Increased expression and function of the myocardial Na-K-2Cl cotransporter in failing rat hearts

Basic Research in Cardiology

Volumn 101, Issue 6, 2006, Pages 471-478

  Andersen, Geir Øystein ^a,e   Øie, Erik ^a,b,c   Vinge, Leif Erik ^a,b,c   Yndestad, Arne ^a   Attramadal, Håvard ^a,b,d   Skomedal, Tor ^a   Osnes, Jan Bjørn ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c DIAKONHJEMMET HOSPITAL   (Norway)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

^e ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

86Rb+ influx; Bumetanide; Cardiomyocytes; Congestive heart failure; Na K 2Cl cotransporter

Indexed keywords

BUMETANIDE; MESSENGER RNA; RUBIDIUM 86; SODIUM POTASSIUM CHLORIDE COTRANSPORTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOTHELIUM CELL; FIBROBLAST; HEART FAILURE; HEART INFARCTION; HEART MUSCLE CELL; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; RAT STRAIN; SMOOTH MUSCLE FIBER; STATISTICAL SIGNIFICANCE;

ANIMALS; BUMETANIDE; CARDIAC OUTPUT, LOW; GENE EXPRESSION REGULATION; MALE; MYOCARDIAL INFARCTION; MYOCARDIUM; MYOCYTES, CARDIAC; RATS; RATS, WISTAR; RNA, MESSENGER; RUBIDIUM RADIOISOTOPES; SODIUM POTASSIUM CHLORIDE SYMPORTER INHIBITORS; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS; VENTRICULAR REMODELING;

EID: 33750393150     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00395-006-0604-5     Document Type: Article

References (31)

1. + efflux in rat heart. Pharmacol Toxicol 79:169-176
2. + efflux in the rat heart. Res Com Mol Pathol Pharmacol 107:89-104
3. 1-Adrenergic activation of myocardial Na/K/ 2Cl-cotransport involving mitogen-activated protein kinase. Am J Physiol 275:H641-H648
4. 1-AR-mediated activation of NKCC in rat cardiomyocytes involves ERK-dependent phosphorylation of the cotransporter. Am J Physiol 286:H1354-H1360
5. ++ during ischaemia and reperfusion. Am J Physiol 270:C608-C618
6. i and underlies disturbed calcium handling in the rabbit pressure and volume overload heart failure model. Cardiovasc Res 57:1015
7. Bers DM, Pogwizd SM, Schlotthauer K (2002) Upregulated Na/Ca exchange is involved in both contractile dysfunction and arrhythmogenesis in heart failure. Basic Res Cardiol 97:I36-42
8. Clemo HF, Baumgarten CM (1991) Atrial natriuretic factor decreases cell volume of rabbit atrial and ventricular myocytes. Am J Physiol 260:C681-C690
9. +/2Cl - cotransport by cGMP and atrial natriuretic factor. J Gen Physiol 100:89-114
10. + concentration is elevated in heart failure but Na/K pump function Is unchanged. Circulation 105:2543-2548
11. +/Cl - co-transport in chick cardiac cells. Biochem Biophys Res Comm 134:326-331
12. Haas M (1994) The Na-K-Cl cotransporters. Am J Physiol 267:C869-C885
13. Haas M, Forbush B (2000) The Na-K-Cl cotransporter of secretory epithelia. Annu Rev Physiol 62:515-534
14. Jacobson SL, Piper HM (1986) Cell cultures of adult cardiomyocytes as models of the myocardium. J Mol Cell Cardiol 18:661-678
15. Jiang G, Akar F, Cobbs SL, Lomashvilli K, Lakkis R, Gordon FJ, Sutliff RL, O'Neill WC (2004) Blood pressure regulates the activity and function of the Na-K-2Cl cotransporter in vascular smooth muscle. Am J Physiol 286:H1552-H1557
16. + fluxes in myocytes by ouabain and recovery from metabolic inhibition. Am J Physiol 259:H962-H972
17. Lytle C, Xu J-C, Biemesderfer D, Forbush B (1995) Distribution and diversity of Na-K-Cl cotransport proteins: A study with monoclonal antibodies. Am J Physiol 269:C1496-C1505
18. Marumo R, Kaizuma S, Nogae S, Kanazawa M, Kimura T, Saito T, Ito S, Matsubara M (1998) Differential upregulation of rat Na-K-Cl cotransporter, rBSC1, mRNA in the thick ascending limb of Henle in different pathological conditions. Kidney Int 54:877-888
19. - cotransporter. Am J Physiol 283:H1846-H1855
20. + pump activation during short-term exposure of cardiac myocytes to aldosterone. Am J Physiol 274:C175-C181
21. e changes during ischemia in rat heart. Am J Physiol 263:H333-H340
22. Nogae S, Michimata M, Kanazawa M, Honda S, Ohta M, Imai Y, Ito S, Matsubara M (2000) Cardiac infarcts increase sodium transporter transcripts (rBSC1) in the thick ascending limb of Henle. Kidney Int 57:2055-2063
23. Øie E, Vinge LE, Tønnessen T, Grøgaard HK, Kjekshus H, Christensen G, Smiseth OA, Attramadal H (1997) Transient, isopeptide-specific induction of myocardial endothelin-1 mRNA in congestive heart failure in rats. Am J Physiol 273:H1727-H1736
24. Panet R, Markus M, Atlan H (1994) Bumetanide and furosemide inhibited vascular endothelial cell proliferation. J Cell Physiol 158:121-127
25. Peiro C, Angulo J, Llergo JL, Rodriguez-Manas L, Marin J, Sanchez-Ferrer CF (1997) Angiotensin II mediates cell hypertrophy in vascular smooth muscle cultures from hypertensive Ren-2 transgenic rats by an amiloride- and furosemide-sensitive mechanism. Biochem Biophys Res Commun 240:367-371
26. Ramasamy R, Liu H, Anderson S, Lundmark J, Schaefer S (1995) Ischemic preconditioning stimulates sodium and proton transport in isolated rat hearts. J Clin Invest 96:1464-1472
27. - cotransporter. Am J Physiol 281:H515-H522
28. - cotransport in cultured vascular smooth muscle cells: Stimulation by angiotensin II and calcium ionophores, inhibition by cyclic AMP and calmodulin antagonists. J Membr Biol 99:51-63
29. Staahltoft D, Nielsen S, Janjua NR, Christensen S, Skott O, Marcussen N, Jonassen TE (2002) Losartan treatment normalizes renal sodium and water handling in rats with mild congestive heart failure. Am J Physiol 282:F307-F315
30. Swynghedauw B (1999) Molecular mechanisms of myocardial remodelling. Physiol Rev 79:215
31. -l - cotransporter expression in rat skeletal muscle. Am J Physiol 277:R154-R161