Application of a new subretinal injection device in the dog

Cell Transplantation

Volumn 15, Issue 6, 2006, Pages 511-519

  Komáromy, András M ^a   Varner, Signe E ^b   De Juan, Eugene ^c   Acland, Gregory M ^d   Aguirre, Gustavo D ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b SurModics Inc   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Department of Obstetrics Gynecology   (United States)

Author keywords

Animal model; Dog; Retinitis pigmentosa; Subretinal injection

Indexed keywords

INDIAN INK; SODIUM CHLORIDE;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR EYE CHAMBER; ARTICLE; BIOMEDICAL TECHNOLOGY ASSESSMENT; CANNULA; CHOROID; CONJUNCTIVA; CONTROLLED STUDY; CONVENTIONAL SUBRETINAL INJECTION DEVICE; DEVICE; DOG; EVALUATION; EYE INFLAMMATION; FEMALE; GENE; HISTOLOGY; INJECTION SITE; MALE; MONITORING; MUTANT; NEEDLE; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROGRESSIVE ROD CONE DEGENERATION GENE; RPE65 GENE; SCLERA; SCLEROTOMY;

ANIMALS; CHOROID; DOGS; FEMALE; INJECTIONS; MALE; OPHTHALMOSCOPY; PIGMENT EPITHELIUM OF EYE; RETINA; RETINAL DEGENERATION;

ADENO-ASSOCIATED VIRUS; ANIMALIA; CANIS FAMILIARIS;

EID: 33750431877     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000006783981701     Document Type: Article

References (14)

1. Acland, G. M.; Aguirre, G. D.; Bennett, J.; Aleman, T. S.; Cideciyan, A. V.; Bennicelli, J.; Dejneka, N. S.; Pearce-Kelling, S. E.; Maguire, A. M.; Palczewski, K.; Hauswirth, W. W.; Jacobson, S. G. Long-term restoration of rod and cone vision by single dose rAAV-mdiated gene transfer to the retina in a canine model of childhood blindness. Mol. Ther. 12:1072-1082; 2005.
2. Acland, G. M.; Aguirre, G. D.; Ray, J.; Zhang, Q.; Aleman, T. S.; Cideciyan, A. V.; Pearce-Kelling, S. E.; Anand, V.; Zeng, Y.; Maguire, A. M.; Jacobson, S. G.; Hauswirth, W. W.; Bennett, J. Gene therapy restores vision in a canine model of childhood blindness. Nat. Genet. 28:92-95; 2001.
3. Aguirre, G. D.; Acland, G. M. Variation in retinal degeneration phenotype inherited at the prcd locus. Exp. Eye Res. 46:663-687; 1988.
4. Ali, R. R.; Sarra, G. M.; Stephens, C.; Alwis, M. D.; Bainbridge, J. W.; Munro, P. M.; Fauser, S.; Reichel, M. B.; Kinnon, C.; Hunt, D. M.; Bhattacharya, S. S.; Thrasher, A. J. Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy. Nat. Genet. 25:306-310; 2000.
5. Bennett, J.; Anand, V.; Acland, G. M.; Maguire, A. M. Cross-species comparison of in vivo reporter gene expression after recombinant adeno-associated virus-mediated retinal transduction. Methods Enzymol. 316:777-789; 2000.
6. Bennett, J.; Tanabe, T.; Sun, D.; Zeng, Y.; Kjeldbye, H.; Gouras, P.; Maguire, A. M. Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy. Nat. Med. 2:649-654; 1996.
7. Dudus, L.; Anand, V.; Acland, G. M.; Chen, S. J.; Wilson, J. M.; Fisher, K. J.; Maguire, A. M.; Bennett, J. Persistent transgene product in retina, optic nerve and brain after intraocular injection of rAAV. Vis. Res. 39:2545-2553; 1999.
8. Kumar-Singh, R.; Farber, D. B. Encapsidated adenovirus mini-chromosome-mediated delivery of genes to the retina: application to the rescue of photoreceptor degeneration. Hum. Mol. Genet. 7:1893-1900; 1998.
9. Schraermeyer, U.; Thumann, G.; Luther, T.; Kociok, N.; Armhold, S.; Kruttwig, K.; Andressen, C.; Addieks, K.; Bartz-Schmidt, K. U. Subretinally transplanted embryonic stem cells rescue photoreceptor cells from degeneration in the RCS rats. Cell Transplant. 10:673-680; 2001.
10. Smith, P. J.; Pennea, L.; MacKay, E. O.; Mames, R. N. Identification of sclerotomy sites for posterior segment surgery in the dog. Vet. Comp. Ophthalmol. 7:180-191; 1997.
11. Smith, A. J.; Schlichtenbrede, F. C.; Tschernutter, M.; Bainbridge, J. W.; Thrasher, A. J.; Ali, R. R. AAV-Mediated gene transfer slows photoreceptor loss in the RCS rat model of retinitis pigmentosa. Mol. Ther. 8:188-195; 2003.
12. Ueda, J.; Sawaguchi, S.; Hanyu, T.; Yaoeda, K.; Fukuchi, T.; Abe, H.; Ozawa, H. Experimental glaucoma model in the rat induced by laser trabecular photocoagulation after an intracameral injection of India ink. Jpn. J. Ophthalmol. 42:337-344; 1998.
13. Verdugo, M. E.; Alling, J.; Lazar, E. S.; del Cerro, M.; Ray, J.; Aguirre, G. Posterior segment approach for subretinal transplantation of injection in the canine model. Cell Transplant. 10:317-327; 2001.
14. Vollrath, D.; Feng, W.; Duncan, J. L.; Yasumura, D.; D'Cruz, P. M.; Chappelow, A.; Matthes, M. T.; Kay. M. A.; LaVail, M. M. Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk. Proc. Natl. Acad. Sci. USA 98:12584-12589; 2001.