sci. 59 (1996) PL379-PL385
21. Rezvani A.H., Overstreet D.H., and Lee Y.W. Attenuation of alcohol intake by ibogaine in three strains of alcohol-preferring rats. Pharmacol. Biochem. Behav. 52 (1995) 615-620
22. Schneider J.A., and Sigg E.B. Neuropharmacological studies on ibogaine, an indole alkaloid with central-stimulant properties. Ann. N. Y. Acad. Sci. 66 (1957) 765-776
23. Sharma S.K., Yashpal K., Fundytus M.E., Sauriol F., Henry J.L., and Coderre T.J. Alternations in brain metabolism by chronic morphine treatment: NMR studies in rat CNS. Neurochem. Res. 28 (2003) 1369-1373
24. Sherman A.D., and Mitchell C.L. Influence of naloxone and tolerance on citric acid cycle response to morphine and pain. Neuropharmacology 12 (1973) 363-366
25. Squire L.R. Fundamental Neuroscience. Second ed. (2002), Academic Press, Amsterdam
26. Yan J.X., Wait R., Berkelman T., Harry R.A., Westbrook J.A., Wheeler C.H., and Dunn M.J. A modified silver staining protocol for visualization of proteins compatible with matrix-assisted laser desorption/ionization and electrospray ionization-mass spectrometry. Electrophoresis 21 (2000) 3666-3672